ACTR6 Inhibitors
ACTR6 inhibitors are a class of chemical compounds designed to target the ACTR6 (ARP6 actin-related protein 6) protein, which is part of the SWR1 chromatin remodeling complex. ACTR6 plays a key role in chromatin remodeling, a process essential for regulating DNA accessibility in eukaryotic cells. As a member of the SWR1 complex, ACTR6 helps in the exchange of histone H2A with the H2A.Z variant, a process critical for gene expression regulation, DNA repair, and chromatin structure maintenance. By inhibiting ACTR6, compounds within this class can modulate chromatin dynamics, potentially altering the accessibility of specific genomic regions for transcriptional machinery or other DNA-binding proteins.
From a chemical perspective, ACTR6 inhibitors may be designed to disrupt the protein's ability to interact with other subunits of the SWR1 complex or to interfere with its actin-related activities within chromatin remodeling processes. These inhibitors could bind to functional domains on ACTR6, such as regions critical for ATP hydrolysis or binding to other actin-related proteins within the complex. The development of ACTR6 inhibitors would involve advanced structural biology techniques, such as X-ray crystallography or cryo-electron microscopy, to understand the binding sites and conformational states of the protein. High-throughput screening techniques would likely be used to identify candidate compounds, followed by structure-activity relationship (SAR) studies to enhance their specificity and binding affinity. The study of ACTR6 inhibitors contributes to a deeper understanding of chromatin biology and the molecular mechanisms governing gene expression regulation and DNA accessibility.
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| Product Name | CAS # | Catalog # | QUANTITY | Price | Citations | RATING |
|---|---|---|---|---|---|---|
Hydroxyurea | 127-07-1 | sc-29061 sc-29061A | 5 g 25 g | $76.00 $255.00 | 18 | |
Hydroxyurea inhibits ribonucleotide reductase, which can affect DNA synthesis and chromatin assembly. By impeding proper chromatin formation, it may indirectly hinder ACTR6's remodeling activity as part of the SWR1 complex. | ||||||
Curcumin | 458-37-7 | sc-200509 sc-200509A sc-200509B sc-200509C sc-200509D sc-200509F sc-200509E | 1 g 5 g 25 g 100 g 250 g 1 kg 2.5 kg | $36.00 $68.00 $107.00 $214.00 $234.00 $862.00 $1968.00 | 47 | |
Curcumin has been shown to inhibit histone acetyltransferases (HATs), which control histone acetylation levels. Decreased acetylation can result in closed chromatin, potentially limiting ACTR6's chromatin remodeling functions. | ||||||
Valproic Acid | 99-66-1 | sc-213144 | 10 g | $85.00 | 9 | |
Primarily known as an anticonvulsant, Valproic Acid is also an HDAC inhibitor. Its mechanism can lead to chromatin condensation, potentially limiting ACTR6's effectiveness in remodeling. | ||||||
M 344 | 251456-60-7 | sc-203124 sc-203124A | 1 mg 5 mg | $107.00 $316.00 | 8 | |
M344 is an HDAC inhibitor. By increasing histone acetylation, it can condense chromatin structure and could potentially challenge ACTR6's chromatin remodeling activity. | ||||||
Nicotinamide | 98-92-0 | sc-208096 sc-208096A sc-208096B sc-208096C | 100 g 250 g 1 kg 5 kg | $43.00 $65.00 $200.00 $815.00 | 6 | |
This compound inhibits the activity of sirtuins, a class of HDACs. The inhibition of sirtuins may modify chromatin structure in a way that restricts ACTR6's functionality. | ||||||
BIX01294 hydrochloride | 1392399-03-9 | sc-293525 sc-293525A sc-293525B | 1 mg 5 mg 25 mg | $36.00 $110.00 $400.00 | ||
It's a specific inhibitor of G9a histone methyltransferase. Altering histone methylation states can change the chromatin landscape and potentially limit the function of chromatin remodelers like ACTR6. | ||||||
3-Deazaneplanocin, HCl salt | 120964-45-6 | sc-351856 sc-351856A sc-351856B | 1 mg 5 mg 10 mg | $251.00 $600.00 $918.00 | 2 | |
It inhibits histone methylation by reducing the levels of EZH2. Changes in chromatin methylation can modulate the function of associated remodelers, including ACTR6. | ||||||
Disulfiram | 97-77-8 | sc-205654 sc-205654A | 50 g 100 g | $52.00 $87.00 | 7 | |
While known as an alcohol-aversive drug, Disulfiram has been shown to affect histone modifications, potentially impacting ACTR6's chromatin remodeling activities. | ||||||
Scriptaid | 287383-59-9 | sc-202807 sc-202807A | 1 mg 5 mg | $63.00 $179.00 | 11 | |
Another HDAC inhibitor, Scriptaid affects histone acetylation states. Changes in chromatin accessibility can influence the role of ACTR6 in chromatin remodeling. | ||||||
Parthenolide | 20554-84-1 | sc-3523 sc-3523A | 50 mg 250 mg | $79.00 $300.00 | 32 | |
This compound can alter histone modifications, particularly acetylation, which can impact the chromatin state and indirectly influence ACTR6's function. | ||||||