2400001E08Rik Activators
LAMTOR1 Activators are a group of chemical compounds that either directly or indirectly lead to the enhancement of LAMTOR1's functional activity, primarily through the modulation of the mTORC1 signaling pathway, which LAMTOR1 is intrinsically involved in. The amino acid Leucine is known to activate mTORC1 by stimulating Rag GTPases, which in turn require the localization provided by LAMTOR1 to the lysosomal membrane, thus potentiating LAMTOR1's role in mTORC1 activation. Similarly, amino acids like Glutamine can increase the intracellular levels of metabolites that are needed for mTORC1 activation, which indirectly suggests an enhancement of LAMTOR1's activity due to its association with mTORC1. Moreover, signaling molecules such as Insulin can activate the PI3K/Akt pathway, further leading to mTORC1 activation, implicating an indirect upregulation of LAMTOR1 activity as it is essential for the proper functioning of mTORC1.
On the other hand, compounds that inhibit mTORC1, like Rapamycin, AICAR, and Resveratrol, which activate AMPK leading to mTORC1 inhibition, could potentially cause a compensatory increase in LAMTOR1 activity as the cell attempts to reactivate mTORC1. This is an indirect mechanism where the inhibition of the pathway could lead to feedback mechanisms that enhance the activity of pathway components, including LAMTOR1. Compounds like Spermidine and Palmitoylcarnitine, which can affect autophagy and fatty acid signaling, respectively, also have the potential to indirectly enhance LAMTOR1 activity by modulating the mTORC1 pathway. Lysophosphatidic acid, through its G protein-coupled receptors, and Zinc, through modulation of phosphatases and kinases, are additional examples of compounds that can indirectly influence LAMTOR1 activity via the mTORC1 signaling pathway. These various compounds illustrate the complex regulatory network that can impact the functional activity of LAMTOR1, through both direct stimulation of the mTORC1 pathway and indirect feedback and compensatory mechanisms.
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| Product Name | CAS # | Catalog # | QUANTITY | Price | Citations | RATING |
|---|---|---|---|---|---|---|
Rapamycin | 53123-88-9 | sc-3504 sc-3504A sc-3504B | 1 mg 5 mg 25 mg | $62.00 $155.00 $320.00 | 233 | |
Rapamycin is an mTOR inhibitor that leads to a reduction in mTORC1 activity. Since LAMTOR1 is essential for mTORC1 activation, the inhibition of mTORC1 by rapamycin may lead to a compensatory increase in LAMTOR1 activity as the cell attempts to reactivate mTORC1. | ||||||
L-Leucine | 61-90-5 | sc-364173 sc-364173A | 25 g 100 g | $21.00 $61.00 | ||
Leucine is an amino acid that activates mTORC1 by stimulating Rag GTPases. LAMTOR1 is crucial for localizing Rag GTPases to the lysosomal membrane where mTORC1 is activated, thus leucine enhances LAMTOR1 activity by promoting mTORC1 activation through Rag GTPases. | ||||||
AICAR | 2627-69-2 | sc-200659 sc-200659A sc-200659B | 50 mg 250 mg 1 g | $60.00 $270.00 $350.00 | 48 | |
AICAR is an AMPK activator that inhibits mTORC1 activity by mimicking AMP. The inhibition of mTORC1 through AMPK activation by AICAR may result in a compensatory increase in LAMTOR1 activity as the cell attempts to restore mTORC1 activity. | ||||||
Metformin-d6, Hydrochloride | 1185166-01-1 | sc-218701 sc-218701A sc-218701B | 1 mg 5 mg 10 mg | $286.00 $806.00 $1510.00 | 1 | |
Metformin activates AMPK leading to an indirect inhibition of mTORC1 signaling. This inhibition of mTORC1 by metformin could lead to a compensatory increase in the activity of LAMTOR1 as part of the cellular response to restore mTORC1 activity. | ||||||
Spermidine | 124-20-9 | sc-215900 sc-215900B sc-215900A | 1 g 25 g 5 g | $56.00 $595.00 $173.00 | ||
Spermidine induces autophagy through inhibiting the acetyltransferase EP300. Since autophagy is regulated by mTORC1, and LAMTOR1 is involved in mTORC1 activation, spermidine enhances LAMTOR1 activity indirectly by modulating mTORC1 activity through autophagy regulation. | ||||||
Lysophosphatidic Acid | 325465-93-8 | sc-201053 sc-201053A | 5 mg 25 mg | $96.00 $334.00 | 50 | |
Lysophosphatidic acid activates mTOR signaling indirectly through its G protein-coupled receptors. This activation enhances the functional activity of LAMTOR1 as it is part of the mTORC1 activation complex and mTORC1 signaling is increased. | ||||||
Insulin | 11061-68-0 | sc-29062 sc-29062A sc-29062B | 100 mg 1 g 10 g | $153.00 $1224.00 $12239.00 | 82 | |
Insulin activates the PI3K/Akt pathway, which in turn activates mTORC1. LAMTOR1's activity is indirectly enhanced through the insulin-induced activation of mTORC1, as it is essential for mTORC1 activity. | ||||||
β-Nicotinamide mononucleotide | 1094-61-7 | sc-212376 sc-212376A sc-212376B sc-212376C sc-212376D | 25 mg 100 mg 1 g 2 g 5 g | $92.00 $269.00 $337.00 $510.00 $969.00 | 4 | |
NMN elevates NAD+ levels, which can enhance SIRT1 activity that deacetylates and activates LKB1, leading to AMPK activation. The activation of AMPK inhibits mTORC1, potentially resulting in a compensatory increase in LAMTOR1 activity to restore mTORC1 function. | ||||||
L-Glutamine | 56-85-9 | sc-391013 sc-391013C sc-391013A sc-391013D sc-391013B | 100 g 250 g 1 kg 5 kg 10 kg | $36.00 $46.00 $97.00 $372.00 $719.00 | 2 | |
Glutamine activates mTORC1 by increasing intracellular glutamate and α-ketoglutarate levels, necessary for mTORC1 activation. As part of the Ragulator complex, LAMTOR1 indirectly experiences enhanced activity through the glutamine-mediated activation of mTORC1. | ||||||
Resveratrol | 501-36-0 | sc-200808 sc-200808A sc-200808B | 100 mg 500 mg 5 g | $60.00 $185.00 $365.00 | 64 | |
Resveratrol activates AMPK and inhibits mTORC1 activity. This inhibition can lead to a compensatory upregulation of LAMTOR1 activity as the cell attempts to restore mTORC1 activity. | ||||||