Molecular structure of Ciprofibrate, CAS Number: 52214-84-3
Ciprofibrate (CAS 52214-84-3)
Alternate Names:
2-[4-(2,2-Dichlorocyclopropyl)phenoxy]-2-methylpropanoic acid
Application:
Ciprofibrate is a hypolipidemic agonist of PPARα
CAS Number:
52214-84-3
Purity:
≥98%
Molecular Weight:
289.2
Molecular Formula:
C13H14Cl2O3
For Research Use Only. Not Intended for Diagnostic or Therapeutic Use.
* Refer to Certificate of Analysis for lot specific data.
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SDS & Certificate of Analysis
Ciprofibrate is a hypolipidemic compound that can induce proliferation of peroxisomes in liver cells of rats. Known to be a PPARα (peroxisome proliferator-activated receptor α) agonist.
Ciprofibrate (CAS 52214-84-3) References
Comparison of the effects of various peroxisome proliferators on peroxisomal enzyme activities, DNA synthesis, and apoptosis in rat and human hepatocyte cultures: V. Goll, et al.; Toxicol. Appl. Pharmacol. 160, 21 (1999) Phosphorylation of peroxisome proliferator-activated receptor alpha in rat Fao cells and stimulation by ciprofibrate: P. Passilly, et al.; Biochem. Pharmacol. 58, 1001 (1999) Differences in cell proliferation in rodent and human hepatic derived cell lines exposed to ciprofibrate: M.C. Clemencet, et al.; Cancer Lett. 222, 217 (2005) P450 CYP2C epoxygenase and CYP4A w-hydroxylase mediate ciprofibrate-induced PPARa-dependent peroxisomal proliferation: A. Gatica, et al.; J. Lipid Res. 48, 924 (2007) Lalwani ND, Reddy MK, Qureshi SA et al. Hum Toxicol. 2:27-48 (1983). Clemencet MC, Muzio G, Trombetta A et al. Cancer Lett. 222:217-226 (2005).Inhibitor of:
ABCD1, Lipid Biosynthesis, Peroxin 11α, UGT1A10, and UGT1A3.Activator of:
17β-HSD11, ABCD2, ACOX2, ACSL1, apoA-I, CAR, CYP4A22, DHCR24, FMO5, OAT, Peroxin 3, PLTP, PPAR alpha, Sodium Taurochenodeoxycholate, and TYSND1.Ordering Information
| Product Name | Catalog # | UNIT | Price | Qty | FAVORITES | |
Ciprofibrate, 25 mg | sc-204689 | 25 mg | $57.00 | |||
Ciprofibrate, 100 mg | sc-204689A | 100 mg | $169.00 |