PNU-282987 hydrate CAS: 123464-89-1 (anhydrous)
MF: C14H17ClN2O•HCl
MW: 301.21 (anhydrous basis)
A highly selective AChR α7 agonist.

PNU-282987 hydrate (CAS 123464-89-1 (anhydrous))

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Alternate Names: N-(3R)-1-Azabicyclo[2.2.2]oct-3-yl-4-chloro-benzamide monohydrochloride
Application: A highly selective AChR α7 agonist
CAS Number: 123464-89-1 (anhydrous)
Purity: ≥98%
Molecular Weight: 301.21 (anhydrous basis)
Molecular Formula: C14H17ClN2O•HCl
For Research Use Only. Not Intended for Diagnostic or Therapeutic Use.
* Refer to Certificate of Analysis for lot specific data (including water content).

PNU-282987 hydrate is a highly selective agonist for the homomeric α7 nicotinic acetylcholine receptor (AChR α7). This novel agonist of tAChR α7 has been utilized in multiple model brain investigations of this receptor. Utilizing rat hippocampal slices PNU-282,987 has been reported to evoke whole-cell currents. PNU-282,987 is hypothesized to modulate or enhance GABAergic hippocampal neurotransmission. Additionally, in mouse cerebellum, ethanol-induced ataxia was attenuated in a dose-dependant fashion with administration of PNU-282,987. PNU-282,987 has also been used in various studies to investigate the effects of the compound on hippocampal θ oscillation.


References

1. Hajós, M., et al. 2005. J. Pharmacol. Exp. Ther. 312: 1213-1222. PMID: 15523001
2. Siok, C.J., et al. 2006. Eur. J. Neurosci. 23: 570-574. PMID: 16420464
3. Taslim, N. and Saeed Dar, M. 2010. Alcohol Clin Exp Res. [Epub ahead of print]. PMID: 21143250
4. Maloku, E., et al. 2011. Neuropsychopharmacology. 36: 1366-1374. PMID: 21368748

Physical State :
Solid
Solubility :
Soluble in DMSO (>10 mg/mL).
Storage :
Desiccate at 4° C
Refractive Index :
n20D 1.61
Optical Activity :
α20/D +52.1°, c = 0.95 in chloroform
IC50 :
α3β4 nAChRs: IC50 ≥60 µM
Ki Data :
α7 nAChR: Ki= 26 nM; 5-HT3 receptors: Ki= 930 nM
For Research Use Only. Not Intended for Diagnostic or Therapeutic Use.
WGK Germany :
3
PubChem CID :
16219883
SMILES :
O.Cl.Clc1ccc(cc1)C(=O)N[[email protected]]1CN2CCC1CC2

Download SDS (MSDS)

Certificate of Analysis

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