ACTR6 Activators
The complex nature of chromatin dynamics necessitates a host of molecules to modulate its structure and function. The aforementioned chemicals are integral to this, specifically concerning their interaction with ACTR6. Chromatin remodeling is a dynamic process that can be influenced by histone modifications, DNA methylation, and the activity of various chromatin-associated complexes. A majority of the chemicals listed, such as Anacardic Acid and Trichostatin A (TSA), have a direct impact on these modifications and consequently on the chromatin landscape. For instance, TSA, being a histone deacetylase, promotes histone acetylation leading to an open chromatin state, which can facilitate the function of ACTR6 in the SWR1 complex.
Chemicals like C646 and Garcinol inhibit the histone acetyltransferases p300/CBP, altering the balance of histone acetylation in the cell. This modulation is essential as it dictates the accessibility of chromatin to transcription factors and other associated proteins. ACTR6's involvement in the SWR1 complex, which has a role in histone exchange and positioning, means that changes in chromatin accessibility can influence its function. Furthermore, compounds such as EPZ004777 and GSK126 that modulate histone methylation states indirectly affect the chromatin landscape and subsequently ACTR6's function. By understanding the nuanced interplay of these chemicals with chromatin modifiers and remodelers, we can appreciate the multi-layered regulation of ACTR6.
SEE ALSO...
Items 1 to 10 of 11 total
Display:
| Product Name | CAS # | Catalog # | QUANTITY | Price | Citations | RATING |
|---|---|---|---|---|---|---|
Anacardic Acid | 16611-84-0 | sc-202463 sc-202463A | 5 mg 25 mg | $100.00 $200.00 | 13 | |
Anacardic acid has been shown to activate the SWI/SNF chromatin-remodeling complexes. Activation of these complexes can lead to chromatin changes that potentially affect ACTR6 function as part of the SWR1 complex. | ||||||
Trichostatin A | 58880-19-6 | sc-3511 sc-3511A sc-3511B sc-3511C sc-3511D | 1 mg 5 mg 10 mg 25 mg 50 mg | $149.00 $470.00 $620.00 $1199.00 $2090.00 | 33 | |
TSA is a histone deacetylase (HDAC) inhibitor. By inhibiting HDAC activity, it promotes histone acetylation leading to an open chromatin state. This can promote the action of chromatin remodeling proteins like ACTR6. | ||||||
5-Azacytidine | 320-67-2 | sc-221003 | 500 mg | $280.00 | 4 | |
DNA methyltransferase inhibitor. By reducing DNA methylation, it promotes a more open chromatin structure. ACTR6, being part of the chromatin remodeling complex, can be affected by these chromatin state changes. | ||||||
Sodium Butyrate | 156-54-7 | sc-202341 sc-202341B sc-202341A sc-202341C | 250 mg 5 g 25 g 500 g | $30.00 $46.00 $82.00 $218.00 | 19 | |
Histone deacetylase inhibitor that results in hyperacetylation of histones. This chemical modification can facilitate the action of chromatin remodelers such as ACTR6 in the SWR1 complex. | ||||||
C646 | 328968-36-1 | sc-364452 sc-364452A | 10 mg 50 mg | $260.00 $925.00 | 5 | |
A selective p300/CBP histone acetyltransferase inhibitor. Inhibition of p300/CBP can shift the balance of histone acetylation and influence ACTR6 chromatin remodeling functions. | ||||||
Garcinol | 78824-30-3 | sc-200891 sc-200891A | 10 mg 50 mg | $136.00 $492.00 | 13 | |
An inhibitor of p300/CBP histone acetyltransferase. Similar to C646, garcinol can influence the balance of histone modifications, which can indirectly modulate the function of ACTR6. | ||||||
PFI 3 | 1819363-80-8 | sc-507340 | 10 mg | $300.00 | ||
A selective inhibitor of the bromodomains of SMARCA2 and SMARCA4, components of the SWI/SNF chromatin-remodeling complex. By modulating these proteins, PFI-3 can influence ACTR6's chromatin remodeling activity. | ||||||
BAY-876 | 1799753-84-6 | sc-507539 | 5 mg | $240.00 | ||
Glucose transporter inhibitor. While its primary function is not directly linked to chromatin remodeling, changes in cellular glucose levels can indirectly affect various cellular processes including those involving ACTR6. | ||||||
Epz004777 | 1338466-77-5 | sc-507560 | 100 mg | $575.00 | ||
DOT1L histone methyltransferase inhibitor. By influencing histone methylation states, this compound can indirectly modulate the function of chromatin remodelers like ACTR6. | ||||||
GSK126 | 1346574-57-9 | sc-490133 sc-490133A sc-490133B | 1 mg 5 mg 10 mg | $90.00 $238.00 $300.00 | ||
EZH2 methyltransferase inhibitor. Changes in histone methylation can alter the chromatin landscape, potentially influencing ACTR6's role in the SWR1 complex. | ||||||