NS 1738 CAS: 501684-93-1
MF: C14H9Cl2F3N2O2
MW: 365.13
A selective a7 nAchR allosteric modulator.

NS 1738 (CAS 501684-93-1)

NS 1738 | CAS 501684-93-1 is rated 5.0 out of 5 by 1.
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Alternate Names: N-(5-Chloro-2-hydroxyphenyl)-N'-[2-c hloro-5-(trifluoromethyl)phenyl]urea
Application: NS 1738 is a selective a7 nAchR allosteric modulator
CAS Number: 501684-93-1
Purity: ≥99%
Molecular Weight: 365.13
Molecular Formula: C14H9Cl2F3N2O2
For Research Use Only. Not Intended for Diagnostic or Therapeutic Use.
* Refer to Certificate of Analysis for lot specific data (including water content).

NS 1738 is a selective AChR α 7 (α7 nAchR) allosteric modulator. α4β2, α3β3 and α1-containing receptors display no substantial activity. In vivo, displays cognitive-enhancing properties. NS 1738 is an activator of AChR α 7.


References

Timmermann et al (2007) An allosteric modulator of the a7 nicotinic acetylcholine receptor possessing cognition-enhancing properties in vivo. J.Pharmacol.Exp.Ther. 323 294.

Appearance :
Powder
Physical State :
Solid
Solubility :
Soluble in DMSO (100 mg/ml), and ethanol (100 mM).
Storage :
Store at 4° C
Melting Point :
191.17° C (Predicted)
Boiling Point :
~344.1° C at 760 mmHg (Predicted)
Density :
~1.6 g/cm3 (Predicted)
Refractive Index :
n20D 1.64 (Predicted)
IC50 :
AChRα7: EC5050 = 3.4 µM (human)
pK Values :
pKa: 8.08 (Predicted), pKb: 0.96 (Predicted)
For Research Use Only. Not Intended for Diagnostic or Therapeutic Use.
RTECS :
YS5560000
PubChem CID :
310378
MDL Number :
MFCD11100189
SMILES :
C1=CC(=C(C=C1C(F)(F)F)NC(=O)NC2=C(C=CC(=C2)Cl)O)Cl

Download SDS (MSDS)

Certificate of Analysis

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Rated 5 out of 5 by from Freitas et al Freitas et al. (PubMed ID 23115222) found that NS 1738 blocked PNU-120596's antinociceptive effects on nicotinic receptors in murine acute and tonic pain models. -SCBT Publication Review
Date published: 2015-02-19
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