Tropisetron hydrochloride CAS: 105826-92-4
MF: C17H20N2O2 HCl
Tropisetron hydrochloride is a potent SR-3 antagonist.

Tropisetron hydrochloride (CAS 105826-92-4)

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Alternate Names: (3-endo)-8-Methyl-8-azabicyclo[3.2.1]oct-3-yl 1H-indole-3-carboxylic acid ester monohydrochloride
Application: Tropisetron hydrochloride is a potent SR-3 antagonist
CAS Number: 105826-92-4
Purity: ≥99%
Molecular Weight: 320.82
Molecular Formula: C17H20N2O2 HCl
Supplemental Information: This is classified as a Dangerous Good for transport and may be subject to additional shipping charges.
For Research Use Only. Not Intended for Diagnostic or Therapeutic Use.
* Refer to Certificate of Analysis for lot specific data (including water content).

Tropisetron hydrochloride is a potent SR (SR-3) antagonist. It is also a selective, partial agonist at AChR α 7 (α7 nicotinic receptors). Tropisetron hydrochloride is an inhibitor of HTR3.


References

Tonini M, Candura SM Onori L et al. Life Sci. 50:PL173-8 (1992). Seynaeve et al (1991) 5-HT3 receptor antagonists, a new approach in emesis: a review of ondansetron, granisetron and tropisetron. Anticancer Drugs 2 343. Middlemiss and Tricklebank (1992) Ce

Appearance :
Crystalline
Physical State :
Solid
Solubility :
Soluble in water (100 mM), DMSO (50 mM), and methanol.
Storage :
Store at 4° C
Melting Point :
283-285° C (dec.)
Boiling Point :
448.5° C at 760 mmHg (Predicted)
Density :
1.40 g/cm3
Refractive Index :
n20D 1.64 (Predicted)
For Research Use Only. Not Intended for Diagnostic or Therapeutic Use.
WGK Germany :
3
RTECS :
NL6012520
PubChem CID :
9818540
Merck Index :
14: 9783
MDL Number :
MFCD00210221
SMILES :
CN1C2CCC1CC(C2)OC(=O)C3=CNC4=CC=CC=C43.Cl

Download SDS (MSDS)

Certificate of Analysis

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PMID: # 25377620  Maehara, T. et al. 2015. Br. J. Pharmacol. 172: 1136-47.

Citations 1 to 1 of 1 total
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