Molecular structure of Pregnenolone, CAS Number: 145-13-1
Pregnenolone (CAS 145-13-1)
Alternate Names:
Δ5-Pregenen-3β-ol-20-one; 3β-Hydroxy-5-pregenen-20-one; Arthenolone; Skinostelon; Enelone; Pregnetan; Pregneton; Pregnolon; Prenolon; Regnosone
Application:
Pregnenolone is an prohormone neurosteroid also a precursor to gonadal steroid hormones and the adrenal corticosteroids
CAS Number:
145-13-1
Molecular Weight:
316.48
Molecular Formula:
C21H32O2
For Research Use Only. Not Intended for Diagnostic or Therapeutic Use.
* Refer to Certificate of Analysis for lot specific data.
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SDS & Certificate of Analysis
Pregnenolone is an endogenous neurosteroid that is involved in the steroidogenesis of progesterone, glucocorticoids, mineralocorticoids, androgens, and estrogens, making it a prohormone. It has been observed to inhibit GABA-gated chloride currents by enhancing receptor desensitization. Pregnenolone is an inhibitor of GABA Receptor and an activator of PXR.
Pregnenolone (CAS 145-13-1) References
- Pregnenolone, pregnenolone sulfate, and cytochrome P450 side-chain cleavage enzyme in the amphibian brain and their seasonal changes. | Takase, M., et al. 1999. Endocrinology. 140: 1936-44. PMID: 10098534
- Pregnenolone protects mouse hippocampal (HT-22) cells against glutamate and amyloid beta protein toxicity. | Gursoy, E., et al. 2001. Neurochem Res. 26: 15-21. PMID: 11358277
- Memory-enhancing effects in male mice of pregnenolone and steroids metabolically derived from it. | Flood, JF., et al. 1992. Proc Natl Acad Sci U S A. 89: 1567-71. PMID: 1531874
- The effects of the neurosteroids: pregnenolone, progesterone and dehydroepiandrosterone on muscarinic receptor-induced responses in Xenopus oocytes expressing M1 and M3 receptors. | Horishita, T., et al. 2005. Naunyn Schmiedebergs Arch Pharmacol. 371: 221-8. PMID: 15900516
- Changes in cytochrome P450 side chain cleavage expression in the rat hippocampus after kainate injury. | Chia, WJ., et al. 2008. Exp Brain Res. 186: 143-9. PMID: 18040670
- Effect of complexes of apolipoprotein A-I with tetrahydrocortisol and pregnenolone on protein biosynthesis in rat hepatocytes culture. | Panin, LE., et al. 2007. Bull Exp Biol Med. 144: 291-3. PMID: 18457017
- Pregnenolone activates CLIP-170 to promote microtubule growth and cell migration. | Weng, JH., et al. 2013. Nat Chem Biol. 9: 636-42. PMID: 23955365
- Pregnenolone can protect the brain from cannabis intoxication. | Vallée, M., et al. 2014. Science. 343: 94-8. PMID: 24385629
- Measurement of Mitochondrial Cholesterol Import Using a Mitochondria-Targeted CYP11A1 Fusion Construct. | Kennedy, BE., et al. 2017. Methods Mol Biol. 1583: 163-184. PMID: 28205173
- Pregnenolone and pregnenolone-methyl-ether rescue neuronal defects caused by dysfunctional CLIP170 in a neuronal model of CDKL5 Deficiency Disorder. | Barbiero, I., et al. 2020. Neuropharmacology. 164: 107897. PMID: 31794725
- CRISPR-Cas9-Mutated Pregnane X Receptor (pxr) Retains Pregnenolone-induced Expression of cyp3a65 in Zebrafish (Danio rerio) Larvae. | Salanga, MC., et al. 2020. Toxicol Sci. 174: 51-62. PMID: 31868891
- Intracellular redistribution of SCP2 in Leydig cells after hormonal stimulation may contribute to increased pregnenolone production. | van Noort, M., et al. 1988. Biochem Biophys Res Commun. 154: 60-5. PMID: 3395346
- Determination of 19 Steroid Hormones in Human Serum and Urine Using Liquid Chromatography-Tandem Mass Spectrometry. | Li, ZM. and Kannan, K. 2022. Toxics. 10: PMID: 36422894
- Pregnenolone and its sulfate ester in the rat brain. | Corpéchot, C., et al. 1983. Brain Res. 270: 119-25. PMID: 6223687
- Pregnenolone and pregnenolone sulfate, alone and with ethanol, in mice on the plus-maze. | Melchior, CL. and Ritzmann, RF. 1994. Pharmacol Biochem Behav. 48: 893-7. PMID: 7972293
Inhibitor of:
GABA Receptor.Activator of:
17-β Estradiol, 17β-HSD14, 17β-HSD3, 1700019B21Rik, 3β-HSD, 3β-HSD3, 3β-HSD4, 3β-HSD5, AbdA, ABP, ACAT-2, ARA55, CYP21A2, CYP2R1, CYP39A1, DAF-12, EG545948, EG668526, Gliomedin, GPR10, GPR150, HES7, KQT2, MRAP, MUP15, Na+ CP type XIα, NCoA-5, NR3B, PBR, Peripherin, PGRMC1, PGRMC2, plexin-B1, PR, PXR, SRD5A2L2, SULT1E1, SULT2A2, SULT2B10, Svs4, TRPM3, UGT1A4, and VGLUT1.Ordering Information
| Product Name | Catalog # | UNIT | Price | Qty | FAVORITES | |
Pregnenolone, 5 g | sc-204860 | 5 g | $85.00 | |||
Pregnenolone, 25 g | sc-204860A | 25 g | $145.00 | |||
Pregnenolone, 100 g | sc-204860B | 100 g | $340.00 | |||
Pregnenolone, 500 g | sc-204860C | 500 g | $1100.00 |