5-LO Inhibitors
Santa Cruz Biotechnology now offers a broad range of 5-LO Inhibitors. 5-lipoxygenase (5-LO) is expressed primarily in polymorphonuclear leukocytes, macrophages, and mast cells. 5-LO performs the first two catalytic reactions in the biosynthesis of leukotrienes. 5-LO Inhibitors offered by Santa Cruz inhibit 5-LO and, in some cases, other leukotriene and lipid metabolite biosynthesis related proteins. View detailed 5-LO Inhibitor specifications, including 5-LO Inhibitor CAS number, molecular weight, molecular formula and chemical structure, by clicking on the product name.
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Items 21 to 30 of 53 total
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| Product Name | CAS # | Catalog # | QUANTITY | Price | Citations | RATING |
|---|---|---|---|---|---|---|
Fisetin | 528-48-3 | sc-276440 sc-276440A sc-276440B sc-276440C sc-276440D | 50 mg 100 mg 500 mg 1 g 100 g | $52.00 $79.00 $104.00 $156.00 $2913.00 | 7 | |
Fisetin inhibits 5-LO by reducing the expression of 5-LO protein and its activity, thereby decreasing leukotriene production. | ||||||
STEARDA | 105955-10-0 | sc-204903 | 10 mg | $71.00 | ||
STEARDA acts as a potent 5-lipoxygenase (5-LO) modulator, characterized by its unique ability to form stable complexes with the enzyme through hydrophobic interactions and electrostatic forces. Its structural conformation promotes specific binding to the active site, effectively hindering substrate access. Additionally, STEARDA's reactivity as an acid halide enables it to participate in acylation reactions, influencing downstream signaling pathways and metabolic processes. | ||||||
β-Boswellic Acid | 631-69-6 | sc-210958 | 5 mg | $300.00 | 1 | |
β-Boswellic Acid functions as a selective 5-lipoxygenase (5-LO) inhibitor, exhibiting a unique capacity to disrupt enzyme activity through competitive inhibition. Its molecular structure allows for specific interactions with key amino acid residues, altering the enzyme's conformation and reducing its catalytic efficiency. Furthermore, β-Boswellic Acid's ability to modulate lipid peroxidation pathways highlights its role in influencing cellular signaling dynamics and inflammatory responses. | ||||||
Eicosapentaenoic Acid-d5 | 1197205-73-4 | sc-205304 sc-205304A | 50 µg 500 µg | $104.00 $835.00 | ||
Eicosapentaenoic Acid-d5 serves as a substrate for 5-lipoxygenase (5-LO), facilitating the production of bioactive lipid mediators. Its isotopic labeling enhances tracking in metabolic studies, allowing for precise analysis of enzymatic pathways. The unique carbon chain configuration influences the enzyme's substrate specificity and reaction kinetics, promoting distinct metabolic profiles. Additionally, its interactions with membrane phospholipids can modulate cellular signaling cascades, impacting various physiological processes. | ||||||
Meclofenamate sodium | 6385-02-0 | sc-200532 sc-200532A | 1 g 5 g | $52.00 $79.00 | 2 | |
Meclofenamate sodium acts as a potent inhibitor of 5-lipoxygenase (5-LO), disrupting the enzyme's catalytic activity through competitive binding at the active site. Its unique structural features, including specific functional groups, enhance its affinity for the enzyme, altering reaction kinetics and substrate turnover. This compound's hydrophobic characteristics influence its interaction with lipid membranes, potentially affecting enzyme localization and activity within cellular environments. | ||||||
Zileuton Sulfoxide | 1147524-83-1 | sc-391271 | 5 mg | $340.00 | 1 | |
Zileuton Sulfoxide functions as a selective inhibitor of 5-lipoxygenase (5-LO) by forming stable interactions with the enzyme's active site, effectively modulating its enzymatic activity. The compound's unique stereochemistry and electron-donating groups facilitate specific molecular interactions that alter the enzyme's conformation. Additionally, its solubility properties may influence its distribution in biological systems, impacting the kinetics of lipid metabolism pathways. | ||||||
cis-5,8,11,14,17-Eicosapentaenoic acid sodium salt | 73167-03-0 | sc-214735 sc-214735A | 5 mg 25 mg | $49.00 $192.00 | ||
Cis-5,8,11,14,17-Eicosapentaenoic acid sodium salt acts as a potent modulator of 5-lipoxygenase (5-LO) through its unique polyunsaturated fatty acid structure, which enhances its affinity for the enzyme. The compound's multiple double bonds enable it to engage in specific hydrophobic interactions, influencing the enzyme's catalytic efficiency. Its amphiphilic nature may also affect membrane fluidity, potentially altering lipid signaling pathways and reaction kinetics in cellular environments. | ||||||
Caffeic Acid | 331-39-5 | sc-200499 sc-200499A | 1 g 5 g | $32.00 $62.00 | 1 | |
Caffeic acid exhibits significant modulation of 5-lipoxygenase activity, primarily due to its phenolic structure, which facilitates hydrogen bonding and π-π stacking interactions with the enzyme. This interaction can stabilize enzyme conformations, enhancing substrate accessibility. Additionally, its ability to scavenge free radicals may influence oxidative stress pathways, potentially impacting the kinetics of lipid metabolism and inflammatory responses at the cellular level. | ||||||
Quercetin | 117-39-5 | sc-206089 sc-206089A sc-206089E sc-206089C sc-206089D sc-206089B | 100 mg 500 mg 100 g 250 g 1 kg 25 g | $11.00 $17.00 $110.00 $250.00 $936.00 $50.00 | 33 | |
Quercetin inhibits 5-LO by downregulating the expression of 5-LO protein and interfering with the enzymatic activity, resulting in reduced leukotriene production. | ||||||
Baicalein | 491-67-8 | sc-200494 sc-200494A sc-200494B sc-200494C | 10 mg 100 mg 500 mg 1 g | $32.00 $42.00 $162.00 $292.00 | 12 | |
Baicalein is a flavonoid that demonstrates notable inhibition of 5-lipoxygenase through its unique structural features, including multiple hydroxyl groups that engage in hydrogen bonding with the enzyme's active site. This interaction alters the enzyme's conformation, potentially reducing its catalytic efficiency. Furthermore, baicalein's capacity to chelate metal ions may modulate oxidative stress pathways, influencing lipid peroxidation and cellular signaling cascades. | ||||||