Date published: 2026-7-21

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IP3R Antibodies

Santa Cruz Biotechnology features a diverse variety of IP3R monoclonal antibodies for advanced research in cellular signaling pathways. IP3R Antibodies are validated for western blotting (WB), immunoprecipitation (IP), immunofluorescence (IF), immunohistochemistry with paraffin-embedded sections (IHCP), flow cytometry (FCM), and enzyme-linked immunosorbent assay (ELISA). Inositol trisphosphate receptors (IP3Rs) play a crucial role in calcium signaling by mediating the release of calcium ions from the endoplasmic reticulum in response to inositol trisphosphate. This calcium release is essential for numerous cellular processes, including muscle contraction, neurotransmitter release, and cell proliferation. Understanding IP3Rs is vital for elucidating their involvement in various physiological and pathological conditions, including cardiac function and neurodegenerative diseases. IP3R monoclonal antibodies enable researchers to investigate calcium signaling mechanisms across multiple experimental approaches. Studying IP3Rs contributes significantly to understanding cellular communication and regulation. Research utilizing IP3R monoclonal antibodies helps advance knowledge of disease mechanisms and potential therapeutic targets. Santa Cruz Biotechnology monoclonal antibodies support researchers worldwide in advancing scientific understanding of cellular signaling pathways and their impact on human health.

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IP3R Antibodies

Empty Table HeaderProduct NameCATALOG #ISOTYPEEPITOPEAPPLICATIONSSpeciesCitationsRATING

IP3R-I Antibody (E-8)

sc-271197mouse IgG1 κ1894-1973 (h)WB, IP, IF, IHC(P), ELISAm, r, h
24
(9)

IP3R-I/II/III Antibody (B-2)

sc-377518mouse IgG2b2402-2701 (h)WB, IP, IF, IHC(P), ELISAm, r, h
26
(13)

IP3R-II Antibody (A-5)

sc-398434mouse IgG2b κ2666-2695 (h)WB, IP, IF, ELISAm, r, h
25
(11)

IP3R siRNA, shRNA Plasmid and shRNA Lentiviral Particle Gene Silencers

Empty Table HeaderProduct NameCATALOG #SpeciesAPPLICATIONSMARKERCitationsRATING

IP3R-I siRNA (h)

sc-42475hGene SilencingN/A
6
(1)

IP3R-I shRNA Plasmid (h)

sc-42475-SHhGene SilencingPuromycin
6
(1)

IP3R-I shRNA (h) Lentiviral Particles

sc-42475-VhGene SilencingPuromycin
6
(1)

IP3R-I siRNA (m)

sc-42476mGene SilencingN/A
3
(0)

IP3R-I shRNA Plasmid (m)

sc-42476-SHmGene SilencingPuromycin
3
(0)

IP3R-I shRNA (m) Lentiviral Particles

sc-42476-VmGene SilencingPuromycin
3
(0)

IP3R-II siRNA (h)

sc-35698hGene SilencingN/A
2
(0)

IP3R-II shRNA Plasmid (h)

sc-35698-SHhGene SilencingPuromycin
2
(0)

IP3R-II shRNA (h) Lentiviral Particles

sc-35698-VhGene SilencingPuromycin
2
(0)

IP3R-II siRNA (m)

sc-35699mGene SilencingN/A0
(0)

IP3R-II shRNA Plasmid (m)

sc-35699-SHmGene SilencingPuromycin0
(0)

IP3R-II shRNA (m) Lentiviral Particles

sc-35699-VmGene SilencingPuromycin0
(0)

IP3R-III siRNA (h)

sc-42477hGene SilencingN/A
1
(0)

IP3R-III shRNA Plasmid (h)

sc-42477-SHhGene SilencingPuromycin
1
(0)

IP3R-III shRNA (h) Lentiviral Particles

sc-42477-VhGene SilencingPuromycin
1
(0)

IP3R-III siRNA (m)

sc-42478mGene SilencingN/A0
(0)

IP3R-III shRNA Plasmid (m)

sc-42478-SHmGene SilencingPuromycin0
(0)

IP3R-III shRNA (m) Lentiviral Particles

sc-42478-VmGene SilencingPuromycin0
(0)

IP3R CRISPR Knockout (KO) and HDR Plasmids

Empty Table HeaderProduct NameCATALOG #APPLICATIONSSpeciesCitationsRATING

IP3R-I CRISPR/Cas9 KO Plasmid (h)

sc-400986Gene Knockouth0
(0)

IP3R-I CRISPR/Cas9 KO Plasmid (m)

sc-421192Gene Knockoutm0
(0)

IP3R-II CRISPR/Cas9 KO Plasmid (h2)

sc-401067-KO-2Gene Knockouth0
(0)

IP3R-II HDR Plasmid (h2)

sc-401067-HDR-2Homology Directed Repairh0
(0)

IP3R-III CRISPR/Cas9 KO Plasmid (h)

sc-402138Gene Knockouth0
(0)

IP3R-III HDR Plasmid (h)

sc-402138-HDRHomology Directed Repairh0
(0)

IP3R CRISPR Double Nickase Plasmids

Empty Table HeaderProduct NameCATALOG #APPLICATIONSSpeciesCitationsRATING

IP3R-I Double Nickase Plasmid (h)

sc-400986-NICGene Knockouth0
(0)

IP3R-I Double Nickase Plasmid (h2)

sc-400986-NIC-2Gene Knockouth0
(0)

IP3R-II Double Nickase Plasmid (h)

sc-401067-NICGene Knockouth0
(0)

IP3R-II Double Nickase Plasmid (h2)

sc-401067-NIC-2Gene Knockouth0
(0)

IP3R-III Double Nickase Plasmid (h)

sc-402138-NICGene Knockouth0
(0)

IP3R-III Double Nickase Plasmid (h2)

sc-402138-NIC-2Gene Knockouth0
(0)

IP3R CRISPR Activation Plasmids and Lentiviral Particles

Empty Table HeaderProduct NameCATALOG #APPLICATIONSSpeciesCitationsRATING

IP3R-I CRISPR Activation Plasmid (h)

sc-400986-ACTGene Activationh0
(0)

IP3R-I Lentiviral Activation Particles (h)

sc-400986-LACGene Activationh0
(0)

IP3R-I CRISPR Activation Plasmid (m)

sc-421192-ACTGene Activationm0
(0)

IP3R-I CRISPR Activation Plasmid (m2)

sc-421192-ACT-2Gene Activationm0
(0)

IP3R-I Lentiviral Activation Particles (m)

sc-421192-LACGene Activationm0
(0)

IP3R-II CRISPR Activation Plasmid (h)

sc-401067-ACTGene Activationh0
(0)

IP3R-II CRISPR Activation Plasmid (m)

sc-421193-ACTGene Activationm0
(0)

IP3R-II CRISPR Activation Plasmid (m2)

sc-421193-ACT-2Gene Activationm0
(0)

IP3R-II Lentiviral Activation Particles (m)

sc-421193-LACGene Activationm0
(0)

IP3R-III CRISPR Activation Plasmid (h)

sc-402138-ACTGene Activationh0
(0)

IP3R-III CRISPR Activation Plasmid (m)

sc-421194-ACTGene Activationm0
(0)

IP3R-III Lentiviral Activation Particles (m)

sc-421194-LACGene Activationm0
(0)