ADAM25 Activators
ADAM25 Activators comprise a diverse array of chemical compounds that indirectly enhance the functional activity of ADAM25 through modulation of various biochemical pathways and processes. Metalloprotease inhibitors such as Hydroxamic Acid, Batimastat, Marimastat, and Ilomastat, by chelating zinc at the active site or by inhibiting proteolytic degradation, preserve the protease functionality of ADAM25. PMA, a diacylglycerol analog, activates protein kinase C, which in turn may phosphorylate and increase the trafficking of ADAM25 to the cell membrane, thereby enhancing its proteolytic activity. Calcium Ionophore A23187 and Ionomycin elevate intracellular calcium concentrations, which could enhance the maturation and membrane translocation of ADAM25, as calcium signaling is crucial for the activation of many proteases.
Similarly, Retinoic Acid might upregulate the expression of ADAM25 gene, producing more of the protein for subsequent activation, while EGF through EGFR signaling could lead to phosphorylation events that activate ADAM25's shedding functions. Heparin, by stabilizing ADAM25, might enhance its interaction with substrates at the cell surface, and N-Acetylcysteine, by reducing oxidative stress, preserves the functional conformation of the protease, maintaining its activity. Furthermore, Glutathione, as an antioxidant, may protect ADAM25 from oxidative damage, ensuring the protease remains active.
SEE ALSO...
| Product Name | CAS # | Catalog # | QUANTITY | Price | Citations | RATING |
|---|---|---|---|---|---|---|
Batimastat | 130370-60-4 | sc-203833 sc-203833A | 1 mg 10 mg | $179.00 $377.00 | 24 | |
Batimastat is a broad-spectrum matrix metalloprotease inhibitor that could prevent the auto-degradation of ADAM25, thereby preserving its functional activity. | ||||||
Marimastat | 154039-60-8 | sc-202223 sc-202223A sc-202223B sc-202223C sc-202223E | 5 mg 10 mg 25 mg 50 mg 400 mg | $168.00 $218.00 $404.00 $629.00 $4900.00 | 19 | |
Marimastat is another broad-spectrum metalloprotease inhibitor that may indirectly enhance ADAM25 activity by stabilizing its structure against proteolytic degradation. | ||||||
GM 6001 | 142880-36-2 | sc-203979 sc-203979A | 1 mg 5 mg | $77.00 $270.00 | 55 | |
Ilomastat, a matrix metalloprotease inhibitor, could help maintain the structural integrity of ADAM25, thus potentially enhancing its proteolytic activity. | ||||||
PMA | 16561-29-8 | sc-3576 sc-3576A sc-3576B sc-3576C sc-3576D | 1 mg 5 mg 10 mg 25 mg 100 mg | $41.00 $132.00 $214.00 $500.00 $948.00 | 119 | |
PMA is a diacylglycerol analog that activates protein kinase C (PKC), which can phosphorylate ADAM25, potentially increasing its proteolytic activity by enhancing its trafficking to the cell membrane. | ||||||
A23187 | 52665-69-7 | sc-3591 sc-3591B sc-3591A sc-3591C | 1 mg 5 mg 10 mg 25 mg | $55.00 $131.00 $203.00 $317.00 | 23 | |
Calcium ionophore A23187 increases intracellular calcium concentration, which might promote ADAM25 activity by facilitating the protease's maturation and membrane translocation due to calcium-dependent signaling. | ||||||
Retinoic Acid, all trans | 302-79-4 | sc-200898 sc-200898A sc-200898B sc-200898C | 500 mg 5 g 10 g 100 g | $66.00 $325.00 $587.00 $1018.00 | 28 | |
Retinoic acid can regulate gene expression and may enhance the expression of ADAM25, indirectly increasing the availability of functional protein. | ||||||
Heparin | 9005-49-6 | sc-507344 | 25 mg | $119.00 | 1 | |
Heparin, a glycosaminoglycan, can bind to and stabilize ADAM25, which might enhance its proteolytic function on the cell surface. | ||||||
N-Acetyl-L-cysteine | 616-91-1 | sc-202232 sc-202232A sc-202232C sc-202232B | 5 g 25 g 1 kg 100 g | $34.00 $74.00 $270.00 $114.00 | 34 | |
N-Acetylcysteine can reduce oxidative stress, which may preserve the functional conformation of ADAM25, enhancing its activity. | ||||||
Ionomycin | 56092-82-1 | sc-3592 sc-3592A | 1 mg 5 mg | $78.00 $270.00 | 80 | |
Ionomycin is a calcium ionophore that elevates intracellular calcium levels, potentially enhancing ADAM25 activity through calcium-dependent protease activation. | ||||||
Glutathione, reduced | 70-18-8 | sc-29094 sc-29094A | 10 g 1 kg | $82.00 $2091.00 | 8 | |
Glutathione is an antioxidant that may protect ADAM25 from oxidative damage, thereby maintaining its activity. | ||||||