caspase-8 Antibody (8CSP01): sc-81661

caspase-8 Antibody (8CSP01) is a mouse monoclonal IgG1 antibody that detects caspase-8 in mouse, rat, and human samples through applications such as western blotting (WB) and immunoprecipitation (IP). Caspase-8 plays a crucial role in the apoptotic signaling pathway, acting as the most upstream protease in the activation cascade triggered by tumor necrosis factor receptor superfamily members, including TNFRSF1A and TNFRSF6/FAS. Anti-caspase-8 antibody (8CSP01) is essential for studying apoptosis initiation, as caspase-8 cleaves and activates downstream effector caspases, thereby facilitating programmed cell death, which is vital for maintaining cellular homeostasis and immune system regulation. Caspase-8 is a heterodimer composed of two subunits, p18 and p10, and is predominantly expressed in peripheral blood leukocytes, thymus, liver, and spleen, highlighting its importance in immune responses. Notably, defects in the CASP8 gene, which encodes for caspase-8, can lead to caspase-8 deficiency disorder (CASP8D), a condition characterized by splenomegaly and impaired apoptosis of peripheral blood leukocytes, potentially resulting in severe immunodeficiency due to compromised activation of T lymphocytes, natural killer cells, and B lymphocytes. Caspase-8 monoclonal antibody (8CSP01) is an invaluable tool for researchers studying apoptosis and its implications in various diseases, including cancer and autoimmune disorders.

The preferred caspase-8 p18 antibody is caspase-8 p18 Antibody (D-8): sc-5263.