Date published: 2025-9-18

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Zileuton Sulfoxide (CAS 1147524-83-1)

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Alternate Names:
N-Hydroxy-N-[1-(1-oxidobenzo[b]thien-2-yl)ethyl]urea
Application:
Zileuton Sulfoxide is an orally active inhibitor of 5-lipoxygenase
CAS Number:
1147524-83-1
Molecular Weight:
252.29
Molecular Formula:
C11H12N2O3S
For Research Use Only. Not Intended for Diagnostic or Therapeutic Use.
* Refer to Certificate of Analysis for lot specific data.

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Zileuton Sulfoxide is a metabolite of Zileuton, which acts as an orally active inhibitor of 5-lipoxygenase.


Zileuton Sulfoxide (CAS 1147524-83-1) References

  1. Zileuton, a 5-lipoxygenase inhibitor, increases production of thromboxane A2 and platelet aggregation in patients with asthma.  |  Wu, X., et al. 2003. Am J Hematol. 74: 23-5. PMID: 12949886
  2. The 5-lipoxygenase inhibitor zileuton blocks antigen-induced late airway responses, inflammation and airway hyperresponsiveness in allergic sheep.  |  Abraham, WM., et al. 1992. Eur J Pharmacol. 217: 119-26. PMID: 1330588
  3. Glucuronidation of zileuton (A-64077) by human hepatic microsomes.  |  Sweeny, DJ., et al. 1992. Drug Metab Dispos. 20: 328-9. PMID: 1352229
  4. Reduction of renal ischemia-reperfusion injury in 5-lipoxygenase knockout mice and by the 5-lipoxygenase inhibitor zileuton.  |  Patel, NS., et al. 2004. Mol Pharmacol. 66: 220-7. PMID: 15266012
  5. Reduction of the multiple organ injury and dysfunction caused by endotoxemia in 5-lipoxygenase knockout mice and by the 5-lipoxygenase inhibitor zileuton.  |  Collin, M., et al. 2004. J Leukoc Biol. 76: 961-70. PMID: 15328337
  6. Possible involvement of 5-lipoxygenase metabolite in itch-associated response of mosquito allergy in mice.  |  Kuraishi, Y., et al. 2007. J Pharmacol Sci. 105: 41-7. PMID: 17827870
  7. 2-ABT-S-oxide detoxification by glutathione S-transferases A1-1, M1-1 and P1-1: implications for toxicity associated with zileuton.  |  Joshi, EM., et al. 2009. Xenobiotica. 39: 197-204. PMID: 19280518
  8. Increased metabolites of 5-lipoxygenase from hypoxic ovarian cancer cells promote tumor-associated macrophage infiltration.  |  Wen, Z., et al. 2015. Oncogene. 34: 1241-52. PMID: 24662827
  9. The Role of Leukotrienes Inhibitors in the Management of Chronic Inflammatory Diseases.  |  Meshram, D., et al. 2020. Recent Pat Inflamm Allergy Drug Discov. 14: 15-31. PMID: 32000655
  10. Treatment with the 5-Lipoxygenase Antagonist Zileuton Protects Mice from Postoperative Ileus.  |  Enderes, J., et al. 2022. Eur Surg Res. 63: 224-231. PMID: 35184063
  11. Oxaspiro Indiculides from Old Woman Octopus Cistopus indicus as Dual Inhibitors of Inducible Cyclooxygenase and Lipoxygenase.  |  Kunnappilly Paulose, S. and Chakraborty, K. 2022. Chem Biodivers. 19: e202200277. PMID: 35661399
  12. Identification of the human liver cytochrome P450 enzymes involved in the metabolism of zileuton (ABT-077) and its N-dehydroxylated metabolite, Abbott-66193.  |  Machinist, JM., et al. 1995. Drug Metab Dispos. 23: 1163-74. PMID: 8654206
  13. Arachidonic acid metabolites: mediators of inflammation in asthma.  |  Wenzel, SE. 1997. Pharmacotherapy. 17: 3S-12S. PMID: 9017783

Ordering Information

Product NameCatalog #UNITPriceQtyFAVORITES

Zileuton Sulfoxide, 5 mg

sc-391271
5 mg
$340.00