Molecular structure of α-Linolenic Acid, CAS Number: 463-40-1
α-Linolenic Acid (CAS 463-40-1)
See product citations (2)
Alternate Names:
Octadeca-9Z,12Z,15Z-trienoic acid; α-Lnn; cis,cis,cis-9,12,15-Octadecatrienoic acid
Application:
α-Linolenic Acid is a polyunsaturated essential fatty acid
CAS Number:
463-40-1
Purity:
>98%
Molecular Weight:
278.43
Molecular Formula:
C18H30O2
For Research Use Only. Not Intended for Diagnostic or Therapeutic Use.
* Refer to Certificate of Analysis for lot specific data.
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α-Linolenic Acid (ALA), an 18 carbon polyunsaturated essential fatty acid, has been found to exert in vitro anti-inflammatory effects in murine intestine. Mechanistic studies suggest that this compound decreases TNFalpha (tumor necrosis factor-alpha) secretion levels as well as NF-kappaB activation. Additionally, α-Linolenic Acid has been noted to be a reactive oxygen species scavenger that temporarily improves cell proliferation. Further experiments report that an increase in α-Linolenic Acid levels seems to be correlated inversely with plasma IL-6 (interleukin-6) soluble receptor levels.
α-Linolenic Acid (CAS 463-40-1) References
- High habitual dietary alpha-linolenic acid intake is associated with decreased plasma soluble interleukin-6 receptor concentrations in male twins. | Dai, J., et al. 2010. Am J Clin Nutr. 92: 177-85. PMID: 20463041
- An α-linolenic acid-rich formula reduces oxidative stress and inflammation by regulating NF-κB in rats with TNBS-induced colitis. | Hassan, A., et al. 2010. J Nutr. 140: 1714-21. PMID: 20724486
- Alpha-linolenic acid: is it essential to cardiovascular health? | Geleijnse, JM., et al. 2010. Curr Atheroscler Rep. 12: 359-67. PMID: 20814766
- Effect of N-acetyl cysteine and alpha-linolenic acid on sulfur mustard caused impairment of in vitro endothelial tube formation. | Steinritz, D., et al. 2010. Toxicol Sci. 118: 521-9. PMID: 20833707
- Lymphatic absorption of α-linolenic acid in rats fed flaxseed oil-based emulsion. | Couëdelo, L., et al. 2011. Br J Nutr. 105: 1026-35. PMID: 21080982
- The health promoting properties of the conjugated isomers of α-linolenic acid. | Hennessy, AA., et al. 2011. Lipids. 46: 105-19. PMID: 21161605
- Protective effect of alpha-linolenic acid on gentamicin-induced ototoxicity in mice. | Kaplan, HM., et al. 2017. Somatosens Mot Res. 34: 145-150. PMID: 28760048
- Genotoxicity evaluation of alpha-linolenic acid-diacylglycerol oil. | Honda, H., et al. 2016. Toxicol Rep. 3: 716-722. PMID: 28959597
- α-Linolenic acid inhibits Tau aggregation and modulates Tau conformation. | Desale, SE., et al. 2021. Int J Biol Macromol. 166: 687-693. PMID: 33130263
- Dietary Alpha-Linolenic Acid Supports High Retinal DHA Levels. | Sinclair, AJ., et al. 2022. Nutrients. 14: PMID: 35057481
- Fatty acid synthases and desaturases are essential for the biosynthesis of α-linolenic acid and metamorphosis in a major mulberry pest, Glyphodes pyloalis walker (Lepidoptera: Pyralidae). | Wang, J., et al. 2022. Pest Manag Sci. 78: 2629-2642. PMID: 35362207
- α-Linolenic Acid Suppresses Proliferation and Invasion in Osteosarcoma Cells via Inhibiting Fatty Acid Synthase. | Fan, H., et al. 2022. Molecules. 27: PMID: 35566090
- Alpha-linolenic acid inhibits hepatocellular carcinoma cell growth through Farnesoid X receptor/β-catenin signaling pathway. | Feng, S., et al. 2022. Nutr Metab (Lond). 19: 57. PMID: 35999582
Inhibitor of:
neogenin, Peroxin 11α, PM20D1, and SRD5A2L.Activator of:
15-LO2, 17β-HSD12, 4833423E24Rik, ABHD15, ACOT4, ACSL1, ACSM5, ACSVL6, apoAL, ASAHL, CBR4, CYP2J12, CYP2J2, CYP4A1, CYP4A11, Cyp4f13, CYP4F22, Cyp4f37, DECR2, DNA pol ε 4, ELOVL2, ELOVL5, ELOVL7, encephalopsin, Ethanolamine kinase 2, FAAH2, FABP12, FACL5, FADS3, FGF-14, GNPAT, GPAT2, GPR120, GPR18, GPR40, GPR84, Keratin 33A, Keratin 36, KRTAP9-1, LERK-3, LIR-6, LOC100041119, LOC647264, LPCAT1, LPL, MBOAT4, MBOAT5, NAPE-PLD, NrCAM, OR11L1, PAcP, PI 3-kinase p101, PIP2, PPAR alpha, PTPLB, RDH19, SCD1, SCD5, Synaptotagmin VIII, TREK-1, UGT8, and ZADH1.Ordering Information
| Product Name | Catalog # | UNIT | Price | Qty | FAVORITES | |
α-Linolenic Acid, 50 mg | sc-205545 | 50 mg | $37.00 | |||
α-Linolenic Acid, 250 mg | sc-205545A | 250 mg | $113.00 |