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Topo I Antibody (C-21) is a mouse monoclonal IgM antibody that detects Topo I protein of mouse, rat, and human origin by western blotting (WB), immunoprecipitation (IP), immunofluorescence (IF), and immunohistochemistry. Anti-Topo I antibody (C-21) is available in both non-conjugated and various conjugated forms, including agarose, horseradish peroxidase (HRP), phycoerythrin (PE), fluorescein isothiocyanate (FITC), and multiple Alexa Fluor® conjugates. Topo I protein, also known as DNA topoisomerase I, plays a crucial role in maintaining DNA structure integrity during cellular processes such as replication, transcription, and recombination. By introducing a transient break in one strand of the DNA helix, Topo I alleviates torsional strain that arises ahead of the replication fork, preventing DNA supercoiling and ensuring proper DNA function. This enzymatic activity is vital for cellular health, as dysregulation of Topo I can lead to genomic instability and has been implicated in various cancers, making Topo I a significant target for anticancer therapies. Topo I interacts with several other proteins, including transcription factors and repair proteins, which further underscores Topo I′s importance in cellular processes and highlights Topo I′s potential as a therapeutic target.
Alexa Fluor® is a trademark of Molecular Probes Inc., OR., USA
LI-COR® and Odyssey® are registered trademarks of LI-COR Biosciences
Ordering Information
Product Name | Catalog # | UNIT | Price | Qty | FAVORITES | |
Topo I Antibody (C-21) | sc-32736 | 200 µg/ml | $316.00 | |||
Topo I Antibody (C-21): m-IgGκ BP-HRP Bundle | sc-520854 | 200 µg Ab, 40 µg BP | $354.00 | |||
Topo I Antibody (C-21) AC | sc-32736 AC | 500 µg/ml, 25% agarose | $416.00 | |||
Topo I Antibody (C-21) Alexa Fluor® 488 | sc-32736 AF488 | 200 µg/ml | $357.00 | |||
Topo I Antibody (C-21) Alexa Fluor® 647 | sc-32736 AF647 | 200 µg/ml | $357.00 | |||
Topo I Antibody (C-21) FITC | sc-32736 FITC | 200 µg/ml | $330.00 | |||
Topo I Antibody (C-21) HRP | sc-32736 HRP | 200 µg/ml | $316.00 | |||
Topo I Antibody (C-21) PE | sc-32736 PE | 200 µg/ml | $343.00 |