MA3 Activators
MA3 activators are a group of chemicals that directly or indirectly influence the functional activity of MA3. They exert their effects by modulating various signaling pathways or biological processes that MA3 is involved in. For instance, Phorbol 12-Myristate 13-Acetate is a known activator of protein kinase C (PKC). By activating PKC, it triggers PKC-mediated signaling pathways that can enhance MA3 functional activity. Likewise, Calyculin A is an inhibitor of protein phosphatases 1 and 2A. By inhibiting these phosphatases, it allows for increased phosphorylation of proteins. MA3, being a substrate for these phosphatases, has its activity enhanced through this process.
Moreover, some MA3 activators influence the protein's activity by modulating intracellular calcium levels. For example, Ionomycin, a calcium ionophore, increases intracellular calcium levels, thereby enhancing MA3 activity when it functions in a calcium-dependent manner. Similarly, Thapsigargin increases intracellular calcium levels, enhancing MA3 activity when it functions in a calcium-dependent manner. Bay K 8644 is another activator of this class; it activates L-type calcium channels, leading to an increase in intracellular calcium levels. This increase can enhance MA3 activity when it functions in a calcium-dependent manner.
| Product Name | CAS # | Catalog # | QUANTITY | Price | Citations | RATING |
|---|---|---|---|---|---|---|
PMA | 16561-29-8 | sc-3576 sc-3576A sc-3576B sc-3576C sc-3576D | 1 mg 5 mg 10 mg 25 mg 100 mg | $41.00 $132.00 $214.00 $500.00 $948.00 | 119 | |
Activates protein kinase C (PKC), which can enhance MA3 activity through PKC-mediated signaling pathways. | ||||||
Calyculin A | 101932-71-2 | sc-24000 sc-24000A | 10 µg 100 µg | $163.00 $800.00 | 59 | |
Inhibits protein phosphatases 1 and 2A, leading to increased phosphorylation of proteins and enhanced activity of MA3 as a substrate for these phosphatases. | ||||||
Forskolin | 66575-29-9 | sc-3562 sc-3562A sc-3562B sc-3562C sc-3562D | 5 mg 50 mg 1 g 2 g 5 g | $78.00 $153.00 $740.00 $1413.00 $2091.00 | 73 | |
Activates adenylyl cyclase, increasing intracellular levels of cAMP and enhancing MA3 activity through cAMP-dependent pathways. | ||||||
Ionomycin, free acid | 56092-81-0 | sc-263405 sc-263405A | 1 mg 5 mg | $96.00 $264.00 | 2 | |
Acts as a calcium ionophore, increasing intracellular calcium levels and enhancing MA3 activity when it functions in a calcium-dependent manner. | ||||||
Okadaic Acid | 78111-17-8 | sc-3513 sc-3513A sc-3513B | 25 µg 100 µg 1 mg | $291.00 $530.00 $1800.00 | 78 | |
Inhibits protein phosphatases 1 and 2A, leading to increased phosphorylation of proteins and enhanced activity of MA3 as a substrate for these phosphatases. | ||||||
KN-93 | 139298-40-1 | sc-202199 | 1 mg | $182.00 | 25 | |
Inhibits CaM kinase II. MA3’s activity is enhanced as this kinase is regulated by KN-93. | ||||||
Thapsigargin | 67526-95-8 | sc-24017 sc-24017A | 1 mg 5 mg | $136.00 $446.00 | 114 | |
Inhibits the ER calcium ATPase, increasing intracellular calcium levels and enhancing MA3 activity when it functions in a calcium-dependent manner. | ||||||
Genistein | 446-72-0 | sc-3515 sc-3515A sc-3515B sc-3515C sc-3515D sc-3515E sc-3515F | 100 mg 500 mg 1 g 5 g 10 g 25 g 100 g | $45.00 $164.00 $200.00 $402.00 $575.00 $981.00 $2031.00 | 46 | |
Acts as a tyrosine kinase inhibitor, enhancing MA3 activity by modulating tyrosine kinase-dependent pathways. | ||||||
(±)-Bay K 8644 | 71145-03-4 | sc-203324 sc-203324A sc-203324B | 1 mg 5 mg 50 mg | $84.00 $196.00 $817.00 | ||
Activates L-type calcium channels, increasing intracellular calcium levels and enhancing MA3 activity when it functions in a calcium-dependent manner. | ||||||