ACF Inhibitors
Inhibitors that target the ATP-dependent chromatin assembly factor large subunit (ACF) are crucial in modulating its role in nucleosome assembly and chromatin remodeling. Compounds that alter the post-translational modification of histones, such as histone deacetylase inhibitors, increase histone acetylation, resulting in a more relaxed chromatin state that reduces ACF's ability to interact with chromatin and assemble nucleosomes effectively. Similarly, inhibitors that affect DNA methylation patterns and DNA-binding properties, such as DNA methyltransferase and G-C rich sequence-binding inhibitors, can impede the recruitment and subsequent activity of ACF at specific genomic loci. This disruption in the chromatin landscape can lead to a diminished demand for ACF's chromatin assembly services.
Moreover, the regulation of ACF's function extends to the influence of cellular processes and the availability of related chromatin-modifying factors. Proteasome inhibitors, microtubule-disrupting agents, and kinase inhibitors that modulate transcription factor activity and cell cycle progression can indirectly affect the chromatin assembly function of ACF. These inhibitors can lead to an accumulation of polyubiquitinated proteins and changes in cell dynamics, which may in turn reduce the need for chromatin remodeling by ACF. Inhibitors of RNA polymerase II, bromodomain proteins, and histone acetyltransferases also contribute to the reduced functional activity of ACF by decreasing the demand for nucleosome assembly in response to transcriptional changes and by altering the epigenetic marks that guide the chromatin remodeling process.
Items 1 to 10 of 12 total
Display:
| Product Name | CAS # | Catalog # | QUANTITY | Price | Citations | RATING |
|---|---|---|---|---|---|---|
Trichostatin A | 58880-19-6 | sc-3511 sc-3511A sc-3511B sc-3511C sc-3511D | 1 mg 5 mg 10 mg 25 mg 50 mg | $149.00 $470.00 $620.00 $1199.00 $2090.00 | 33 | |
Trichostatin A is a histone deacetylase inhibitor that increases the acetylation of histones, leading to a more relaxed chromatin structure. This can indirectly inhibit ACF by reducing its ability to bind to chromatin and assemble nucleosomes on deacetylated histones. | ||||||
Chloroquine | 54-05-7 | sc-507304 | 250 mg | $68.00 | 2 | |
Chloroquine interferes with lysosomal acidification, which can affect the post-translational modification of histones. This might indirectly inhibit ACF by disrupting the normal histone code that ACF relies on for chromatin assembly and remodeling activities. | ||||||
5-Azacytidine | 320-67-2 | sc-221003 | 500 mg | $280.00 | 4 | |
5-Azacytidine is an inhibitor of DNA methyltransferases. By altering DNA methylation patterns, it can affect the recruitment of ACF to specific genomic locations, thus inhibiting its chromatin assembly function. | ||||||
Mithramycin A | 18378-89-7 | sc-200909 | 1 mg | $54.00 | 6 | |
Mithramycin A binds to G-C rich DNA sequences and prevents transcription factor binding, which could indirectly inhibit ACF by altering the chromatin landscape and its subsequent assembly activity. | ||||||
MG-132 [Z-Leu- Leu-Leu-CHO] | 133407-82-6 | sc-201270 sc-201270A sc-201270B | 5 mg 25 mg 100 mg | $56.00 $260.00 $980.00 | 163 | |
MG-132 is a proteasome inhibitor that can lead to increased levels of polyubiquitinated proteins. This can indirectly affect ACF function by disrupting the protein degradation pathways that regulate the availability of factors necessary for chromatin assembly. | ||||||
Nocodazole | 31430-18-9 | sc-3518B sc-3518 sc-3518C sc-3518A | 5 mg 10 mg 25 mg 50 mg | $58.00 $83.00 $140.00 $242.00 | 38 | |
Nocodazole disrupts microtubule polymerization and can indirectly affect ACF by altering cell cycle progression, during which chromatin remodeling is crucial. | ||||||
DRB | 53-85-0 | sc-200581 sc-200581A sc-200581B sc-200581C | 10 mg 50 mg 100 mg 250 mg | $42.00 $185.00 $310.00 $650.00 | 6 | |
DRB is a kinase inhibitor that can inhibit RNA Polymerase II phosphorylation, affecting transcription elongation. This could indirectly inhibit ACF by reducing the chromatin remodeling requirements associated with active transcription. | ||||||
α-Amanitin | 23109-05-9 | sc-202440 sc-202440A | 1 mg 5 mg | $260.00 $1029.00 | 26 | |
α-Amanitin inhibits eukaryotic RNA polymerase II, potentially reducing the demand for chromatin remodeling by ACF during transcription. | ||||||
Sodium Butyrate | 156-54-7 | sc-202341 sc-202341B sc-202341A sc-202341C | 250 mg 5 g 25 g 500 g | $30.00 $46.00 $82.00 $218.00 | 19 | |
Sodium Butyrate acts as a histone deacetylase inhibitor, promoting a chromatin state that is less reliant on ACF-mediated nucleosome assembly due to increased histone acetylation. | ||||||
BIX01294 hydrochloride | 1392399-03-9 | sc-293525 sc-293525A sc-293525B | 1 mg 5 mg 25 mg | $36.00 $110.00 $400.00 | ||
An inhibitor of G9a histone methyltransferase, altering histone methylation marks. This could indirectly inhibit ACF by changing the epigenetic landscape, affecting its recruitment and assembly activity. | ||||||