Molecular structure of STEARDA, CAS Number: 105955-10-0
STEARDA (CAS 105955-10-0)
Alternate Names:
N-(3,4-dihydroxyphenethyl)stearamide; N-Stearoyldopamine
Application:
STEARDA is a 5-LO (5-lipoxygenase) inhibitor
CAS Number:
105955-10-0
Purity:
≥92%
Molecular Weight:
419.64
Molecular Formula:
C26H45NO3
For Research Use Only. Not Intended for Diagnostic or Therapeutic Use.
* Refer to Certificate of Analysis for lot specific data.
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SDS & Certificate of Analysis
STEARDA inhibits arachidonate 5-LO (5-lipoxygenase) with an IC50 of 16 nM. Adiditionally, is an ndogenous fatty acid dopamide that displays ′entourage′ effects on endovanilloids NADA and anandamide. STEARDA is inactive at TRPV1 and CB1 receptors (at concentrations up to 5 muM) and does not inhibit AMT or FAAH (IC50 > 25 muM). However, STEARDA potentiates TRPV1-mediated effects of NADA n vitro and n vivo enhances effects on intracellular Ca2+ (EC50 lowered 3-fold) and nociception. Also, STEARDA inhibits arachidonate 5-lipoxygenase (IC50 = 16 nM).
STEARDA (CAS 105955-10-0) References
- N-oleoyldopamine, a novel endogenous capsaicin-like lipid that produces hyperalgesia. | Chu, CJ., et al. 2003. J Biol Chem. 278: 13633-9. PMID: 12569099
- Actions of two naturally occurring saturated N-acyldopamines on transient receptor potential vanilloid 1 (TRPV1) channels. | De Petrocellis, L., et al. 2004. Br J Pharmacol. 143: 251-6. PMID: 15289293
- Significance of the amide functionality on DOPA-based monolayers on gold. | Rībena, D., et al. 2012. Langmuir. 28: 16900-8. PMID: 23157706
- The molecular configuration of a DOPA/ST monolayer at the air-water interface: a molecular dynamics study. | Kong, CP., et al. 2014. Phys Chem Chem Phys. 16: 9634-42. PMID: 24728475
Inhibitor of:
5-LO.Ordering Information
| Product Name | Catalog # | UNIT | Price | Qty | FAVORITES | |
STEARDA, 10 mg | sc-204903 | 10 mg | $71.00 |