Molecular structure of AR-R17779 HCl, CAS Number: 178419-42-6
AR-R17779 HCl (CAS 178419-42-6)
Application:
AR-R17779 HCl is a selective agonist of α7 AChRs
CAS Number:
178419-42-6
Purity:
≥99%
Molecular Weight:
218.68
Molecular Formula:
C9H14N2O2•HCl
For Research Use Only. Not Intended for Diagnostic or Therapeutic Use.
* Refer to Certificate of Analysis for lot specific data.
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Description
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SDS & Certificate of Analysis
AR-R17779 HCl is a selective agonist of α7 AChRs (Ki values are 190 and 16000 nM for rat α7 and α4β2 receptors, respectively).
AR-R17779 HCl (CAS 178419-42-6) References
- AR-R17779, and alpha7 nicotinic agonist, improves learning and memory in rats. | Levin, ED., et al. 1999. Behav Pharmacol. 10: 675-80. PMID: 10780509
- (-)-Spiro[1-azabicyclo[2.2.2]octane-3,5'-oxazolidin-2'-one], a conformationally restricted analogue of acetylcholine, is a highly selective full agonist at the alpha 7 nicotinic acetylcholine receptor. | Mullen, G., et al. 2000. J Med Chem. 43: 4045-50. PMID: 11063601
- The DBA/2J strain and prepulse inhibition of startle: a model system to test antipsychotics? | Olivier, B., et al. 2001. Psychopharmacology (Berl). 156: 284-90. PMID: 11549230
- AR-R 17779 improves social recognition in rats by activation of nicotinic alpha7 receptors. | Van Kampen, M., et al. 2004. Psychopharmacology (Berl). 172: 375-83. PMID: 14727003
- Activity of alpha7-selective agonists at nicotinic and serotonin 5HT3 receptors expressed in Xenopus oocytes. | Papke, RL., et al. 2004. Bioorg Med Chem Lett. 14: 1849-53. PMID: 15050614
- Activation of the cholinergic anti-inflammatory pathway ameliorates postoperative ileus in mice. | The, FO., et al. 2007. Gastroenterology. 133: 1219-28. PMID: 17919496
- Stimulation of nicotinic acetylcholine receptors attenuates collagen-induced arthritis in mice. | van Maanen, MA., et al. 2009. Arthritis Rheum. 60: 114-22. PMID: 19116908
- Selective alpha7 nicotinic acetylcholine receptor agonists worsen disease in experimental colitis. | Snoek, SA., et al. 2010. Br J Pharmacol. 160: 322-33. PMID: 20423343
- Stimulation of α7 nicotinic acetylcholine receptor by AR-R17779 suppresses atherosclerosis and aortic aneurysm formation in apolipoprotein E-deficient mice. | Hashimoto, T., et al. 2014. Vascul Pharmacol. 61: 49-55. PMID: 24685818
- Involvement of Mast Cells in α7 Nicotinic Receptor Agonist Exacerbation of Freund's Complete Adjuvant-Induced Monoarthritis in Mice. | Lopes, F., et al. 2016. Arthritis Rheumatol. 68: 542-52. PMID: 26314943
- Suppression of abdominal aortic aneurysm formation by AR-R17779, an agonist for the α7 nicotinic acetylcholine receptor. | Watanabe, A., et al. 2016. Atherosclerosis. 244: 113-20. PMID: 26613536
- α7 Nicotinic Agonist AR-R17779 Protects Mice against 2,4,6-Trinitrobenzene Sulfonic Acid-Induced Colitis in a Spleen-Dependent Way. | Grandi, A., et al. 2017. Front Pharmacol. 8: 809. PMID: 29167641
- The selective alpha7 nicotinic acetylcholine receptor agonist AR-R17779 does not affect ischemia-reperfusion brain injury in mice. | Hammarlund, ME., et al. 2021. Biosci Rep. 41: PMID: 34008839
- Precision targeting of the vagal anti-inflammatory pathway attenuates the systemic inflammatory response to burn injury. | Costantini, TW., et al. 2022. J Trauma Acute Care Surg. 92: 323-329. PMID: 34789702
- Mesenchymal stromal cells alleviate acute respiratory distress syndrome through the cholinergic anti-inflammatory pathway. | Zhang, X., et al. 2022. Signal Transduct Target Ther. 7: 307. PMID: 36064538
Inhibitor of:
AChRα5.Activator of:
AChR α 7.Ordering Information
| Product Name | Catalog # | UNIT | Price | Qty | FAVORITES | |
AR-R17779 HCl, 10 mg | sc-337535 | 10 mg | $440.00 |