NS 1738 is a selective AChR α 7 (α7 nAchR) allosteric modulator. α4β2, α3β3 and α1-containing receptors display no substantial activity. In vivo, displays cognitive-enhancing properties. NS 1738 is an activator of AChR α 7.
Timmermann et al (2007) An allosteric modulator of the a7 nicotinic acetylcholine receptor possessing cognition-enhancing properties in vivo. J.Pharmacol.Exp.Ther. 323 294.
Soluble in DMSO (100 mg/ml), and ethanol (100 mM).
Store at 4° C
191.17° C (Predicted)
~344.1° C at 760 mmHg (Predicted)
~1.6 g/cm3 (Predicted)
n20D 1.64 (Predicted)
AChRα7: EC5050 = 3.4 µM (human)
pKa: 8.08 (Predicted), pKb: 0.96 (Predicted)
For Research Use Only. Not Intended for Diagnostic or Therapeutic Use.
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Rated 5 out of
Freitas et alFreitas et al. (PubMed ID 23115222) found that NS 1738 blocked PNU-120596's antinociceptive effects on nicotinic receptors in murine acute and tonic pain models. -SCBT Publication Review
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