GABA Receptor Inhibitors
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Items 1 to 10 of 34 total
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| Product Name | CAS # | Catalog # | QUANTITY | Price | Citations | RATING |
|---|---|---|---|---|---|---|
(−)-Bicuculline methobromide | 73604-30-5 | sc-200436 | 50 mg | $315.00 | 3 | |
(-)-Bicuculline methobromide is a potent antagonist of GABA receptors, characterized by its ability to disrupt the binding of GABA to its receptor sites. This compound exhibits unique steric hindrance, which alters the receptor's conformational landscape, leading to a decrease in chloride ion conductance. Its distinct molecular structure allows for specific interactions with the receptor's allosteric sites, influencing downstream signaling pathways and modulating neuronal excitability. | ||||||
(−)-α-Thujone | 546-80-5 | sc-252342 | 1 ml | $74.00 | ||
(-)-α-Thujone acts as a GABA receptor modulator, exhibiting a unique ability to enhance receptor activity through specific binding interactions. Its molecular conformation allows it to stabilize the receptor in an active state, promoting increased chloride ion influx. This compound's hydrophobic regions facilitate interactions with lipid membranes, potentially influencing receptor localization and dynamics. Additionally, its kinetic profile suggests rapid onset and modulation of synaptic transmission, impacting neuronal signaling pathways. | ||||||
Pregnenolone | 145-13-1 | sc-204860 sc-204860A sc-204860B sc-204860C | 5 g 25 g 100 g 500 g | $85.00 $145.00 $340.00 $1100.00 | ||
Pregnenolone functions as a GABA receptor modulator, characterized by its capacity to selectively bind to receptor sites, thereby influencing neurotransmission. Its structural features enable it to interact with lipid bilayers, which may alter receptor conformation and enhance chloride ion permeability. The compound's unique interaction dynamics suggest a nuanced role in synaptic plasticity, potentially affecting the timing and strength of neuronal signaling cascades. | ||||||
NNC 711 | 145645-62-1 | sc-204132 sc-204132A | 5 mg 25 mg | $118.00 $307.00 | ||
NNC 711 acts as a GABA receptor antagonist, exhibiting a unique ability to disrupt the binding of endogenous ligands. Its molecular structure facilitates specific interactions with the receptor's allosteric sites, leading to altered ion channel kinetics. This modulation can influence the excitatory-inhibitory balance in neural circuits. Additionally, NNC 711's hydrophobic regions may enhance membrane penetration, impacting receptor localization and function within synaptic environments. | ||||||
CGP 54626 hydrochloride | 149184-21-4 | sc-361142 | 10 mg | $270.00 | ||
CGP 54626 hydrochloride functions as a selective GABA receptor modulator, characterized by its ability to stabilize receptor conformation. Its unique binding affinity allows it to influence the receptor's desensitization kinetics, thereby affecting neurotransmitter release dynamics. The compound's specific interactions with the receptor's transmembrane domains can alter ion permeability, potentially reshaping synaptic signaling pathways. Furthermore, its solubility properties may enhance its distribution in lipid-rich environments, impacting receptor accessibility. | ||||||
Flumazenil (Ro 15-1788) | 78755-81-4 | sc-200161 sc-200161A | 25 mg 100 mg | $108.00 $363.00 | 10 | |
Flumazenil acts as a competitive antagonist at the GABA receptor, exhibiting a unique ability to disrupt the binding of benzodiazepines. Its structural conformation allows for specific interactions with the receptor's allosteric sites, influencing the receptor's functional state. This modulation can lead to altered ion channel activity and neurotransmission. Additionally, its rapid kinetics facilitate swift receptor response, making it a notable player in the dynamics of GABAergic signaling. | ||||||
Picrotoxin | 124-87-8 | sc-202765 sc-202765A sc-202765B | 1 g 5 g 25 g | $66.00 $280.00 $1300.00 | 11 | |
Picrotoxin functions as a non-competitive antagonist at the GABA receptor, uniquely inhibiting chloride ion influx. Its distinct molecular structure allows it to bind to the receptor's channel, altering its conformation and disrupting normal inhibitory neurotransmission. This interference can lead to excitatory effects in neural pathways. Picrotoxin's interaction kinetics are characterized by a slower onset, contributing to prolonged alterations in synaptic activity and neuronal excitability. | ||||||
CGP 35348 | 123690-79-9 | sc-361138 sc-361138A | 10 mg 50 mg | $169.00 $681.00 | 1 | |
CGP 35348 acts as a selective antagonist at the GABA receptor, specifically targeting the GABA_B subtype. Its unique binding affinity alters receptor dynamics, leading to a decrease in potassium ion conductance. This modulation affects intracellular signaling pathways, particularly those involving cyclic AMP. The compound exhibits rapid kinetics, allowing for swift receptor interaction, which can significantly influence synaptic plasticity and neurotransmitter release mechanisms. | ||||||
SR 95531 Hydrobromide | 104104-50-9 | sc-203701 sc-203701A | 10 mg 50 mg | $154.00 $506.00 | 1 | |
SR 95531 Hydrobromide is a potent antagonist of the GABA_A receptor, exhibiting high specificity for the benzodiazepine site. Its unique molecular structure facilitates competitive inhibition, disrupting chloride ion influx and altering neuronal excitability. The compound's rapid association and dissociation kinetics enable precise modulation of synaptic transmission, influencing various neurophysiological processes. Additionally, its hydrobromide form enhances solubility, promoting effective receptor engagement. | ||||||
(+)-Bicuculline | 485-49-4 | sc-202498 sc-202498A | 50 mg 250 mg | $80.00 $275.00 | ||
(+)-Bicuculline is a selective antagonist of the GABA_A receptor, characterized by its ability to bind to the receptor's allosteric site. This binding alters the receptor's conformation, inhibiting chloride ion conductance and thereby modulating inhibitory neurotransmission. Its unique stereochemistry contributes to its distinct interaction profile, allowing for nuanced effects on synaptic plasticity. The compound's dynamic binding kinetics facilitate rapid changes in neuronal signaling, impacting various neural circuits. | ||||||