3 BP-1 Activators
3 BP-1 Activators encompass a spectrum of chemical compounds that indirectly bolster the functional activity of 3 BP-1 by modulating various signaling pathways. Forskolin, by stimulating adenylyl cyclase, amplifies intracellular cAMP levels, which in turn activates protein kinase A (PKA), a kinase that can phosphorylate targets to enhance 3 BP-1 activity. Similarly, IBMX and Rolipram, by inhibiting different phosphodiesterases, lead to an accumulation of cAMP, indirectly promoting 3 BP-1's functional activities through the same PKA-dependent mechanism. Sildenafil and Zaprinast, both PDE5 inhibitors, as well as Vinpocetine, a PDE1 inhibitor, and Anagrelide, a PDE3 inhibitor, all raise either cAMP or cGMP levels, which could indirectly boost 3 BP-1 activity through the activation of PKA or PKG. The kinase inhibitor Epigallocatechin gallate (EGCG) may contribute to the enhancement of 3 BP-1 activity by reducing competitive inhibitory phosphorylation events, thereby favoring 3 BP-1 functional pathways.
In addition to these, Okadaic acid, by inhibiting protein phosphatases 1 and 2A, may lead to a heightened state of phosphorylation within the cell, which could indirectly result in the enhancement of 3 BP-1 activity. Dipyridamole, Milrinone, and Cilostazol, as phosphodiesterase inhibitors, elevate cAMP levels, further potentiating 3 BP-1 activity through PKA signaling. Notably, these activators work by influencing the balance of phosphorylation and dephosphorylation, or by modulating the levels of secondary messengers within the cell, rather than directly binding to 3 BP-1. Collectively, the actions of these compounds converge on pathways that lead to the activation of 3 BP-1, ensuring that the protein'sfunctional roles are supported and augmented by these chemical modulators.
SEE ALSO...
Items 1 to 10 of 12 total
Display:
| Product Name | CAS # | Catalog # | QUANTITY | Price | Citations | RATING |
|---|---|---|---|---|---|---|
Forskolin | 66575-29-9 | sc-3562 sc-3562A sc-3562B sc-3562C sc-3562D | 5 mg 50 mg 1 g 2 g 5 g | $78.00 $153.00 $740.00 $1413.00 $2091.00 | 73 | |
Activates adenylate cyclase, increasing cAMP levels. This elevation promotes PKA activation, which can phosphorylate and thereby enhance the tumor suppressor functions of 3 BP-1, leading to the suppression of cell proliferation and induction of apoptosis in cancer cells. | ||||||
D,L-Sulforaphane | 4478-93-7 | sc-207495A sc-207495B sc-207495C sc-207495 sc-207495E sc-207495D | 5 mg 10 mg 25 mg 1 g 10 g 250 mg | $153.00 $292.00 $489.00 $1325.00 $8465.00 $933.00 | 22 | |
Induces Nrf2-mediated signaling pathways. Nrf2 activation leads to the transcriptional activation of antioxidant response element (ARE)-regulated genes, which can include TUSC2, thereby enhancing the functional activity of 3 BP-1 in oxidative stress response. | ||||||
Curcumin | 458-37-7 | sc-200509 sc-200509A sc-200509B sc-200509C sc-200509D sc-200509F sc-200509E | 1 g 5 g 25 g 100 g 250 g 1 kg 2.5 kg | $37.00 $69.00 $109.00 $218.00 $239.00 $879.00 $1968.00 | 47 | |
Modulates the NF-κB pathway, inhibiting its activation. Since 3 BP-1 is implicated in the negative regulation of NF-κB, curcumin can enhance the activity of 3 BP-1 by reducing competitive inhibition from NF-κB, promoting apoptosis in tumorigenic cells. | ||||||
Resveratrol | 501-36-0 | sc-200808 sc-200808A sc-200808B | 100 mg 500 mg 5 g | $80.00 $220.00 $460.00 | 64 | |
Sirtuin activator that can deacetylate proteins like p53, enhancing their tumor suppressor functions. This activation of sirtuins can support the tumor suppressive role of 3 BP-1 through indirect pathways like p53 signaling that are involved in apoptosis and cell cycle regulation. | ||||||
Piperlongumine | 20069-09-4 | sc-364128 | 10 mg | $107.00 | ||
Increases ROS levels within cells, leading to oxidative stress. 3 BP-1, through its tumor suppressor activities, may be enhanced as cells respond to oxidative stress by activating cell death pathways where 3 BP-1 is implicated. | ||||||
Parthenolide | 20554-84-1 | sc-3523 sc-3523A | 50 mg 250 mg | $81.00 $306.00 | 32 | |
Inhibits NF-κB signaling, which may enhance the function of 3 BP-1 by alleviating the inhibitory effects of NF-κB on apoptosis, thus supporting 3 BP-1’s role in inducing cell death in cancer cells. | ||||||
Quercetin | 117-39-5 | sc-206089 sc-206089A sc-206089E sc-206089C sc-206089D sc-206089B | 100 mg 500 mg 100 g 250 g 1 kg 25 g | $11.00 $17.00 $110.00 $250.00 $936.00 $50.00 | 33 | |
Inhibits PI3K/Akt signaling, which can elevate the pro-apoptotic function of 3 BP-1 as this pathway is often dysregulated in cancer, leading to increased cell survival and proliferation. | ||||||
(−)-Epigallocatechin Gallate | 989-51-5 | sc-200802 sc-200802A sc-200802B sc-200802C sc-200802D sc-200802E | 10 mg 50 mg 100 mg 500 mg 1 g 10 g | $43.00 $73.00 $126.00 $243.00 $530.00 $1259.00 | 11 | |
Inhibits multiple kinases and modulates signaling pathways associated with cell proliferation. By influencing these pathways, EGCG can enhance the activity of 3 BP-1, which is involved in suppressing cell proliferation and inducing apoptosis. | ||||||
Indole-3-carbinol | 700-06-1 | sc-202662 sc-202662A sc-202662B sc-202662C sc-202662D | 1 g 5 g 100 g 250 g 1 kg | $39.00 $61.00 $146.00 $312.00 $1032.00 | 5 | |
Modulates estrogen receptor signaling and affects cell cycle regulation. Indole-3-carbinol may enhance the functional activity of 3 BP-1 by modulating pathways involved in cell cycle arrest and apoptosis in cancer cells. | ||||||
Disulfiram | 97-77-8 | sc-205654 sc-205654A | 50 g 100 g | $53.00 $89.00 | 7 | |
Inhibits aldehyde dehydrogenase and NF-κB pathway, potentially enhancing the activity of 3 BP-1 by promoting its role in apoptosis and by reducing the proliferative signals that are antagonistic to 3 BP-1’s function. | ||||||