15-LO2 Activators

15-LO2 activators, in this context, refer to chemicals that indirectly influence the activity of 15-Lipoxygenase-2. 15-LO2 is an enzyme that plays a significant role in the metabolism of polyunsaturated fatty acids (PUFAs) and is involved in various physiological processes, including inflammation, cell proliferation, and apoptosis. Direct activators targeting 15-LO2 are less commonly identified, so the focus here is on substances that impact metabolic pathways or cellular processes related to its function. Fatty acids such as Arachidonic Acid, Linoleic Acid, Gamma-Linolenic Acid (GLA), Eicosapentaenoic Acid (EPA), and Docosahexaenoic Acid (DHA) serve as direct substrates for 15-LO2. These fatty acids are essential for the enzyme's catalytic activity in metabolizing lipids and producing bioactive lipid mediators.

Compounds like Aspirin can indirectly modulate 15-LO2 activity by influencing the acetylation of the enzyme and its substrates, thereby affecting the enzyme's function. Curcumin, Resveratrol, and Quercetin impact lipid metabolism and inflammatory pathways, potentially influencing 15-LO2 activity. These compounds are known for their roles in modulating oxidative stress and inflammation, which are relevant to the functions of 15-LO2. Sulforaphane and Green Tea Extract, containing Epigallocatechin gallate (EGCG), are also potential modulators of 15-LO2. They influence oxidative stress and inflammation, processes in which 15-LO2 plays a role. Omega-3 Fatty Acids, in general, act as substrates for 15-LO2 and are involved in the production of anti-inflammatory lipid mediators. Understanding the indirect modulation of 15-LO2 by these chemicals provides insights into the regulation of lipid metabolism and the inflammatory response.