ABCD2 Activators
ABCD2 Activators belong to a class of chemical compounds that are primarily known for their ability to modulate the activity of the ABCD2 protein, which plays a pivotal role in cellular processes. These activators are characterized by their distinct chemical structures and mechanisms of action, which enable them to interact with the ABCD2 protein and influence its function. The term "ABCD2" refers to a specific gene that encodes a membrane-associated protein involved in the transport of fatty acids into peroxisomes, cellular organelles responsible for lipid metabolism. ABCD2, also known as ALDP (Adrenoleukodystrophy Protein), belongs to the family of ATP-binding cassette (ABC) transporters, which are integral membrane proteins involved in the transportation of various substrates across cellular membranes.
ABCD2 activators are designed to bind to the ABCD2 protein, leading to conformational changes that enhance its transport activity. This activation results in the improved import of fatty acids into peroxisomes, ultimately impacting lipid metabolism and related cellular processes. The chemical structures of ABCD2 activators vary, but they typically possess functional groups that interact with specific regions of the ABCD2 protein, stabilizing its active conformation. By doing so, ABCD2 activators can influence lipid homeostasis, which is crucial for various cellular functions, including myelin sheath maintenance, energy production, and detoxification processes. These activators are essential tools in research aimed at understanding the biology of ABCD2 and its role in cellular physiology.
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| Product Name | CAS # | Catalog # | QUANTITY | Price | Citations | RATING |
|---|---|---|---|---|---|---|
Curcumin | 458-37-7 | sc-200509 sc-200509A sc-200509B sc-200509C sc-200509D sc-200509F sc-200509E | 1 g 5 g 25 g 100 g 250 g 1 kg 2.5 kg | $36.00 $68.00 $107.00 $214.00 $234.00 $862.00 $1968.00 | 47 | |
Tetrahydrocurcumin, a derivative of curcumin found in turmeric, has been suggested to activate ABCD2 by enhancing its expression or function. | ||||||
Resveratrol | 501-36-0 | sc-200808 sc-200808A sc-200808B | 100 mg 500 mg 5 g | $60.00 $185.00 $365.00 | 64 | |
Resveratrol, a natural polyphenol found in red wine, grapes, and berries, is known for its potential to activate ABCD2. | ||||||
Fenofibrate | 49562-28-9 | sc-204751 | 5 g | $40.00 | 9 | |
Fenofibrate is used to lower cholesterol levels, can activate ABCD2. It likely works by modulating lipid metabolism and peroxisome proliferator-activated receptor alpha (PPARα) signaling, which indirectly affects ABCD2 expression. | ||||||
Bezafibrate | 41859-67-0 | sc-204650B sc-204650 sc-204650A sc-204650C | 500 mg 1 g 5 g 10 g | $30.00 $45.00 $120.00 $200.00 | 5 | |
Similar to fenofibrate lowers cholesterol and triglyceride levels. It activates ABCD2 through PPARα signaling, which leads to increased ABCD2 expression and function. | ||||||
Gemfibrozil | 25812-30-0 | sc-204764 sc-204764A | 5 g 25 g | $65.00 $262.00 | 2 | |
Gemfibrozil activates ABCD2 via the PPARα pathway. This activation enhances the transport of lipids and fatty acids by ABCD2. | ||||||
WY 14643 | 50892-23-4 | sc-203314 | 50 mg | $133.00 | 7 | |
WY-14,643 is a synthetic compound often used in research to activate PPARα, indirectly influencing ABCD2 expression. PPARα activation leads to changes in gene expression, including that of ABCD2. | ||||||
Clofibrate | 637-07-0 | sc-200721 | 1 g | $32.00 | ||
Clofibrate activates ABCD2 by stimulating PPARα, which in turn promotes the expression and activity of ABCD2. | ||||||
Ciprofibrate | 52214-84-3 | sc-204689 sc-204689A | 25 mg 100 mg | $57.00 $169.00 | ||
Ciprofibrate is used for lipid disorders, activates ABCD2 through the PPARα pathway. | ||||||
Avasimibe | 166518-60-1 | sc-364315 sc-364315A sc-364315B sc-364315C | 10 mg 50 mg 500 mg 1 g | $107.00 $413.00 $2040.00 $3060.00 | 1 | |
Avasimibe inhibits ACAT (acyl-CoA cholesterol acyltransferase) and has been reported to increase ABCD2 expression. By blocking ACAT, it indirectly affects cholesterol metabolism and ABCD2 activity. | ||||||
Rosiglitazone | 122320-73-4 | sc-202795 sc-202795A sc-202795C sc-202795D sc-202795B | 25 mg 100 mg 500 mg 1 g 5 g | $118.00 $320.00 $622.00 $928.00 $1234.00 | 38 | |
Rosiglitazone activates PPARγ, which can indirectly influence ABCD2 activation. PPARγ activation may lead to changes in gene expression, including that of ABCD2. | ||||||