Molecular structure of NNC 711, CAS Number: 145645-62-1
NNC 711 (CAS 145645-62-1)
Alternate Names:
NO-711 hydrochloride; 1,2,5,6-Tetrahydro-1-[2-[[(diphenylmethylene)amino]oxy] ethyl]-3-pyridinecarboxylic acid hydrochloride
Application:
NNC 711 is a potent and selective inhibitor of GABA T-1
CAS Number:
145645-62-1
Purity:
≥99%
Molecular Weight:
386.88
Molecular Formula:
C21H22N2O3•HCl
For Research Use Only. Not Intended for Diagnostic or Therapeutic Use.
* Refer to Certificate of Analysis for lot specific data.
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SDS & Certificate of Analysis
NNC 711 is a chemical compound that functions as a selective antagonist at the NMDA receptor glycine site. It acts by binding to the glycine site of the NMDA receptor, thereby inhibiting the binding of glycine and preventing the activation of the receptor. This results in the blockade of NMDA receptor-mediated neurotransmission, leading to the inhibition of excitatory synaptic transmission. By modulating the activity of the NMDA receptor, NNC 711 plays a role in regulating synaptic plasticity and neuronal excitability. Nnc 711′s mechanism of action involves interfering with the normal functioning of the NMDA receptor, which is involved in various physiological and pathological processes in the central nervous system.
NNC 711 (CAS 145645-62-1) References
- GABA uptake blocker NNC-711 exhibits marked anticonvulsant action in two cortical epileptic models in immature rats. | Bernásková, K., et al. 1999. Epilepsia. 40: 1184-9. PMID: 10487180
- Anti-ischemic and cognition-enhancing properties of NNC-711, a gamma-aminobutyric acid reuptake inhibitor. | O'Connell, AW., et al. 2001. Eur J Pharmacol. 424: 37-44. PMID: 11470258
- NNC-711, a novel potent and selective gamma-aminobutyric acid uptake inhibitor: pharmacological characterization. | Suzdak, PD., et al. 1992. Eur J Pharmacol. 224: 189-98. PMID: 1468507
- Participation of GABA-ergic system in epileptogenic activity induced by teicoplanin in mice. | Takechi, K., et al. 2009. Epilepsy Res. 84: 127-34. PMID: 19233620
- Anticonvulsant effect of (RS)-1-aminoindan-1,5-dicarboxylic acid on pentetrazol-induced kindled seizures in mice. | Watanabe, Y., et al. 2010. Biol Pharm Bull. 33: 647-52. PMID: 20410600
- Effects of pharmacological entopeduncular manipulations on idiopathic dystonia in the dt(sz) mutant hamster. | Hamann, M., et al. 2010. J Neural Transm (Vienna). 117: 747-57. PMID: 20454986
- GABA transporters control GABAergic neurotransmission in the mouse subplate. | Unichenko, P., et al. 2015. Neuroscience. 304: 217-27. PMID: 26232716
- GABA transporters regulate tonic and synaptic GABAA receptor-mediated currents in the suprachiasmatic nucleus neurons. | Moldavan, M., et al. 2017. J Neurophysiol. 118: 3092-3106. PMID: 28855287
- Microglial expression of GAT-1 in the cerebral cortex. | Fattorini, G., et al. 2020. Glia. 68: 646-655. PMID: 31692106
- Distinct synaptic mechanisms underlying the analgesic effects of γ-aminobutyric acid transporter subtypes 1 and 3 inhibitors in the spinal dorsal horn. | Oyama, M., et al. 2022. Pain. 163: 334-349. PMID: 33990107
- Tiagabine, SK&F 89976-A, CI-966, and NNC-711 are selective for the cloned GABA transporter GAT-1. | Borden, LA., et al. 1994. Eur J Pharmacol. 269: 219-24. PMID: 7851497
- Effect of a gamma-aminobutyric acid uptake inhibitor, NNC-711, on spontaneous postsynaptic currents in cultured rat hippocampal neurons: implications for antiepileptic drug development. | Oh, DJ. and Dichter, MA. 1994. Epilepsia. 35: 426-30. PMID: 8156968
- Comparative effects of the GABA uptake inhibitors, tiagabine and NNC-711, on extracellular GABA levels in the rat ventrolateral thalamus. | Richards, DA. and Bowery, NG. 1996. Neurochem Res. 21: 135-40. PMID: 9182238
Inhibitor of:
GABA Receptor, GABA T-1, Gat1, and Gephyrin.Activator of:
Shigatoxin 1.Ordering Information
| Product Name | Catalog # | UNIT | Price | Qty | FAVORITES | |
NNC 711, 5 mg | sc-204132 | 5 mg | $120.00 | |||
NNC 711, 25 mg | sc-204132A | 25 mg | $313.00 |