ALKBH2 Activators
ALKBH2 Activators belong to a distinctive chemical class that targets the AlkB homolog 2 (ALKBH2) protein, a member of the AlkB family of dioxygenases. These small molecules exert their modulatory effects by specifically interacting with the ALKBH2 enzyme, which plays a pivotal role in the repair of DNA alkylation damage. ALKBH2 is instrumental in the demethylation of alkylated DNA bases, contributing to the preservation of genomic integrity and stability. The activators operate through a mechanism that enhances the catalytic activity of ALKBH2, thereby facilitating its involvement in the reversal of DNA lesions induced by alkylating agents. This targeted activation of ALKBH2 underscores the significance of this chemical class in the cellular response to genotoxic stress, where efficient repair mechanisms are crucial for maintaining the fidelity of the genetic material.
Structurally, ALKBH2 Activators exhibit a unique configuration that allows for selective binding to the ALKBH2 active site, fostering an environment conducive to increased enzymatic activity. The intricate interplay between these activators and the ALKBH2 protein underscores their potential as tools for unraveling the molecular intricacies of DNA repair processes. The exploration of ALKBH2 Activators holds promise not only for advancing our understanding of cellular mechanisms involved in DNA repair but also for unveiling novel strategies to modulate these processes for various applications, with implications for fields ranging from basic biological research to biotechnological developments.
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Items 1 to 10 of 12 total
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| Product Name | CAS # | Catalog # | QUANTITY | Price | Citations | RATING |
|---|---|---|---|---|---|---|
5-Azacytidine | 320-67-2 | sc-221003 | 500 mg | $280.00 | 4 | |
A cytidine analog that inhibits DNA methylation and reactivates methylation-silenced genes. Its action on the DNA methylation could indirectly enhance the DNA repair activity of ALKBH2. | ||||||
Fluorouracil | 51-21-8 | sc-29060 sc-29060A | 1 g 5 g | $36.00 $149.00 | 11 | |
An antimetabolite that integrates into RNA and DNA and inhibits thymidylate synthase. This can lead to DNA damage, potentially upregulating the repair function of ALKBH2. | ||||||
Cisplatin | 15663-27-1 | sc-200896 sc-200896A | 100 mg 500 mg | $76.00 $216.00 | 101 | |
A platinum-containing compound that forms intra- and inter-strand DNA cross-links, leading to DNA damage. This damage could indirectly prompt increased activity of ALKBH2. | ||||||
Etoposide (VP-16) | 33419-42-0 | sc-3512B sc-3512 sc-3512A | 10 mg 100 mg 500 mg | $32.00 $170.00 $385.00 | 63 | |
This topoisomerase II inhibitor stabilizes the enzyme-DNA cleavage complex, leading to DNA strand breaks. The subsequent DNA damage could require enhanced activity of ALKBH2. | ||||||
Camptothecin | 7689-03-4 | sc-200871 sc-200871A sc-200871B | 50 mg 250 mg 100 mg | $57.00 $182.00 $92.00 | 21 | |
A topoisomerase I inhibitor causing DNA strand breaks. This can lead to DNA damage, potentially increasing the requirement for ALKBH2 activity. | ||||||
Doxorubicin | 23214-92-8 | sc-280681 sc-280681A | 1 mg 5 mg | $173.00 $418.00 | 43 | |
An anthracycline antibiotic that intercalates into DNA and inhibits topoisomerase II, leading to DNA damage. This necessitates the repair function of ALKBH2. | ||||||
Methotrexate | 59-05-2 | sc-3507 sc-3507A | 100 mg 500 mg | $92.00 $209.00 | 33 | |
An antifolate that inhibits dihydrofolate reductase, leading to thymidine depletion and resultant DNA damage. This could indirectly increase the activity of ALKBH2. | ||||||
Bleomycin Sulfate | 9041-93-4 | sc-200134 sc-200134A sc-200134B sc-200134C | 10 mg 50 mg 100 mg 500 mg | $206.00 $612.00 $1020.00 $2856.00 | 38 | |
A glycopeptide antibiotic that causes DNA strand breaks, leading to DNA damage. The subsequent DNA damage could require enhanced activity of ALKBH2. | ||||||
Amsacrine hydrochloride | 54301-15-4 | sc-214540 | 10 mg | $232.00 | ||
An acridine derivative that intercalates into DNA and inhibits topoisomerase II, causing DNA strand breaks. This DNA damage could indirectly prompt increased activity of ALKBH2. | ||||||
Hydroxyurea | 127-07-1 | sc-29061 sc-29061A | 5 g 25 g | $76.00 $255.00 | 18 | |
A ribonucleotide reductase inhibitor causing DNA damage through replication stress. This could potentially increase the activity of ALKBH2. | ||||||