Molecular structure of Fumitremorgin C, CAS Number: 118974-02-0
Fumitremorgin C (CAS 118974-02-0)
See product citations (5)
Application:
Fumitremorgin C is a strong and specific BRCP inhibitor
CAS Number:
118974-02-0
Purity:
>95%
Molecular Weight:
379.5
Molecular Formula:
C22H25N3O3
For Research Use Only. Not Intended for Diagnostic or Therapeutic Use.
* Refer to Certificate of Analysis for lot specific data.
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SDS & Certificate of Analysis
Fumitremorgin C (FTC) is a diketopiperazine, fungal toxin, that acts as a strong and specific ABCG2/BRCP (ATP-binding cassette G2/breast cancer resistance protein) inhibitor. Studies indicate that Fumitremorgin C inhibits cell cycle progression in the M phase of tsFT210 mouse cells. Isolated from Aspergillus fumigatus, Fumitremorgin C has been proved to revert resistance to topotecan, mitoxanthrone, doxorubicin, in S1-M1–3.2 cells that over express BRCP/ABCG2 mRNA. Reports suggest that Fumitremorgin C inhibits BRCP/ABCG2-mediated transport, which results in the re-sensitization of drug-resistant cells. Fumitremorgin Cs neurotoxicity has lead researchers to investigate analogues of Fumitremorgin C, such as Ko143.
Fumitremorgin C (CAS 118974-02-0) References
- Fumitremorgin C reverses multidrug resistance in cells transfected with the breast cancer resistance protein. | Rabindran, SK., et al. 2000. Cancer Res. 60: 47-50. PMID: 10646850
- Potent and specific inhibition of the breast cancer resistance protein multidrug transporter in vitro and in mouse intestine by a novel analogue of fumitremorgin C. | Allen, JD., et al. 2002. Mol Cancer Ther. 1: 417-25. PMID: 12477054
- Curcumin Improves the Tumoricidal Effect of Mitomycin C by Suppressing ABCG2 Expression in Stem Cell-Like Breast Cancer Cells. | Zhou, Q., et al. 2015. PLoS One. 10: e0136694. PMID: 26305906
- Effect of ABCG2/BCRP Expression on Efflux and Uptake of Gefitinib in NSCLC Cell Lines. | Galetti, M., et al. 2015. PLoS One. 10: e0141795. PMID: 26536031
- Drug Resistance of Endocardial Endothelial Cells is Related to Higher Endogenous ABCG2. | Ajithkumar, GS., et al. 2016. Cardiovasc Toxicol. 16: 390-405. PMID: 26661076
- The ABCG2 Efflux Transporter in the Mammary Gland Mediates Veterinary Drug Secretion across the Blood-Milk Barrier into Milk of Dairy Cows. | Mahnke, H., et al. 2016. Drug Metab Dispos. 44: 700-8. PMID: 26956640
- Combining ABCG2 Inhibitors with IMMU-132, an Anti-Trop-2 Antibody Conjugate of SN-38, Overcomes Resistance to SN-38 in Breast and Gastric Cancers. | Chang, CH., et al. 2016. Mol Cancer Ther. 15: 1910-9. PMID: 27207776
- Synthesis and Investigation of Tetrahydro-β-carboline Derivatives as Inhibitors of the Breast Cancer Resistance Protein (ABCG2). | Spindler, A., et al. 2016. J Med Chem. 59: 6121-35. PMID: 27280693
- Assessment of ABCG2-mediated transport of pesticides across the rabbit placenta barrier using a novel MDCKII in vitro model. | Halwachs, S., et al. 2016. Toxicol Appl Pharmacol. 305: 66-74. PMID: 27288731
- Cytotoxic activity of Secondary Metabolites from Marine-derived Fungus Neosartorya siamensis in Human Cancer Cells. | Prata-Sena, M., et al. 2016. Phytother Res. 30: 1862-1871. PMID: 27530464
- Chevalone C analogues and globoscinic acid derivatives from the fungus Neosartorya spinosa KKU-1NK1. | Rajachan, OA., et al. 2016. Phytochemistry. 132: 68-75. PMID: 27680770
- Biosynthetic approaches to creating bioactive fungal metabolites: Pathway engineering and activation of secondary metabolism. | Motoyama, T. and Osada, H. 2016. Bioorg Med Chem Lett. 26: 5843-5850. PMID: 27865702
- Antituberculosis compounds from a deep-sea-derived fungus Aspergillus sp. SCSIO Ind09F01. | Luo, X., et al. 2017. Nat Prod Res. 31: 1958-1962. PMID: 28068839
- rtfA controls development, secondary metabolism, and virulence in Aspergillus fumigatus. | Myers, RR., et al. 2017. PLoS One. 12: e0176702. PMID: 28453536
- Novel mammalian cell cycle inhibitors, tryprostatins A, B and other diketopiperazines produced by Aspergillus fumigatus. I. Taxonomy, fermentation, isolation and biological properties. | Cui, CB., et al. 1996. J Antibiot (Tokyo). 49: 527-33. PMID: 8698634
Inhibitor of:
4933427G17Rik, ABCB6, ABCC11, ABCD2, ABCF3, ABCG2, Amino acid-binding ABC transporter, and ATPase.Activator of:
MetAP-1, and MRP6.Ordering Information
| Product Name | Catalog # | UNIT | Price | Qty | FAVORITES | |
Fumitremorgin C, 250 µg | sc-202162 | 250 µg | $408.00 |