Date published: 2025-11-4

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Akt1 Inhibitors

Akt1 inhibitors belong to a specific chemical class of compounds that target and inhibit the activity of the serine/threonine kinase called Akt1, which is a critical component of the phosphatidylinositol 3-kinase (PI3K) signaling pathway. This pathway plays a crucial role in regulating various cellular processes, including cell growth, survival, proliferation, and metabolism. Akt1, also known as protein kinase B (PKB), is a central mediator in this pathway, and its dysregulation has been implicated in several diseases, particularly cancer. The Akt1 inhibitors are designed to selectively bind to the active site of Akt1 and disrupt its catalytic activity. By doing so, they can interfere with downstream signaling events that would typically promote cell survival and proliferation. These inhibitors act as allosteric modulators, preventing the transfer of phosphate groups to specific target proteins involved in the PI3K pathway. As a result, the inhibition of Akt1 signaling can lead to cell cycle arrest and apoptosis, inhibiting the growth and survival of cancer cells. The chemical structures of Akt1 inhibitors can vary significantly, but they typically possess specific functional groups that facilitate their interaction with the active site of Akt1. Some of these compounds are small molecules, while others may be peptidic or protein-based in nature. Researchers continue to explore and develop new Akt1 inhibitors with improved potency, selectivity, and pharmacokinetic properties, aiming to enhance their efficacy and minimize off-target effects. Due to their ability to specifically target a key signaling molecule involved in cancer and other diseases, Akt1 inhibitors have garnered significant attention in the field of drug development.

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Items 1 to 10 of 14 total

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Product NameCAS #Catalog #QUANTITYPriceCitationsRATING

H-89 dihydrochloride

130964-39-5sc-3537
sc-3537A
1 mg
10 mg
$92.00
$182.00
71
(2)

H-89 dihydrochloride (CAS 130964-39-5) is a chemical compound known for its role as an inhibitor of Akt1, a crucial serine/threonine kinase involved in cell signaling pathways. By blocking Akt1 activity, H-89 dihydrochloride modulates cellular processes, offering potential insights into various biological functions.

MK-2206 dihydrochloride

1032350-13-2sc-364537
sc-364537A
5 mg
10 mg
$178.00
$325.00
67
(1)

MK-2206 dihydrochloride (CAS 1032350-13-2) is a chemical compound known for its role as an Akt1 inhibitor. By targeting and inhibiting Akt1, it interferes with the function of this specific protein, potentially impacting cellular processes and signaling pathways.

Perifosine

157716-52-4sc-364571
sc-364571A
5 mg
10 mg
$184.00
$321.00
1
(2)

An Akt1 inhibitor that has been studied in multiple cancer types, including solid tumors and hematological malignancies.

KT 5720

108068-98-0sc-3538
sc-3538A
sc-3538B
50 µg
100 µg
500 µg
$97.00
$144.00
$648.00
47
(2)

KT 5720 (CAS 108068-98-0) is a chemical compound that functions as an inhibitor specifically targeting Akt1, a serine/threonine kinase. By obstructing Akt1 activity, it modulates cellular signaling pathways involved in various cellular processes.

Triciribine

35943-35-2sc-200661
sc-200661A
1 mg
5 mg
$102.00
$138.00
14
(1)

Triciribine (CAS 35943-35-2) is a potent inhibitor of Akt1, a crucial enzyme in cell signaling pathways. By blocking Akt1 activity, Triciribine interferes with certain cellular processes, influencing cell growth and survival regulation. Its role as an Akt1 inhibitor has garnered significant interest in the scientific community due to its potential impact on various cellular functions.

Akt Inhibitor VIII, Isozyme-Selective, Akti-1/2

612847-09-3sc-202048
sc-202048A
1 mg
5 mg
$204.00
$265.00
29
(1)

Akt Inhibitor VIII (CAS 612847-09-3), also known as Isozyme-Selective Akti-1/2, is a chemical compound that acts as an inhibitor specifically targeting Akt1. By selectively inhibiting Akt1, it modulates its activity, which plays a crucial role in various cellular processes.

(2S)-2-(4-Chlorophenyl)-1-[4-[(5R,7R)-6,7-dihydro-7-hydroxy-5-methyl-5H-cyclopentapyrimidin-4-yl]-1-piperazinyl]-3-[(1-methylethyl)amino]-1-propanone

sc-501166
5 mg
$540.00
(0)

A potent and selective Akt1 inhibitor that has demonstrated anti-tumor activity in breast cancer and other solid tumors.

ML-9

105637-50-1sc-200519
sc-200519A
sc-200519B
sc-200519C
10 mg
50 mg
100 mg
250 mg
$110.00
$440.00
$660.00
$1200.00
2
(1)

ML-9 (CAS 105637-50-1) is a chemical compound known for its inhibitory action on Akt1. It functions as an antagonist, modulating the activity of Akt1, a protein kinase involved in regulating various cellular processes. Its interaction with Akt1 can potentially impact cellular signaling pathways, offering insights into Akt1-dependent molecular mechanisms.

A-674563

552325-73-2sc-364393
sc-364393A
2 mg
5 mg
$232.00
$413.00
(1)

A-674563 (CAS 552325-73-2) is a chemical compound known for its role as an Akt1 inhibitor. It acts by selectively targeting and inhibiting Akt1, a protein kinase involved in various cellular processes. This inhibition may have significant implications in cellular research and understanding intracellular signaling pathways.

GSK 690693

937174-76-0sc-363280
sc-363280A
10 mg
50 mg
$255.00
$1071.00
4
(1)

GSK 690693 (CAS 937174-76-0) is a chemical compound known for its role as a potent inhibitor of Akt1, a serine/threonine protein kinase. By specifically targeting Akt1, it interferes with its normal cellular functions, potentially influencing various biological processes.