ABT1 Activators
ABT1 Activators are chemical compounds that enhance the functional activity of ABT1, a protein involved in the regulation of gene expression. These activators primarily function by modulating the post-translational modifications of ABT1 or activating the signaling pathways in which ABT1 is involved. The chosen ABT1 Activators include ATP, which enhances ABT1's ATPase activity by providing a higher substrate availability. Farnesyl pyrophosphate enhances ABT1's activity by facilitating its farnesylation, a post-translational modification crucial for the localization of ABT1 to the plasma membrane where it can interact with downstream signaling partners.
Other ABT1 activators, such as Sodium orthovanadate, Okadaic acid, and Calyculin A, function by inhibiting protein phosphatases, thereby enhancing the phosphorylation status of ABT1, which is crucial for its activation. Similarly, Phorbol 12-myristate 13-acetate (PMA) and Forskolin can enhance the activity of ABT1 by activating protein kinases that can phosphorylate and activate ABT1. MG-132 is another ABT1 activator that prevents the degradation of phosphorylated proteins, thereby enhancing the activity of ABT1. EGF and Insulin are growth factors that activate downstream signaling pathways, leading to the activation of ABT1. PD98059, a specific inhibitor of MEK1, enhances the activation of ABT1 by suppressing the activation of ERK1/2. It is important to note that all these activators enhance the functional activity of ABT1 by specifically targeting the signaling pathways or biological processes in which ABT1 is directly involved, and not by enhancing its transcription or translation.
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| Product Name | CAS # | Catalog # | QUANTITY | Price | Citations | RATING |
|---|---|---|---|---|---|---|
Adenosine 5′-Triphosphate, disodium salt | 987-65-5 | sc-202040 sc-202040A | 1 g 5 g | $39.00 $75.00 | 9 | |
ATP is the direct substrate for ABT1's ATPase activity. An increase in ATP concentration can enhance ABT1's activity by providing a higher substrate availability. | ||||||
Sodium Orthovanadate | 13721-39-6 | sc-3540 sc-3540B sc-3540A | 5 g 10 g 50 g | $49.00 $57.00 $187.00 | 142 | |
Sodium orthovanadate is a potent inhibitor of tyrosine phosphatases. By inhibiting tyrosine phosphatases, it can enhance the phosphorylation status of ABT1, leading to its activation. | ||||||
Okadaic Acid | 78111-17-8 | sc-3513 sc-3513A sc-3513B | 25 µg 100 µg 1 mg | $291.00 $530.00 $1800.00 | 78 | |
Okadaic acid is a potent inhibitor of protein phosphatases 1 and 2A. By inhibiting these phosphatases, it can enhance the phosphorylation status of ABT1, leading to its activation. | ||||||
PMA | 16561-29-8 | sc-3576 sc-3576A sc-3576B sc-3576C sc-3576D | 1 mg 5 mg 10 mg 25 mg 100 mg | $41.00 $132.00 $214.00 $500.00 $948.00 | 119 | |
PMA is a potent activator of protein kinase C (PKC). PKC can phosphorylate and activate ABT1, thus PMA can indirectly enhance the activity of ABT1. | ||||||
Calyculin A | 101932-71-2 | sc-24000 sc-24000A | 10 µg 100 µg | $163.00 $800.00 | 59 | |
Calyculin A is a potent inhibitor of protein phosphatases 1 and 2A. By inhibiting these phosphatases, it can enhance the phosphorylation status of ABT1, leading to its activation. | ||||||
Forskolin | 66575-29-9 | sc-3562 sc-3562A sc-3562B sc-3562C sc-3562D | 5 mg 50 mg 1 g 2 g 5 g | $78.00 $153.00 $740.00 $1413.00 $2091.00 | 73 | |
Forskolin is an activator of adenylate cyclase, which can increase the levels of cyclic AMP (cAMP). Elevated cAMP levels can activate protein kinase A (PKA), which can phosphorylate and activate ABT1. | ||||||
8-Bromo-cAMP | 76939-46-3 | sc-201564 sc-201564A | 10 mg 50 mg | $126.00 $328.00 | 30 | |
8-Bromo-cAMP is a cell-permeable cAMP analog that can activate PKA. PKA can phosphorylate and activate ABT1. | ||||||
MG-132 [Z-Leu- Leu-Leu-CHO] | 133407-82-6 | sc-201270 sc-201270A sc-201270B | 5 mg 25 mg 100 mg | $60.00 $265.00 $1000.00 | 163 | |
MG-132 is a proteasome inhibitor that can prevent the degradation of phosphorylated proteins. By preventing the degradation of phosphorylated ABT1, MG-132 can enhance the activity of ABT1. | ||||||
Insulin | 11061-68-0 | sc-29062 sc-29062A sc-29062B | 100 mg 1 g 10 g | $156.00 $1248.00 $12508.00 | 82 | |
Insulin activates the insulin receptor, leading to activation of the PI3K/AKT pathway. ABT1 is a known downstream effector of this pathway, so activation of this pathway can enhance the activity of ABT1. | ||||||
PD 98059 | 167869-21-8 | sc-3532 sc-3532A | 1 mg 5 mg | $40.00 $92.00 | 212 | |
PD98059 is a specific inhibitor of MEK1, which can suppress the activation of ERK1/2. ABT1 has been shown to be activated by ERK1/2, so inhibition of ERK1/2 activation by PD98059 can enhance the activation of ABT1. | ||||||