AChR α 7 Activators
Items 1 to 10 of 15 total
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| Product Name | CAS # | Catalog # | QUANTITY | Price | Citations | RATING |
|---|---|---|---|---|---|---|
PNU-282,987 | 123464-89-1 | sc-200187 sc-200187A | 10 mg 50 mg | $170.00 $576.00 | 3 | |
PNU-282,987 is a potent agonist of the alpha-7 nicotinic acetylcholine receptor, exhibiting a high affinity for this target. Its unique structural features facilitate specific hydrogen bonding and hydrophobic interactions, promoting receptor activation. The compound demonstrates a remarkable ability to modulate ion channel dynamics, leading to enhanced calcium influx. Additionally, its rapid dissociation kinetics allow for precise temporal control of receptor signaling, influencing various intracellular pathways. | ||||||
Cytisine | 485-35-8 | sc-203015 sc-203015A | 5 mg 25 mg | $56.00 $190.00 | ||
Cytisine acts as a selective agonist for the alpha-7 nicotinic acetylcholine receptor, characterized by its unique ability to stabilize receptor conformations through specific electrostatic interactions. This compound engages in distinct allosteric modulation, influencing the receptor's ion permeability and facilitating a nuanced calcium signaling cascade. Its interaction kinetics reveal a balance between affinity and dissociation, allowing for dynamic regulation of synaptic transmission and neuronal excitability. | ||||||
Retinoic Acid, all trans | 302-79-4 | sc-200898 sc-200898A sc-200898B sc-200898C | 500 mg 5 g 10 g 100 g | $66.00 $325.00 $587.00 $1018.00 | 28 | |
Retinoic acid can impact α7 nAChR expression through its effects on gene transcription and neuronal development. | ||||||
Tropisetron hydrochloride | 105826-92-4 | sc-204930 sc-204930A | 10 mg 50 mg | $96.00 $571.00 | 2 | |
Tropisetron hydrochloride exhibits a unique affinity for the alpha-7 nicotinic acetylcholine receptor, engaging in specific hydrogen bonding and hydrophobic interactions that enhance receptor activation. Its molecular structure allows for selective binding, influencing downstream signaling pathways and modulating neurotransmitter release. The compound's reaction kinetics demonstrate a rapid onset of action, with a distinctive profile of receptor desensitization that contributes to its regulatory effects on synaptic activity. | ||||||
NS 1738 | 501684-93-1 | sc-204136 sc-204136A | 10 mg 50 mg | $149.00 $620.00 | 1 | |
NS 1738 is a selective modulator of the alpha-7 nicotinic acetylcholine receptor, characterized by its ability to stabilize the receptor's active conformation through unique electrostatic interactions. This compound exhibits a distinct binding affinity that promotes enhanced ion channel conductance, facilitating calcium influx. Its kinetic profile reveals a fast association rate, coupled with a prolonged dissociation phase, which influences receptor dynamics and synaptic plasticity. | ||||||
PHA 568487 | 527680-56-4 | sc-204186 sc-204186A | 10 mg 50 mg | $101.00 $575.00 | 1 | |
PHA 568487 is a selective allosteric modulator of the alpha-7 nicotinic acetylcholine receptor, distinguished by its ability to induce conformational changes that enhance receptor sensitivity to acetylcholine. This compound engages in specific hydrophobic interactions that stabilize the receptor's open state, leading to increased ion permeability. Its unique reaction kinetics demonstrate a rapid onset of action, with a notable impact on downstream signaling pathways, influencing neuronal excitability and synaptic transmission. | ||||||
Galanthamine | 357-70-0 | sc-218556 | 10 mg | $320.00 | ||
Galantamine enhances α7 nAChR function and potentially support cognitive function. | ||||||
PNU-282987 hydrate | 123464-89-1 (anhydrous) | sc-301554 | 10 mg | $139.00 | ||
PNU-282987 hydrate acts as a potent allosteric modulator of the alpha-7 nicotinic acetylcholine receptor, characterized by its ability to selectively enhance receptor activation. This compound exhibits unique binding dynamics, promoting a distinct conformational state that facilitates ion channel opening. Its interaction profile reveals a preference for specific amino acid residues, leading to altered receptor kinetics and modulation of intracellular calcium levels, thereby influencing synaptic plasticity. | ||||||
AR-R17779 HCl | 178419-42-6 | sc-337535 | 10 mg | $440.00 | ||
AR-R17779 HCl functions as a selective agonist for the alpha-7 nicotinic acetylcholine receptor, exhibiting a unique mechanism of action through its preferential binding to the receptor's orthosteric site. This compound induces a conformational shift that enhances ion permeability, resulting in increased calcium influx. Its kinetic profile suggests rapid receptor activation and desensitization, influencing downstream signaling pathways and synaptic transmission efficiency. | ||||||
A 582941 | 848591-90-2 | sc-362706 sc-362706A | 10 mg 50 mg | $195.00 $825.00 | 2 | |
A 582941 acts as a selective modulator of the alpha-7 nicotinic acetylcholine receptor, characterized by its ability to stabilize receptor conformations that promote enhanced ligand affinity. This compound exhibits unique allosteric interactions, facilitating a nuanced regulation of ion channel activity. Its reaction kinetics reveal a distinct pattern of receptor engagement, leading to prolonged signaling cascades and modulation of neurotransmitter release, thereby influencing synaptic plasticity. | ||||||