NADPH tetrasodium salt (CAS 2646-71-1)
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NADPH Tetrasodium Salt is a form of Nicotinamide Adenine Dinucleotide Phosphate (NADPH) where the sodium salt enhances its solubility, facilitating its use in various biochemical assays. In research, NADPH is a critical cofactor involved in reductive biosynthesis, antioxidant defense by regenerating reduced glutathione, and in detoxification processes within cells. It is widely used in studies of enzyme kinetics, where it serves as a reducing agent for enzymes requiring electron donation, such as those in the cytochrome P450 system. NADPH is also essential in the study of oxidative stress mechanisms, as it is a substrate for NADPH oxidase, which plays a role in the generation of reactive oxygen species. Furthermore, NADPH is used in the examination of metabolic pathways that require reduction, such as fatty acid, cholesterol, and steroid biosynthesis. The tetrasodium salt form is particularly advantageous in aqueous solutions, enabling more accurate and efficient incorporation into experimental protocols.
NADPH tetrasodium salt (CAS 2646-71-1) References
- Biological roles for the NOX family NADPH oxidases. | Nauseef, WM. 2008. J Biol Chem. 283: 16961-5. PMID: 18420576
- Structure, regulation and evolution of Nox-family NADPH oxidases that produce reactive oxygen species. | Sumimoto, H. 2008. FEBS J. 275: 3249-77. PMID: 18513324
- Patients with rheumatoid arthritis treated with methotrexate (MTX): concentrations of steady-state erythrocyte MTX correlate to plasma concentrations and clinical efficacy. | Hornung, N., et al. 2008. J Rheumatol. 35: 1709-15. PMID: 18634162
- The association of elevated reactive oxygen species levels from neutrophils with low-grade inflammation in the elderly. | Ogawa, K., et al. 2008. Immun Ageing. 5: 13. PMID: 18950479
- NADPH oxidases: functions and pathologies in the vasculature. | Lassègue, B. and Griendling, KK. 2010. Arterioscler Thromb Vasc Biol. 30: 653-61. PMID: 19910640
- Peptide-based inhibitors of the phagocyte NADPH oxidase. | El-Benna, J., et al. 2010. Biochem Pharmacol. 80: 778-85. PMID: 20510204
- Inhibition kinetics of acetylcholinesterase with fluoromethyl ketones. | Allen, KN. and Abeles, RH. 1989. Biochemistry. 28: 8466-73. PMID: 2605196
- Antioxidants reduce reactive oxygen species but not embryotoxicity in the metabolic Danio rerio test (mDarT). | Pype, C., et al. 2017. Reprod Toxicol. 72: 62-73. PMID: 28663077
- Effects of t-butyl hydroperoxide on NADPH, glutathione, and the respiratory burst of rat alveolar macrophages. | Sutherland, MW., et al. 1985. Arch Biochem Biophys. 243: 325-31. PMID: 3002274
- Ligation-Based qPCR-Amplification Assay for Radiolabel-Free Detection of ATP and NAD+ with High Selectivity and Sensitivity. | Zhang, X., et al. 2019. Anal Chem. 91: 1665-1670. PMID: 30572701
- HMG-CoA Reductase as Target for Drug Development. | Gunasekaran, B. and Shukor, MY. 2020. Methods Mol Biol. 2089: 245-250. PMID: 31773659
- Atypical kinetics of cytochrome P450 2J2: Epoxidation of arachidonic acid and reversible inhibition by xenobiotic inhibitors. | Leow, JWH., et al. 2021. Eur J Pharm Sci. 164: 105889. PMID: 34044117
- Citalopram and Cannabidiol: In Vitro and In Vivo Evidence of Pharmacokinetic Interactions Relevant to the Treatment of Anxiety Disorders in Young People. | Anderson, LL., et al. J Clin Psychopharmacol. 41: 525-533. PMID: 34121064
- Functional Characterization and Structural Insights Into Stereoselectivity of Pulegone Reductase in Menthol Biosynthesis. | Liu, C., et al. 2021. Front Plant Sci. 12: 780970. PMID: 34917113
- Estimation of chlorzoxazone hydroxylase activity in liver microsomes and of the plasma pharmacokinetics of chlorzoxazone by the same high-performance liquid chromatographic method. | Leclercq, I., et al. 1998. J Chromatogr A. 828: 291-6. PMID: 9916314
Ordering Information
| Product Name | Catalog # | UNIT | Price | Qty | FAVORITES | |
NADPH tetrasodium salt, 25 mg | sc-202725 | 25 mg | $46.00 | |||
NADPH tetrasodium salt, 50 mg | sc-202725A | 50 mg | $82.00 | |||
NADPH tetrasodium salt, 250 mg | sc-202725B | 250 mg | $280.00 | |||
NADPH tetrasodium salt, 1 g | sc-202725C | 1 g | $754.00 |