caspase-9 Antibody (10.1.87): sc-81650

caspase-9 Antibody (10.1.87) is a mouse monoclonal IgG1 antibody that detects caspase-9 in mouse, rat, and human samples through applications such as western blotting (WB) and immunoprecipitation (IP). Caspase-9 plays a pivotal role in the intrinsic pathway of apoptosis, acting as an initiator caspase that is activated in response to cellular stress and damage. Upon activation, caspase-9 cleaves and activates downstream effector caspases, such as caspase-3 and caspase-7, leading to the execution phase of apoptosis. This process is crucial for maintaining cellular homeostasis and eliminating damaged or unwanted cells, thereby preventing the development of various diseases, including cancer. The activation of caspase-9 is tightly regulated and can be influenced by various factors, including post-translational modifications such as phosphorylation and ubiquitination, which can affect its activity and stability. Anti-caspase-9 antibody (10.1.87) enables researchers to gain valuable insights into the mechanisms of apoptosis and the role of caspase-9 in various biological processes and disease states.

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caspase-9 Antibody (10.1.87) References:

1. Activation of caspase-9 is required for UV-induced apoptosis of human keratinocytes.  |  Sitailo, LA., et al. 2002. J Biol Chem. 277: 19346-52. PMID: 11919192
2. Caspase-9 can antagonize p53-induced apoptosis by generating a p76(Rb) truncated form of Rb.  |  Lemaire, C., et al. 2005. Oncogene. 24: 3297-308. PMID: 15735701
3. Loss of caspase-9 reveals its essential role for caspase-2 activation and mitochondrial membrane depolarization.  |  Samraj, AK., et al. 2007. Mol Biol Cell. 18: 84-93. PMID: 17079734
4. Caspase-9 expression is increased in endothelial cells of active Behçet's disease patients.  |  Oztaş, P., et al. 2007. Int J Dermatol. 46: 172-6. PMID: 17269970
5. Phosphorylation of murine caspase-9 by the protein kinase casein kinase 2 regulates its cleavage by caspase-8.  |  McDonnell, MA., et al. 2008. J Biol Chem. 283: 20149-58. PMID: 18467326
6. A non-apoptotic role for caspase-9 in muscle differentiation.  |  Murray, TV., et al. 2008. J Cell Sci. 121: 3786-93. PMID: 18957517
7. Inhibition of caspase-9 by oridonin, a diterpenoid isolated from Rabdosia rubescens, augments apoptosis in human laryngeal cancer cells.  |  Kang, N., et al. 2015. Int J Oncol. 47: 2045-56. PMID: 26648189
8. Investigation of Caspase 9 Gene Polymorphism in Patients With Non-small Cell Lung Cancer.  |  Ercan, S., et al. 2019. Anticancer Res. 39: 2437-2441. PMID: 31092436
9. Aloe-Emodin Induces Mitochondrial Dysfunction and Pyroptosis by Activation of the Caspase-9/3/Gasdermin E Axis in HeLa Cells.  |  Li, T., et al. 2022. Front Pharmacol. 13: 854526. PMID: 35662735
10. DiaPASEF proteotype analysis indicates changes in cell growth and metabolic switch induced by caspase-9 inhibition in chondrogenic cells.  |  Lapcik, P., et al. 2023. Proteomics. 23: e2200408. PMID: 36960851

The preferred caspase-9 antibody is caspase-9 Antibody (96.1.23): sc-56076.