Date published: 2026-5-18

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ABCD2 Inhibitors

ABCD2 inhibitors belong to a distinct chemical class characterized by their ability to modulate the activity of the ABCD2 protein. These inhibitors are designed to interact with the specific binding sites or active regions of the ABCD2 protein, which plays a crucial role in certain biological processes. The structural framework of ABCD2 inhibitors typically consists of a combination of diverse chemical moieties, allowing for targeted interactions with the protein's functional domains. These inhibitors are designed using computational modeling, structure-activity relationship studies, and medicinal chemistry approaches to ensure their specificity and potency.

The development of ABCD2 inhibitors involves iterative optimization of their chemical structures to enhance their binding affinity and selectivity for the ABCD2 protein. Through intricate modifications, scientists aim to create inhibitors that can effectively hinder the ABCD2 protein's activity by competitively binding to its active sites. The study and synthesis of ABCD2 inhibitors contribute to a deeper understanding of the protein's role in cellular pathways and offer avenues for further research in the field of molecular modulation.

SEE ALSO...

Product NameCAS #Catalog #QUANTITYPriceCitationsRATING

Verapamil

52-53-9sc-507373
1 g
$374.00
(0)

Inhibits ABCB1 (P-glycoprotein) by binding to it and preventing efflux of substrates, increasing drug levels in cells.

Cyclosporin A

59865-13-3sc-3503
sc-3503-CW
sc-3503A
sc-3503B
sc-3503C
sc-3503D
100 mg
100 mg
500 mg
10 g
25 g
100 g
$63.00
$92.00
$250.00
$485.00
$1035.00
$2141.00
69
(5)

Binds to ABCB1 and modifies its conformation, blocking its efflux function and increasing drug intracellular concentrations.

Quinidine

56-54-2sc-212614
10 g
$104.00
3
(1)

Inhibits ABCB1 by competing for its drug-binding sites, effectively blocking the transport of substrates.

Elacridar

143664-11-3sc-207613A
sc-207613
sc-207613B
sc-207613C
sc-207613D
5 mg
10 mg
50 mg
100 mg
1 g
$98.00
$113.00
$411.00
$525.00
$2606.00
19
(1)

Potent inhibitor of ABCB1, preventing drug efflux and enhancing the intracellular accumulation of substrates.

Ko 143

461054-93-3sc-204030
sc-204030A
1 mg
10 mg
$109.00
$261.00
21
(1)

Highly specific inhibitor of ABCG2, blocking its efflux function and increasing the sensitivity of cancer cells to chemotherapy.

Fumitremorgin C

118974-02-0sc-202162
250 µg
$408.00
5
(1)

Inhibits ABCG2 by binding to its substrate-binding site, reducing the efflux of anticancer drugs and enhancing their effects.

Lapatinib

231277-92-2sc-353658
100 mg
$420.00
32
(1)

Acts as an inhibitor of ABCG2, increasing the oral bioavailability and brain penetration of certain chemotherapeutic agents.

Erlotinib, Free Base

183321-74-6sc-396113
sc-396113A
sc-396113B
sc-396113C
sc-396113D
500 mg
1 g
5 g
10 g
100 g
$87.00
$135.00
$293.00
$505.00
$3827.00
42
(0)

Inhibits ABCG2 and other transporters, improving the oral bioavailability of co-administered drugs.