ADK Activators
The chemical class of ADK activators consists of a diverse range of compounds that indirectly influence the activity of Adenosine Kinase through various pathways related to nucleotide metabolism. These activators, which include both nucleotide analogs and drugs affecting nucleotide synthesis pathways, highlight the complex interplay between nucleotide metabolism and the regulation of key enzymes like ADK.
Compounds such as adenosine, methotrexate, and ribavirin are notable in this class for their roles in influencing nucleotide pools and metabolism. Adenosine, being a substrate of ADK, can lead to increased ADK activity as a compensatory response to high intracellular levels. Methotrexate and ribavirin, through their impact on purine and pyrimidine metabolism, can indirectly lead to alterations in ADK activity. These compounds demonstrate how changes in nucleotide synthesis and availability can indirectly modulate enzyme activities within the same metabolic pathway. Immunosuppressants and chemotherapy agents like mycophenolate mofetil, azathioprine, and clofarabine also play a significant role in this class. By impacting nucleotide synthesis pathways, these drugs can lead to changes in the nucleotide pool balance, influencing ADK activity. This indirect modulation underscores the complexity of nucleotide metabolism regulation.
Items 1 to 10 of 11 total
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| Product Name | CAS # | Catalog # | QUANTITY | Price | Citations | RATING |
|---|---|---|---|---|---|---|
Adenosine | 58-61-7 | sc-291838 sc-291838A sc-291838B sc-291838C sc-291838D sc-291838E sc-291838F | 1 g 5 g 100 g 250 g 1 kg 5 kg 10 kg | $33.00 $47.00 $294.00 $561.00 $1020.00 $2550.00 $4590.00 | 1 | |
While adenosine is a substrate for ADK, high levels of adenosine can potentially lead to an increase in ADK activity as a compensatory mechanism to regulate adenosine levels in the cell. | ||||||
Methotrexate | 59-05-2 | sc-3507 sc-3507A | 100 mg 500 mg | $92.00 $209.00 | 33 | |
As an antifolate drug, methotrexate can impact purine metabolism, which might lead to an indirect increase in ADK activity due to alterations in nucleotide pools and balances. | ||||||
Mycophenolate mofetil | 128794-94-5 | sc-200971 sc-200971A | 20 mg 100 mg | $36.00 $107.00 | 1 | |
This immunosuppressant inhibits inosine monophosphate dehydrogenase, potentially leading to changes in nucleotide metabolism that could indirectly increase ADK activity. | ||||||
Azathioprine | 446-86-6 | sc-210853D sc-210853 sc-210853A sc-210853B sc-210853C | 500 mg 1 g 2 g 5 g 10 g | $199.00 $173.00 $342.00 $495.00 $690.00 | 1 | |
affects purine metabolism, potentially leading to indirect modulation of ADK activity through altered nucleotide synthesis pathways. | ||||||
Fluorouracil | 51-21-8 | sc-29060 sc-29060A | 1 g 5 g | $36.00 $149.00 | 11 | |
A chemotherapy agent that interferes with pyrimidine metabolism, potentially influencing ADK activity indirectly by altering nucleotide pools. | ||||||
Hydroxyurea | 127-07-1 | sc-29061 sc-29061A | 5 g 25 g | $76.00 $255.00 | 18 | |
This agent inhibits ribonucleotide reductase, potentially leading to changes in nucleotide pools that could indirectly influence ADK activity. | ||||||
Allopurinol | 315-30-0 | sc-207272 | 25 g | $128.00 | ||
A xanthine oxidase inhibitor that affects purine metabolism, potentially leading to indirect modulation of ADK activity through alterations in purine synthesis. | ||||||
Clofarabine | 123318-82-1 | sc-278864 sc-278864A | 10 mg 50 mg | $185.00 $781.00 | ||
A purine nucleoside analog used in chemotherapy, potentially affecting ADK activity indirectly through its impact on nucleotide synthesis and metabolism. | ||||||
2-Chloro-2′-deoxyadenosine | 4291-63-8 | sc-202399 | 10 mg | $144.00 | 1 | |
Another purine nucleoside analog affecting purine metabolism, which might indirectly increase ADK activity by influencing nucleotide pools. | ||||||
Fludarabine | 21679-14-1 | sc-204755 sc-204755A | 5 mg 25 mg | $57.00 $200.00 | 15 | |
A chemotherapy drug that is a purine analog, potentially influencing ADK activity indirectly through its effects on nucleotide metabolism. | ||||||