4931409K22Rik Activators
Chemical activators of IQ motif containing with AAA domain 1 like can engage various molecular pathways to modulate its activity. Forskolin, by directly stimulating adenylate cyclase, leads to an upsurge in cAMP within the cell. This elevation in cAMP levels activates protein kinase A (PKA), which can phosphorylate IQ motif containing with AAA domain 1 like, enhancing its functional activity. Similarly, Isoproterenol, a beta-adrenergic agonist, increases cAMP levels through its action on adenylate cyclase, leading to the activation of PKA and subsequent phosphorylation of the protein. Dibutyryl-cAMP, a cAMP analog, bypasses upstream signaling and directly activates PKA, which then can target IQ motif containing with AAA domain 1 like. Epinephrine, by binding to beta-adrenergic receptors, triggers a comparable cascade, culminating in PKA-mediated phosphorylation of the protein. Additionally, IBMX, by inhibiting phosphodiesterases that degrade cAMP, indirectly sustains PKA activation, which in turn can maintain the phosphorylation state of IQ motif containing with AAA domain 1 like.
Apart from cAMP-related pathways, calcium-dependent mechanisms also play a role in the activation of IQ motif containing with AAA domain 1 like. Ionomycin and A23187, both calcium ionophores, elevate intracellular calcium levels, which can activate calmodulin-dependent kinase (CaMK). This kinase, in response to increased calcium, can phosphorylate IQ motif containing with AAA domain 1 like. BAY K8644 and FPL 64176 function by augmenting calcium influx through L-type calcium channels, leading to CaMK activation and subsequent phosphorylation of the protein. PDBu, as a PKC activator, mimics diacylglycerol and activates protein kinase C (PKC), which can then phosphorylate IQ motif containing with AAA domain 1 like. Lastly, Calyculin A, by inhibiting the dephosphorylation of proteins, may lead to a sustained phosphorylation state of IQ motif containing with AAA domain 1 like, maintaining its activity. These chemical activators, through diverse signaling pathways, can modulate the activity of IQ motif containing with AAA domain 1 like by altering its phosphorylation status.
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| Product Name | CAS # | Catalog # | QUANTITY | Price | Citations | RATING |
|---|---|---|---|---|---|---|
Isoproterenol Hydrochloride | 51-30-9 | sc-202188 sc-202188A | 100 mg 500 mg | $28.00 $38.00 | 5 | |
Isoproterenol acts as a beta-adrenergic agonist, which can lead to the activation of adenylate cyclase and a subsequent rise in cAMP levels. The increase in cAMP can activate PKA, which may then phosphorylate and activate IQ motif containing with AAA domain 1 like. | ||||||
Ionomycin | 56092-82-1 | sc-3592 sc-3592A | 1 mg 5 mg | $78.00 $270.00 | 80 | |
Ionomycin is a calcium ionophore that increases intracellular calcium levels. Elevated calcium can activate calmodulin-dependent kinase (CaMK), which in turn can phosphorylate and activate proteins with IQ motifs, such as IQ motif containing with AAA domain 1 like. | ||||||
Phorbol-12,13-dibutyrate | 37558-16-0 | sc-202285 | 1 mg | $124.00 | 3 | |
Phorbol 12,13-dibutyrate (PDBu) is a PKC activator, which mimics diacylglycerol. PKC can phosphorylate a variety of proteins, potentially including IQ motif containing with AAA domain 1 like, thereby enhancing its activity. | ||||||
Anisomycin | 22862-76-6 | sc-3524 sc-3524A | 5 mg 50 mg | $99.00 $259.00 | 36 | |
Anisomycin is a JNK activator, which can lead to the activation of c-Jun N-terminal kinase (JNK) pathway. JNK can phosphorylate several downstream targets, which may include proteins with IQ motifs, thus activating IQ motif containing with AAA domain 1 like. | ||||||
A23187 | 52665-69-7 | sc-3591 sc-3591B sc-3591A sc-3591C | 1 mg 5 mg 10 mg 25 mg | $55.00 $131.00 $203.00 $317.00 | 23 | |
A23187 is another calcium ionophore that increases intracellular Ca2+ concentration, activating CaMK, which could then phosphorylate and activate IQ motif containing with AAA domain 1 like through its IQ motif. | ||||||
(±)-Bay K 8644 | 71145-03-4 | sc-203324 sc-203324A sc-203324B | 1 mg 5 mg 50 mg | $84.00 $196.00 $817.00 | ||
BAY K8644 acts as an L-type calcium channel agonist, increasing calcium influx. The increased calcium levels can activate CaMK, potentially resulting in the phosphorylation and activation of IQ motif containing with AAA domain 1 like. | ||||||
Calyculin A | 101932-71-2 | sc-24000 sc-24000A | 10 µg 100 µg | $163.00 $800.00 | 59 | |
Calyculin A is a phosphatase inhibitor that prevents dephosphorylation of proteins. By inhibiting protein phosphatase activity, it could lead to sustained phosphorylation and activation of IQ motif containing with AAA domain 1 like. | ||||||
Dibutyryl-cAMP | 16980-89-5 | sc-201567 sc-201567A sc-201567B sc-201567C | 20 mg 100 mg 500 mg 10 g | $47.00 $136.00 $492.00 $4552.00 | 74 | |
Dibutyryl-cAMP is a cell-permeable cAMP analog that activates PKA. Once activated, PKA may phosphorylate IQ motif containing with AAA domain 1 like, leading to its functional activation. | ||||||
(−)-Epinephrine | 51-43-4 | sc-205674 sc-205674A sc-205674B sc-205674C sc-205674D | 1 g 5 g 10 g 100 g 1 kg | $41.00 $104.00 $201.00 $1774.00 $16500.00 | ||
Epinephrine interacts with beta-adrenergic receptors, stimulating adenylate cyclase, increasing cAMP, and activating PKA. PKA then could phosphorylate IQ motif containing with AAA domain 1 like, leading to its activation. | ||||||
FPL-64176 | 120934-96-5 | sc-201491 | 5 mg | $83.00 | 1 | |
FPL 64176 is a calcium channel activator which increases Ca2+ influx, potentially activating CaMK, and subsequently phosphorylating and activating IQ motif containing with AAA domain 1 like. | ||||||