Molecular structure of (−)-Bicuculline methobromide, CAS Number: 73604-30-5
(−)-Bicuculline methobromide (CAS 73604-30-5)
See product citations (3)
Application:
(−)-Bicuculline methobromide is an N-methylated derivative of the GABAA antagonist bicuculline
CAS Number:
73604-30-5
Purity:
≥98%
Molecular Weight:
462.29
Molecular Formula:
C21H20BrNO6
Supplemental Information:
This is classified as a Dangerous Good for transport and may be subject to additional shipping charges.
For Research Use Only. Not Intended for Diagnostic or Therapeutic Use.
* Refer to Certificate of Analysis for lot specific data.
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SDS & Certificate of Analysis
(−)-Bicuculline methobromide is the N-methyl methobromide salt of bicuculline, a competitive antagonist of the GABAA receptor. The N-methyl derivatives (−)-Bicuculline methobromide and (−)-Bicuculline methiodide (sc-200485) are more water-soluble and stable than the parent compound and have been employed as specific GABAA receptor antagonists analogous in function to the free base of bicuculline. Non-GABAA-specific behavior divergent from the activity of the parent compound has been reported with (−)-Bicuculline methobromide and (−)-Bicuculline methiodide. Both compounds are observed to block afterhyperpolarizations mediated by Ca2+-activated K+ channels in dopaminergic neurons.
(−)-Bicuculline methobromide (CAS 73604-30-5) References
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- Sympathoexcitation by PVN-injected bicuculline requires activation of excitatory amino acid receptors. | Chen, QH., et al. 2003. Hypertension. 42: 725-31. PMID: 12900439
- The antiallodynic effect of Neurotropin is mediated via activation of descending pain inhibitory systems in rats with spinal nerve ligation. | Okazaki, R., et al. 2008. Anesth Analg. 107: 1064-9. PMID: 18713930
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- On the GABAA receptor: a molecular modeling approach. | Aprison, MH. and Lipkowitz, KB. 1989. J Neurosci Res. 23: 129-35. PMID: 2547082
- Modulation of acetylcholine release from rat striatal slices by the GABA/benzodiazepine receptor complex. | Supavilai, P. and Karobath, M. 1985. Life Sci. 36: 417-26. PMID: 2982067
- Nigral infusions of muscimol or bicuculline facilitate seizures in developing rats. | Sperber, EF., et al. 1987. Brain Res. 465: 243-50. PMID: 3440204
- 3H-baclofen and 3H-GABA bind to bicuculline-insensitive GABA B sites in rat brain. | Hill, DR. and Bowery, NG. 1981. Nature. 290: 149-52. PMID: 6259535
- Further characterization of the anorexic action of orally-administered THIP, a GABA-analogue, in the rat. | Blavet, N. and DeFeudis, FV. 1982. Physiol Behav. 29: 901-4. PMID: 6296893
- Spinal effects of bicuculline: modulation of an allodynia-like state by an A1-receptor agonist, morphine, and an NMDA-receptor antagonist. | Reeve, AJ., et al. 1998. J Neurophysiol. 79: 1494-507. PMID: 9497427
Inhibitor of:
GABA Receptor.Ordering Information
| Product Name | Catalog # | UNIT | Price | Qty | FAVORITES | |
(−)-Bicuculline methobromide, 50 mg | sc-200436 | 50 mg | $450.00 |