PNU-282,987 CAS: 123464-89-1
MF: C14H17ClN2O
MW: 264.75
A highly selective α7 nicotinic acetylcholine receptor agonist.

PNU-282,987 (CAS 123464-89-1)

PNU-282,987 | CAS 123464-89-1 is rated 5.0 out of 5 by 1.
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Application: A highly selective α7 nicotinic acetylcholine receptor agonist
CAS Number: 123464-89-1
Purity: ≥98%
Molecular Weight: 264.75
Molecular Formula: C14H17ClN2O
For Research Use Only. Not Intended for Diagnostic or Therapeutic Use.
* Refer to Certificate of Analysis for lot specific data (including water content).

PNU-282,987 is a highly selective agonist for the homomeric α7 nicotinic acetylcholine receptor (α7 nAChR). This novel agonist of the α7 nAChR has been utilized in multiple model brain investigations of this receptor. Utilizing PNU-282,987 has been reported to evoke whole-cell currents. PNU-282,987 is hypothesized to modulate or enhance GABAergic hippocampal neurotransmission. PNU-282,987 has also been used in various studies to investigate the effects of the compound on hippocampal theta oscillation in vitro.


References

1. Hajos, M., et al. 2005. J. Pharmacol. Exp. Ther. 312: 1213-1233. PMID: 15523001
2. Siok, C. J., et al. 2006. Eur. J. Neurosci. 23: 570-574. PMID: 16420464
3. Taslim, N. and Saeed Dar, M. 2010. Alcohol Clin Exp Res. [Epub ahead of print]. PMID: 21143250
4. Maloku, E., et al. 2011. Neuropsychopharmacology. 36: 1366-1374. PMID: 21368748

Physical State :
Solid
Solubility :
Soluble in DMSO (20 mg/mL), water (6 mg/mL) and ethanol (6 mg/mL)
Storage :
Store at room temperature
Melting Point :
240-242° C
Boiling Point :
~431.5° C at 760 mmHg (Predicted)
Density :
~1.3 g/cm3 (Predicted)
For Research Use Only. Not Intended for Diagnostic or Therapeutic Use.
PubChem CID :
9795278
SMILES :
C1CN2CCC1[[email protected]](C2)NC(=O)C3=CC=C(C=C3)Cl

Download SDS (MSDS)

Certificate of Analysis

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PNU-282,987 (CAS 123464-89-1)  Product Citations

See how others have used PNU-282,987 (CAS 123464-89-1). Click on the entry to view the PubMed entry .

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PMID: # 22820264  Neuroscience. 222: 10-9.

Citations 1 to 1 of 1 total
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Rated 5 out of 5 by from Waldburger JM; et al Waldburger JM; et al. (PubMed ID: 18975306) determined that PNU-282,987 caused the production of IL-6 to decrease due to IL-1-stimulated fibroblast-like synoviocytes. -SCBT Publication Review
Date published: 2015-04-08
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