alpha-Linolenic Acid CAS: 463-40-1
MF: C18H30O2
MW: 278.43
A polyunsaturated essential fatty acid.

α-Linolenic Acid (CAS 463-40-1)

α-Linolenic Acid | CAS 463-40-1 is rated 5.0 out of 5 by 2.
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Alternate Names: Octadeca-9Z,12Z,15Z-trienoic acid; α-Lnn; cis,cis,cis-9,12,15-Octadecatrienoic acid
Application: α-Linolenic Acid is a polyunsaturated essential fatty acid
CAS Number: 463-40-1
Purity: >98%
Molecular Weight: 278.43
Molecular Formula: C18H30O2
For Research Use Only. Not Intended for Diagnostic or Therapeutic Use.
* Refer to Certificate of Analysis for lot specific data (including water content).

α-Linolenic Acid (ALA), an 18 carbon polyunsaturated essential fatty acid, has been found to exert in vitro anti-inflammatory effects in murine intestine. Mechanistic studies suggest that this compound decreases TNFα (tumor necrosis factor-α) secretion levels as well as NF-κB activation. Additionally, ALA has been noted to be a reactive oxygen species scavenger that temporarily improves cell proliferation. Further experiments report that an increase in ALA levels seems to be correlated inversely with plasma IL-6 (interleukin-6) soluble receptor levels.


References

1. Dai, J., et al. 2010. Am. J. Clin. Nutr. 92: 177-185. PMID: 20463041
2. Couëdelo, L., et al. 2010. Br. J. Nutr. 1-10. PMID: 21080982
3. Geleijnse, J.M., et al. 2010. Curr Atheroscler Rep. 12: 359-367. PMID: 20814766
4. Hassan, A., et al. 2010. J. Nutr. 140: 1714-1721. PMID: 20724486
5. Hennessy, A.A., et al. 2010. Lipids. [Epub ahead of print]. PMID: 21161605
6. Steinritz, D., et al. 2010. Toxicol. Sci. 118: 521-529. PMID: 20833707

Physical State :
Liquid
Storage :
Store at -20° C
Melting Point :
-11° C (lit.)
Boiling Point :
230-232° C at 1 mmHg
Density :
0.92 g/ml
For Research Use Only. Not Intended for Diagnostic or Therapeutic Use.
PubChem CID :
MDL Number :
MFCD00065720
EC Number :
207-334-8
SMILES :
CC/C=C\\C/C=C\\C/C=C\\CCCCCCCC(=O)O

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Certificate of Analysis

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alpha-Linolenic Acid (CAS 463-40-1)  Product Citations

See how others have used alpha-Linolenic Acid (CAS 463-40-1). Click on the entry to view the PubMed entry .

Citations 1 to 2 of 2 total

PMID: # 28973946  Lopez, MS. et al. 2017. Proc. Natl. Acad. Sci. U.S.A. 114: 11223-11228.

PMID: # 26681780  J Lipid Res. 207-18.

Citations 1 to 2 of 2 total
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Rated 5 out of 5 by from Good solubility We dissolved it in dmso and used it in tissue culture. It worked very well.
Date published: 2017-02-24
Rated 5 out of 5 by from Relevant assays for usage as analytical standards Relevant assays for usage as analytical standards.
Date published: 2015-06-08
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