A-674563 (CAS 552325-73-2)
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A-674563 is a potent selective protein kinase B/Akt inhibitor (IC50 = 14 nM). A-674563 also shows inhibitory activity against PKA and CDK2 (IC50′s: PKA = 16 nM; CDK2 = 46 nM). A-674563 has been shown to have a significant effect on depolarization of purkinje fiber in an in vitro assay, and severe CV toxicity (e.g. hypotension) in vivo. The X-ray structure of A-674563 bound to protein kinase A, which exhibts 80% homology with Akt in the kinase domain, suggested the phenyl group is not tightly bound in the ligand-protein complex. The Akt inhibitor A-674563 displayed proliferation of tumor cells (EC50: 0.4 μM). When given in combination, A-674563 enhanced the efficacy of paclitaxel (Taxol, sc-201439) in a PC-3 xenograft model.
A-674563 (CAS 552325-73-2) References
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Ordering Information
| Product Name | Catalog # | UNIT | Price | Qty | FAVORITES | |
A-674563, 2 mg | sc-364393 | 2 mg | $232.00 | |||
A-674563, 5 mg | sc-364393A | 5 mg | $413.00 |