PNU-282,987 is a highly selective agonist for the homomeric α7 nicotinic acetylcholine receptor (α7 nAChR). This novel agonist of the α7 nAChR has been utilized in multiple model brain investigations of this receptor. Utilizing PNU-282,987 has been reported to evoke whole-cell currents. PNU-282,987 is hypothesized to modulate or enhance GABAergic hippocampal neurotransmission. PNU-282,987 has also been used in various studies to investigate the effects of the compound on hippocampal theta oscillation in vitro.
1. Hajos, M., et al. 2005. J. Pharmacol. Exp. Ther. 312: 1213-1233. PMID: 15523001 2. Siok, C. J., et al. 2006. Eur. J. Neurosci. 23: 570-574. PMID: 16420464 3. Taslim, N. and Saeed Dar, M. 2010. Alcohol Clin Exp Res. [Epub ahead of print]. PMID: 21143250 4. Maloku, E., et al. 2011. Neuropsychopharmacology. 36: 1366-1374. PMID: 21368748
Soluble in DMSO (20 mg/mL), water (6 mg/mL) and ethanol (6 mg/mL)
Store at room temperature
~431.5° C at 760 mmHg (Predicted)
~1.3 g/cm3 (Predicted)
For Research Use Only. Not Intended for Diagnostic or Therapeutic Use.
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Rated 5 out of
Waldburger JM; et alWaldburger JM; et al. (PubMed ID: 18975306) determined that PNU-282,987 caused the production of IL-6 to decrease due to IL-1-stimulated fibroblast-like synoviocytes. -SCBT Publication Review
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