caspase-8 Antibody (8CSP02): sc-81662

caspase-8 Antibody (8CSP02) is a mouse monoclonal IgG1 antibody that detects caspase-8 in mouse, rat, and human samples through applications such as western blotting (WB) and immunoprecipitation (IP). Caspase-8 plays a crucial role in the apoptotic signaling pathway, acting as the most upstream protease in the activation cascade triggered by tumor necrosis factor receptor superfamily members, such as TNFRSF1A and TNFRSF6/FAS. Upon activation, caspase-8 cleaves and activates downstream effector caspases, leading to the execution of apoptosis, a vital process for maintaining cellular homeostasis and eliminating damaged or unwanted cells. Caspase-8 is primarily located in the cytoplasm, where caspase-8 forms a complex with the adaptor molecule FADD, creating the death-inducing signaling complex (DISC) that is essential for activation. This localization allows rapid response to apoptotic signals, ensuring timely cell death in response to various stimuli. Additionally, defects in the CASP8 gene, which encodes for caspase-8, can lead to caspase-8 deficiency disorder (CASP8D), a condition characterized by splenomegaly and impaired apoptosis of peripheral blood leukocytes, ultimately resulting in immunodeficiency due to compromised activation of T lymphocytes, natural killer cells, and B lymphocytes. Anti-caspase-8 antibody (8CSP02) is an invaluable tool for researchers studying apoptosis and its implications in various diseases, including cancer and autoimmune disorders.

The preferred caspase-8 p18 antibody is caspase-8 p18 Antibody (D-8): sc-5263.