ABHD2 Activators
ABHD2 activators pertain to a class of chemicals that target the enzyme alpha/beta hydrolase domain-containing 2 (ABHD2). This enzyme belongs to a larger family of hydrolases, which are characterized by their ability to catalyze the hydrolysis of various chemical bonds, typically involving the cleavage of ester, ether, or amide linkages. ABHD2 is distinct in its structure and function, possessing a unique active site that allows it to engage with specific substrates. The activators of ABHD2 are molecules that enhance the enzyme's intrinsic catalytic activity. This is achieved through a number of potential mechanisms, such as increasing substrate affinity, stabilizing the enzyme in an active conformation, or facilitating the proper orientation of substrate and catalytic residues within the active site. These activators are usually small molecules that can bind to the enzyme, altering its dynamics and function.
The regulatory role of ABHD2 in various biochemical pathways underscores the significance of its modulators. ABHD2 activators, by modulating the enzyme's activity, can influence the rate at which ABHD2 processes its substrates. This adjustment of enzymatic function is achieved without the destruction or denaturation of the target enzyme, which is a key aspect of their mode of action. The design of such activators involves a deep understanding of the enzyme's structure, the dynamics of its active site, and the nature of its interaction with potential substrates and co-factors. Advances in computational chemistry, along with crystallography and other structural determination methods, have enabled researchers to better visualize ABHD2 at the molecular level, thus facilitating the rational design of its activators. The development of these activators often requires iterative cycles of synthesis and testing to optimize their efficacy in modulating the enzyme's activity.
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| Product Name | CAS # | Catalog # | QUANTITY | Price | Citations | RATING |
|---|---|---|---|---|---|---|
Forskolin | 66575-29-9 | sc-3562 sc-3562A sc-3562B sc-3562C sc-3562D | 5 mg 50 mg 1 g 2 g 5 g | $76.00 $150.00 $725.00 $1385.00 $2050.00 | 73 | |
Forskolin activates adenylyl cyclase, leading to increased levels of cyclic AMP (cAMP) in cells. Elevated cAMP activates protein kinase A (PKA), which can phosphorylate target proteins, potentially enhancing the lipase activity of ABHD2. | ||||||
PMA | 16561-29-8 | sc-3576 sc-3576A sc-3576B sc-3576C sc-3576D | 1 mg 5 mg 10 mg 25 mg 100 mg | $40.00 $129.00 $210.00 $490.00 $929.00 | 119 | |
PMA is a potent activator of protein kinase C (PKC), which can phosphorylate a variety of proteins. PKC-mediated phosphorylation may increase ABHD2 activity by altering its interaction with membranes or substrates. | ||||||
D-erythro-Sphingosine-1-phosphate | 26993-30-6 | sc-201383 sc-201383D sc-201383A sc-201383B sc-201383C | 1 mg 2 mg 5 mg 10 mg 25 mg | $162.00 $316.00 $559.00 $889.00 $1693.00 | 7 | |
S1P interacts with its G protein-coupled receptors, triggering downstream signaling that can lead to the activation of PKC and other kinases, potentially influencing the activity of ABHD2 by altering its phosphorylation state. | ||||||
Ionomycin | 56092-82-1 | sc-3592 sc-3592A | 1 mg 5 mg | $76.00 $265.00 | 80 | |
Ionomycin is a calcium ionophore that increases intracellular calcium levels, which can activate calcium-dependent protein kinases and phosphatases, potentially modulating the activity of ABHD2 through phosphorylation or dephosphorylation. | ||||||
Arachidonic Acid (20:4, n-6) | 506-32-1 | sc-200770 sc-200770A sc-200770B | 100 mg 1 g 25 g | $90.00 $235.00 $4243.00 | 9 | |
Arachidonic acid can be a substrate for ABHD2, and thus its availability can directly influence ABHD2's enzymatic activity. It can also be metabolized into eicosanoids, which may further modulate ABHD2 activity indirectly through signaling pathways. | ||||||
A23187 | 52665-69-7 | sc-3591 sc-3591B sc-3591A sc-3591C | 1 mg 5 mg 10 mg 25 mg | $54.00 $128.00 $199.00 $311.00 | 23 | |
A23187 is a calcium ionophore like ionomycin, and it can similarly increase intracellular calcium levels to activate calcium-dependent kinases that may modulate ABHD2 activity. | ||||||
Retinoic Acid, all trans | 302-79-4 | sc-200898 sc-200898A sc-200898B sc-200898C | 500 mg 5 g 10 g 100 g | $65.00 $319.00 $575.00 $998.00 | 28 | |
Retinoic acid can modulate gene expression through its nuclear receptors. It could lead to changes in the expression of proteins that interact with ABHD2 or proteins that modulate its activity, thereby indirectly enhancing ABHD2 activity. | ||||||
Oleylethanolamide | 111-58-0 | sc-201400 sc-201400A | 10 mg 50 mg | $88.00 $190.00 | 1 | |
OEA is a natural ligand for peroxisome proliferator-activated receptor-alpha (PPAR-alpha). Activation of PPAR-alpha can lead to altered expression of proteins that may interact with or regulate ABHD2, enhancing its activity. | ||||||
Lysophosphatidic Acid | 325465-93-8 | sc-201053 sc-201053A | 5 mg 25 mg | $96.00 $334.00 | 50 | |
LPA acts on its G protein-coupled receptors leading to activation of various kinases. These kinases could phosphorylate ABHD2 or alter its localization, thus potentially enhancing its activity. | ||||||
IBMX | 28822-58-4 | sc-201188 sc-201188B sc-201188A | 200 mg 500 mg 1 g | $159.00 $315.00 $598.00 | 34 | |
IBMX is a non-selective inhibitor of phosphodiesterases, which prevents the breakdown of cAMP and cGMP, leading to their accumulation. The increased levels of these cyclic nucleotides can activate PKA, potentially enhancing the activity of ABHD2. | ||||||