Molecular structure of (+)-Bicuculline, CAS Number: 485-49-4
(+)-Bicuculline (CAS 485-49-4)
Alternate Names:
(+)-Bicuculline; d-Bicuculline; Bicculine; Bicucullin; Bicuculline (+)
Application:
(+)-Bicuculline is a GABA A receptor antagonist
CAS Number:
485-49-4
Purity:
>98%
Molecular Weight:
367.35
Molecular Formula:
C20H17NO6
Supplemental Information:
This is classified as a Dangerous Good for transport and may be subject to additional shipping charges.
For Research Use Only. Not Intended for Diagnostic or Therapeutic Use.
* Refer to Certificate of Analysis for lot specific data.
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SDS & Certificate of Analysis
(+)-Bicuculline is an antagonist of the GABAA receptor. (+)-Bicuculline is the parent compound of the water soluble N-methyl derivatives (−)-Bicuculline methiodide (sc-200485) and (−)-Bicuculline methobromide (sc-200436). Antagonism of the GABAA receptor by (+)-Bicuculline blocks the neurotransmission inhibition function of the GABA system in vitro.
(+)-Bicuculline (CAS 485-49-4) References
- Cardiovascular effects of intracerebroventricular bicuculline in rats with absence seizures. | Karson, AB., et al. 1999. Epilepsy Res. 34: 231-9. PMID: 10210038
- Bicuculline increases Ca2+ transients in rat cerebellar granule cells through non-GABA(A) receptor associated mechanisms. | Mestdagh, N. and Wülfert, E. 1999. Neurosci Lett. 265: 95-8. PMID: 10327177
- The 'ABC' of GABA receptors: a brief review. | Chebib, M. and Johnston, GA. 1999. Clin Exp Pharmacol Physiol. 26: 937-40. PMID: 10561820
- Bicuculline administration into ventromedial hypothalamus: effects on fear and regional brain monoamines and GABA concentrations in rats. | Zagrodzka, J., et al. 2000. Acta Neurobiol Exp (Wars). 60: 333-43. PMID: 11016075
- Convulsant action of systemically administered glutamate and bicuculline methiodide in immature rats. | Mares, P., et al. 2000. Epilepsy Res. 42: 183-9. PMID: 11074190
- Bicuculline infusion into the accessory olfactory bulb facilitates the induction of maternal behavior in rats. | Carretero, MI., et al. 2003. Scand J Psychol. 44: 273-7. PMID: 12914591
- Bicuculline free base blocks voltage-activated K+ currents in rat medial preoptic neurons. | Druzin, M., et al. 2004. Neuropharmacology. 46: 285-95. PMID: 14680766
- Cannabinoid suppressed bicuculline-induced convulsion without respiratory depression in the brainstem-spinal cord preparation from newborn rats. | Koda, S., et al. 2005. Biomed Res. 26: 241-7. PMID: 16415505
- Convulsant bicuculline modifies CNS muscarinic receptor affinity. | Schneider, PG. and Rodríguez de Lores Arnaiz, G. 2006. BMC Neurosci. 7: 32. PMID: 16615872
- Synaptic NMDA receptor activation stimulates alpha-secretase amyloid precursor protein processing and inhibits amyloid-beta production. | Hoey, SE., et al. 2009. J Neurosci. 29: 4442-60. PMID: 19357271
- Antagonistic properties of a natural product-Bicuculline with the gamma-aminobutyric acid receptor: studied through electrostatic potential mapping, electronic and vibrational spectra using ab initio and density functional theory. | Srivastava, A., et al. 2011. Spectrochim Acta A Mol Biomol Spectrosc. 84: 144-55. PMID: 21968210
- Coadministration of bicuculline and NMDA induces paraplegia in the rat. | Ionov, ID. and Roslavtseva, LA. 2012. Brain Res. 1451: 27-33. PMID: 22445063
- GABA, bicuculline and central inhibition. | Curtis, DR., et al. 1970. Nature. 226: 1222-4. PMID: 4393081
- Bicuculline infusion advances the timing of Fos expression in LHRH neurons in the preoptic area of proestrous rats. | Funabashi, T., et al. 1997. Neuroreport. 8: 771-4. PMID: 9106764
- Functional and pharmacological properties of GABA-mediated inhibition in the human neocortex. | Avoli, M., et al. 1997. Can J Physiol Pharmacol. 75: 526-34. PMID: 9250388
Inhibitor of:
ArgRS, B830028B13Rik, Blue-Sensitive Opsin, C8orf68, Cerebellin 1, Cerebellin 4, dendrin, Gab 1, GABA Receptor, GABAA θ, GABAA 3, GABAA R rho 1, GABAA Rα2, GABAA Rα3, GABAA Rα4, GABAA Rα5, GABAA Rβ1, GABAA Rβ3, GABAA Rδ, GABAA Rε, GABAA Rγ2, GABAA Rγ3, GABAA Rγ4, GABAA Rπ, GABAA Rρ2, GABAA Rρ3, GABAA Rθ, GABAA Rp, GABAC Rρ1, GABAC Rρ2, GABAC Rρ3, Gephyrin, GlyR α1 (GLRA1), GlyR α3, KIAA0319L_AU040320, Latrophilin (ADGRL), Latrophilin-1, Latrophilin-2, LRRTM4, Mover, neurexin II, neuroligin 3, NP60, Olfr1104, Olfr319, Olfr320, Olfr331, Olfr358, OR4D9, PSD2, SAPAP4, SHISA6, SLITRK6, SYCE3, SYNDIG1, TMEM132E, V1RA1, V1rg10, Vmn2r106, Vmn2r107, Vmn2r110, Vmn2r122, Vmn2r31, Vmn2r32, Vmn2r33, Vmn2r43, Vmn2r48, Vmn2r49, Vmn2r51, Vmn2r56, Vmn2r61, Vmn2r67, Vmn2r79, and Vmn2r94.Activator of:
CA XV, CNIH4, DARPP-32, GABA T-1, GABA T-2, GABA T-3, GABAA θ, GABAA Rβ1, GABAA Rρ2, GABAA Rρ3, GRIF-1, KCNC4, KCTD4, KV3.1, LRFN3, MBLAC2, MrgA3, neuroligin 2, neuroligin X, NMUR1, NP2, Olfr1095, PREP, PRRT1, SHISA9, STOP, TDAG8, and VAChT.Ordering Information
| Product Name | Catalog # | UNIT | Price | Qty | FAVORITES | |
(+)-Bicuculline, 50 mg | sc-202498 | 50 mg | $82.00 | |||
(+)-Bicuculline, 250 mg | sc-202498A | 250 mg | $281.00 |