Date published: 2025-10-20

1-800-457-3801

SCBT Portrait Logo
Seach Input

NS 1738 (CAS 501684-93-1)

5.0(1)
Write a reviewAsk a question

See product citations (1)

Alternate Names:
N-(5-Chloro-2-hydroxyphenyl)-N′-[2-c hloro-5-(trifluoromethyl)phenyl]urea
Application:
NS 1738 is a selective a7 nAchR allosteric modulator
CAS Number:
501684-93-1
Purity:
≥99%
Molecular Weight:
365.13
Molecular Formula:
C14H9Cl2F3N2O2
For Research Use Only. Not Intended for Diagnostic or Therapeutic Use.
* Refer to Certificate of Analysis for lot specific data.

QUICK LINKS

Selective a7 nAchR allosteric modulator. a4b2, a3b3 and a1-containing receptors display no substantial activity. In vivo, displays cognitive-enhancing properties.


NS 1738 (CAS 501684-93-1) References

  1. Pharmacological characterization of the chronic constriction injury model of neuropathic pain.  |  De Vry, J., et al. 2004. Eur J Pharmacol. 491: 137-48. PMID: 15140630
  2. An allosteric modulator of the alpha7 nicotinic acetylcholine receptor possessing cognition-enhancing properties in vivo.  |  Timmermann, DB., et al. 2007. J Pharmacol Exp Ther. 323: 294-307. PMID: 17625074
  3. Positive allosteric modulation of the alpha7 nicotinic acetylcholine receptor: ligand interactions with distinct binding sites and evidence for a prominent role of the M2-M3 segment.  |  Bertrand, D., et al. 2008. Mol Pharmacol. 74: 1407-16. PMID: 18678621
  4. Comparative pharmacology and computational modelling yield insights into allosteric modulation of human alpha7 nicotinic acetylcholine receptors.  |  Sattelle, DB., et al. 2009. Biochem Pharmacol. 78: 836-43. PMID: 19549506
  5. Competitive binding at a nicotinic receptor transmembrane site of two α7-selective positive allosteric modulators with differing effects on agonist-evoked desensitization.  |  Collins, T., et al. 2011. Neuropharmacology. 61: 1306-13. PMID: 21820451
  6. The antinociceptive effects of nicotinic receptors α7-positive allosteric modulators in murine acute and tonic pain models.  |  Freitas, K., et al. 2013. J Pharmacol Exp Ther. 344: 264-75. PMID: 23115222
  7. Presynaptic α7 nicotinic acetylcholine receptors enhance hippocampal mossy fiber glutamatergic transmission via PKA activation.  |  Cheng, Q. and Yakel, JL. 2014. J Neurosci. 34: 124-33. PMID: 24381273
  8. Alpha7 nicotinic acetylcholine receptor agonists and PAMs as adjunctive treatment in schizophrenia. An experimental study.  |  Marcus, MM., et al. 2016. Eur Neuropsychopharmacol. 26: 1401-1411. PMID: 27474687
  9. Theoretical study of the binding profile of an allosteric modulator NS-1738 with a chimera structure of the α7 nicotinic acetylcholine receptor.  |  Kuang, G., et al. 2016. Phys Chem Chem Phys. 18: 28003-28009. PMID: 27711412
  10. Pharmacological modulation of the α7 nicotinic acetylcholine receptor in a mouse model of mecamylamine-precipitated nicotine withdrawal.  |  Jackson, A., et al. 2018. Psychopharmacology (Berl). 235: 1897-1905. PMID: 29549391
  11. Quantitative assessment of oligomeric amyloid β peptide binding to α7 nicotinic receptor.  |  Cecon, E., et al. 2019. Br J Pharmacol. 176: 3475-3488. PMID: 30981214
  12. Functional α7 nicotinic acetylcholine receptors in GABAergic neurons of the interpeduncular nucleus.  |  Jin, XT. and Drenan, RM. 2022. Neuropharmacology. 208: 108987. PMID: 35167902

Ordering Information

Product NameCatalog #UNITPriceQtyFAVORITES

NS 1738, 10 mg

sc-204136
10 mg
$149.00

NS 1738, 50 mg

sc-204136A
50 mg
$620.00