14-3-3 σ Activators
The chemical class of 14-3-3 σ activators presents a diverse array of compounds strategically designed to modulate the activity of 14-3-3 σ, a regulatory protein with critical involvement in various cellular processes. These activators can be broadly classified into two groups: those that directly interact with 14-3-3 σ and those that exert their influence indirectly by targeting key cellular pathways. Direct activators, such as SB216763, SC79, LY294002, Akt Inhibitor VIII, Triciribine, GSK-3 Inhibitor IX, Akt Inhibitor IV, Perifosine, SC66, Wortmannin, AKT Inhibitor II, and Akt Inhibitor VI, play a significant role in directly engaging with 14-3-3 σ. Among these, SB216763 and GSK-3 Inhibitor IX, functioning as GSK-3 inhibitors, indirectly activate 14-3-3 σ by preventing its phosphorylation and degradation, ultimately leading to an increase in protein levels. SC79 and SC66, identified as Akt activators, indirectly activate 14-3-3 σ by promoting Akt-dependent phosphorylation and stabilization. Additionally, LY294002, Triciribine, Akt Inhibitor IV, Perifosine, Wortmannin, AKT Inhibitor II, and Akt Inhibitor VI, categorized as Akt inhibitors, indirectly activate 14-3-3 σ by inhibiting Akt-dependent phosphorylation and stabilization, resulting in decreased protein levels. These direct activators highlight the multifaceted interplay between 14-3-3 σ and key signaling pathways like GSK-3 and Akt.
Indirect activators underscore the complex relationship between 14-3-3 σ and signaling pathways. Understanding how these compounds modulate 14-3-3 σ activity provides valuable insights into the intricate regulatory mechanisms governing cellular processes in which 14-3-3 σ is intricately involved. The indirect activation mechanisms shed light on the intricate interplay between 14-3-3 σ and key cellular pathways, offering researchers a comprehensive toolkit to explore and unravel the regulatory intricacies of this essential protein. The chemical class of 14-3-3 σ activators thus emerges as a valuable resource for researchers aiming to decipher the role of 14-3-3 σ in cellular processes and develop a nuanced understanding of the intricate signaling networks it engages in
SEE ALSO...
| Product Name | CAS # | Catalog # | QUANTITY | Price | Citations | RATING |
|---|---|---|---|---|---|---|
SB-216763 | 280744-09-4 | sc-200646 sc-200646A | 1 mg 5 mg | $70.00 $198.00 | 18 | |
SB216763, a GSK-3 inhibitor, indirectly activates 14-3-3 σ by inhibiting GSK-3 activity. Inhibition of GSK-3 prevents the phosphorylation and degradation of 14-3-3 σ, leading to its stabilization and increased protein levels. This indirect activation highlights the role of GSK-3 in regulating 14-3-3 σ turnover and suggests a potential strategy to modulate 14-3-3 σ levels through the inhibition of GSK-3. | ||||||
2-Amino-6-chloro-α-cyano-3-(ethoxycarbonyl)-4H-1-benzopyran-4-acetic Acid Ethyl Ester | 305834-79-1 | sc-479756 | 25 mg | $380.00 | ||
SC79, an Akt activator, indirectly activates 14-3-3 σ by promoting Akt-dependent phosphorylation and stabilization. Akt activation prevents the degradation of 14-3-3 σ, leading to increased protein levels. This indirect activation reveals the involvement of Akt signaling in the regulation of 14-3-3 σ and provides insights into potential modulators of 14-3-3 σ activity through the activation of Akt. | ||||||
LY 294002 | 154447-36-6 | sc-201426 sc-201426A | 5 mg 25 mg | $121.00 $392.00 | 148 | |
LY294002, a PI3K inhibitor, indirectly activates 14-3-3 σ by modulating the PI3K/Akt pathway. PI3K inhibition influences Akt phosphorylation, impacting 14-3-3 σ stabilization and increasing protein levels. This indirect activation reveals a link between PI3K/Akt signaling and 14-3-3 σ regulation, suggesting a potential strategy to modulate 14-3-3 σ activity through the inhibition of PI3K. | ||||||
Akt Inhibitor VIII, Isozyme-Selective, Akti-1/2 | 612847-09-3 | sc-202048 sc-202048A | 1 mg 5 mg | $204.00 $265.00 | 29 | |
Akt Inhibitor VIII, an Akt inhibitor, indirectly activates 14-3-3 σ by inhibiting Akt-dependent phosphorylation and stabilization. Akt inhibition promotes the degradation of 14-3-3 σ, leading to decreased protein levels. This indirect activation highlights the dependence of 14-3-3 σ on Akt signaling and suggests a potential strategy to modulate 14-3-3 σ activity through the inhibition of Akt. | ||||||
Triciribine | 35943-35-2 | sc-200661 sc-200661A | 1 mg 5 mg | $102.00 $138.00 | 14 | |
Triciribine, an Akt inhibitor, indirectly activates 14-3-3 σ by inhibiting Akt-dependent phosphorylation and stabilization. Akt inhibition promotes the degradation of 14-3-3 σ, leading to decreased protein levels. This indirect activation underscores the role of Akt signaling in the regulation of 14-3-3 σ and provides insights into potential modulators of 14-3-3 σ activity through the inhibition of Akt. | ||||||
GSK-3 Inhibitor IX | 667463-62-9 | sc-202634 sc-202634A sc-202634B | 1 mg 10 mg 50 mg | $57.00 $184.00 $867.00 | 10 | |
GSK-3 Inhibitor IX, a GSK-3 inhibitor, indirectly activates 14-3-3 σ by inhibiting GSK-3 activity. Inhibition of GSK-3 prevents the phosphorylation and degradation of 14-3-3 σ, leading to its stabilization and increased protein levels. This indirect activation highlights the role of GSK-3 in regulating 14-3-3 σ turnover and suggests a potential strategy to modulate 14-3-3 σ levels through the inhibition of GSK-3. | ||||||
Akt Inhibitor IV | 681281-88-9 | sc-203809 sc-203809A | 5 mg 25 mg | $173.00 $695.00 | 42 | |
Akt Inhibitor IV, an Akt inhibitor, indirectly activates 14-3-3 σ by inhibiting Akt-dependent phosphorylation and stabilization. Akt inhibition promotes the degradation of 14-3-3 σ, leading to decreased protein levels. This indirect activation emphasizes the dependence of 14-3-3 σ on Akt signaling and suggests a potential strategy to modulate 14-3-3 σ activity through the inhibition of Akt. | ||||||
Perifosine | 157716-52-4 | sc-364571 sc-364571A | 5 mg 10 mg | $184.00 $321.00 | 1 | |
Perifosine, an Akt inhibitor, indirectly activates 14-3-3 σ by inhibiting Akt-dependent phosphorylation and stabilization. Akt inhibition promotes the degradation of 14-3-3 σ, leading to decreased protein levels. This indirect activation reveals the involvement of Akt signaling in the regulation of 14-3-3 σ and provides insights into potential modulators of 14-3-3 σ activity through the inhibition of Akt. | ||||||
Wortmannin | 19545-26-7 | sc-3505 sc-3505A sc-3505B | 1 mg 5 mg 20 mg | $66.00 $219.00 $417.00 | 97 | |
Wortmannin, a PI3K inhibitor, indirectly activates 14-3-3 σ by modulating the PI3K/Akt pathway. PI3K inhibition influences Akt phosphorylation, impacting 14-3-3 σ stabilization and increasing protein levels. This indirect activation reveals a link between PI3K/Akt signaling and 14-3-3 σ regulation, suggesting a potential strategy to modulate 14-3-3 σ activity through the inhibition of PI3K. | ||||||