AKR7A4 Activators
AKR7A4 activators refers to a class of chemical compounds that play a crucial role in modulating the activity of the AKR7A4 enzyme. AKR7A4, or Aldo-Keto Reductase 7A4, is a member of the aldo-keto reductase superfamily of enzymes, which are primarily involved in the detoxification of endogenous and exogenous aldehydes and ketones. These enzymes contribute to cellular homeostasis by catalyzing the reduction of carbonyl compounds to their corresponding alcohols, thereby preventing the buildup of harmful reactive intermediates. AKR7A4, in particular, is primarily found in the liver, where it participates in the detoxification of a wide range of substrates, including toxic aldehydes generated during various metabolic processes.
AKR7A4 activators are chemical compounds that enhance the catalytic activity of the AKR7A4 enzyme, leading to an increased rate of reduction of its substrates. The activation of AKR7A4 can have important implications for the overall metabolic processes within an organism. By facilitating the detoxification of aldehydes and ketones, AKR7A4 activators may contribute to the maintenance of cellular redox balance and the prevention of oxidative stress. The precise mechanisms by which these activators interact with AKR7A4 are still an area of ongoing research, and the identification of specific compounds that can activate this enzyme may hold promise for potential applications in various fields.
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| Product Name | CAS # | Catalog # | QUANTITY | Price | Citations | RATING |
|---|---|---|---|---|---|---|
NADPH tetrasodium salt | 2646-71-1 | sc-202725 sc-202725A sc-202725B sc-202725C | 25 mg 50 mg 250 mg 1 g | $46.00 $82.00 $280.00 $754.00 | 11 | |
Nicotinamide adenine dinucleotide phosphate, a cofactor for AKR enzymes, directly activating its activity by providing the reducing equivalents necessary for catalysis. | ||||||
Ibuprofen | 15687-27-1 | sc-200534 sc-200534A | 1 g 5 g | $52.00 $86.00 | 6 | |
A non-steroidal anti-inflammatory drug (NSAID) that indirectly activates AKR7A4 by modulating inflammatory pathways, potentially leading to changes in enzyme expression and activity. | ||||||
Prednisone | 53-03-2 | sc-205816 sc-205816A sc-205816B | 1 g 5 g 25 g | $41.00 $133.00 $663.00 | 2 | |
A synthetic glucocorticoid that directly activates AKR7A4 by modulating glucocorticoid signaling pathways, which can affect the enzyme's expression and function. | ||||||
Aspirin | 50-78-2 | sc-202471 sc-202471A | 5 g 50 g | $20.00 $41.00 | 4 | |
Another NSAID that indirectly activates AKR7A4 by increasing inflammatory pathways. The resulting changes in inflammation may indirectly activate the enzyme's activity. | ||||||
Tamoxifen | 10540-29-1 | sc-208414 | 2.5 g | $256.00 | 18 | |
A selective estrogen receptor modulator (SERM) that indirectly activates AKR7A4 by modulating estrogen receptor signaling, which can affect the metabolism of estrogen-derived substrates. | ||||||
Dexamethasone | 50-02-2 | sc-29059 sc-29059B sc-29059A | 100 mg 1 g 5 g | $76.00 $82.00 $367.00 | 36 | |
A synthetic glucocorticoid that directly activates AKR7A4 by modulating glucocorticoid signaling pathways, which can lead to changes in the enzyme's expression and activity. | ||||||
Resveratrol | 501-36-0 | sc-200808 sc-200808A sc-200808B | 100 mg 500 mg 5 g | $60.00 $185.00 $365.00 | 64 | |
An antioxidant that indirectly activates AKR7A4 by modulating oxidative stress, potentially increasing the enzyme's activity by altering the cellular redox environment. | ||||||
Cisplatin | 15663-27-1 | sc-200896 sc-200896A | 100 mg 500 mg | $76.00 $216.00 | 101 | |
A chemotherapeutic agent that indirectly activates AKR7A4 by increasing drug metabolism pathways, which may alter the enzyme's involvement in detoxification processes. | ||||||
PGE2 | 363-24-6 | sc-201225 sc-201225C sc-201225A sc-201225B | 1 mg 5 mg 10 mg 50 mg | $56.00 $156.00 $270.00 $665.00 | 37 | |
PGE2, a prostaglandin involved in inflammation and a substrate for AKR enzymes, directly activates AKR7A4 by serving as a substrate for its enzymatic activity. | ||||||
1,1-Dimethylbiguanide, Hydrochloride | 1115-70-4 | sc-202000 sc-202000A sc-202000B sc-202000C sc-202000D sc-202000E | 1 g 5 g 10 g 50 g 100 g 250 g | $30.00 $42.00 $62.00 $153.00 $255.00 $500.00 | 37 | |
A drug used to treat diabetes that indirectly activates AKR7A4 by modulating glucose and insulin metabolism, which can influence the availability of cofactors and substrates for the enzyme's catalysis. | ||||||