ACF Activators
ACF activators exert their influence through various biochemical pathways, ensuring the protein's effective participation in chromatin assembly and remodeling. For instance, certain small molecules elevate intracellular levels of secondary messengers, which in turn activate protein kinases. These kinases can phosphorylate ACF, thereby enhancing its activity in organizing nucleosomes, an essential step for DNA replication and repair. On the other hand, specific inhibitors target enzymes responsible for tightening chromatin structure by removing acetyl groups from histones. Inhibition of these enzymes results in a more relaxed chromatin state, which is conducive to the actions of ACF, allowing it to more easily navigate and assemble nucleosomes.
Moreover, the function of ACF is indirectly supported by compounds that modulate the epigenetic landscape. Some agents, by integrating into the genetic material, induce hypomethylation, thereby creating a more accessible chromatin configuration for ACF-mediated assembly processes. Others act by inhibiting proteasome activity, leading to the accumulation of proteins that aid in the stability and activity of ACF. Additionally, small molecules that interfere with DNA structure can indirectly necessitate an increased activity of chromatin assembly factors to maintain genomic integrity.
Items 1 to 10 of 12 total
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| Product Name | CAS # | Catalog # | QUANTITY | Price | Citations | RATING |
|---|---|---|---|---|---|---|
Forskolin | 66575-29-9 | sc-3562 sc-3562A sc-3562B sc-3562C sc-3562D | 5 mg 50 mg 1 g 2 g 5 g | $76.00 $150.00 $725.00 $1385.00 $2050.00 | 73 | |
Enhances intracellular cAMP levels, which can lead to phosphorylation and activation of PKA. PKA can phosphorylate ACF, increasing its activity in chromatin remodeling. | ||||||
Trichostatin A | 58880-19-6 | sc-3511 sc-3511A sc-3511B sc-3511C sc-3511D | 1 mg 5 mg 10 mg 25 mg 50 mg | $149.00 $470.00 $620.00 $1199.00 $2090.00 | 33 | |
Inhibits histone deacetylase, resulting in hyperacetylation of histones. This open chromatin state can facilitate the action of ACF in nucleosome assembly. | ||||||
5-Azacytidine | 320-67-2 | sc-221003 | 500 mg | $280.00 | 4 | |
Incorporation into DNA results in hypomethylation of genomic DNA, which may assist ACF function by allowing easier access to chromatin for assembly. | ||||||
Caffeine | 58-08-2 | sc-202514 sc-202514A sc-202514B sc-202514C sc-202514D | 5 g 100 g 250 g 1 kg 5 kg | $32.00 $66.00 $95.00 $188.00 $760.00 | 13 | |
Acts as a phosphodiesterase inhibitor, thereby preventing the degradation of cAMP and enhancing PKA activity, which can indirectly increase ACF activity. | ||||||
Nicotinamide | 98-92-0 | sc-208096 sc-208096A sc-208096B sc-208096C | 100 g 250 g 1 kg 5 kg | $43.00 $65.00 $200.00 $815.00 | 6 | |
Serves as an inhibitor of sirtuins, a class of NAD+-dependent deacetylases. Inhibition of sirtuins can lead to an open chromatin structure aiding ACF function. | ||||||
MG-132 [Z-Leu- Leu-Leu-CHO] | 133407-82-6 | sc-201270 sc-201270A sc-201270B | 5 mg 25 mg 100 mg | $56.00 $260.00 $980.00 | 163 | |
Proteasome inhibitor that can lead to upregulation of heat shock proteins, which can stabilize proteins like ACF and enhance its chromatin assembly activity. | ||||||
β-Estradiol | 50-28-2 | sc-204431 sc-204431A | 500 mg 5 g | $62.00 $178.00 | 8 | |
It can modulate chromatin structure through its receptors, potentially enhancing the activity of chromatin assembly factors such as ACF. | ||||||
Sodium Butyrate | 156-54-7 | sc-202341 sc-202341B sc-202341A sc-202341C | 250 mg 5 g 25 g 500 g | $30.00 $46.00 $82.00 $218.00 | 19 | |
Inhibitor of histone deacetylases, which increases histone acetylation and may facilitate the chromatin remodeling activity of ACF. | ||||||
Methotrexate | 59-05-2 | sc-3507 sc-3507A | 100 mg 500 mg | $92.00 $209.00 | 33 | |
Antimetabolite that can cause DNA damage and repair mechanisms that may involve chromatin remodeling, potentially increasing the demand for ACF activity. | ||||||
Chloroquine | 54-05-7 | sc-507304 | 250 mg | $68.00 | 2 | |
Known to intercalate into DNA and alter its structure, which may indirectly enhance the chromatin remodeling activity of ATP-dependent factors like ACF. | ||||||