IP3R-II Antibody (A-5): sc-398434

IP3R-II Antibody (A-5) is a mouse monoclonal IgG2b kappa light chain antibody that detects IP3R-II in mouse, rat, and human samples through applications such as western blotting (WB), immunoprecipitation (IP), immunofluorescence (IF), and enzyme-linked immunosorbent assay (ELISA). Anti-IP3R-II antibody (A-5) is available in both non-conjugated and various conjugated forms, including agarose, horseradish peroxidase (HRP), phycoerythrin (PE), fluorescein isothiocyanate (FITC), and multiple Alexa Fluor® conjugates. The inositol 1,4,5-triphosphate receptor, IP3R, plays a crucial role in cellular signaling by acting as a calcium release channel that is gated by inositol triphosphate (IP3). This mechanism is vital for numerous physiological processes, including muscle contraction, neurotransmitter release, and cell proliferation. IP3R-II is predominantly expressed in the brain and is involved in modulating synaptic plasticity and memory formation. Understanding IP3R-II function is essential for elucidating its role in various neurological disorders and for developing targeted therapies.

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IP3R-II Antibody (A-5) References:

1. Disruption of IP₃R2-mediated Ca²⁺ signaling pathway in astrocytes ameliorates neuronal death and brain damage while reducing behavioral deficits after focal ischemic stroke.  |  Li, H., et al. 2015. Cell Calcium. 58: 565-76. PMID: 26433454
2. Nonenzymatic function of DPP4 promotes diabetes-associated cognitive dysfunction through IGF-2R/PKA/SP1/ERp29/IP3R2 pathway-mediated impairment of Treg function and M1 microglia polarization.  |  Hui, Y., et al. 2023. Metabolism. 138: 155340. PMID: 36302455
3. IP3R2-mediated Ca2+ release promotes LPS-induced cardiomyocyte pyroptosis via the activation of NLRP3/Caspase-1/GSDMD pathway.  |  Wu, QR., et al. 2024. Cell Death Discov. 10: 91. PMID: 38378646
4. IP3R2 regulates apoptosis by Ca2+ transfer through mitochondria-ER contacts in hypoxic photoreceptor injury.  |  Xu, L., et al. 2024. Exp Eye Res. 245: 109965. PMID: 38851477
5. In situ hybridization of mRNA expression for IP3 receptor and IP3-3-kinase in rat brain after transient focal cerebral ischemia.  |  Zhang, SX., et al. 1995. Brain Res Mol Brain Res. 32: 252-60. PMID: 7500836
6. The inositol 1,4,5-triphosphate receptor expression in Drosophila suggests a role for IP3 signalling in muscle development and adult chemosensory functions.  |  Raghu, P. and Hasan, G. 1995. Dev Biol. 171: 564-77. PMID: 7556937
7. Heteroligomers of type-I and type-III inositol trisphosphate receptors in WB rat liver epithelial cells.  |  Joseph, SK., et al. 1995. J Biol Chem. 270: 23310-6. PMID: 7559486
8. Sequence and functional characterization of a third inositol trisphosphate receptor subtype, IP3R-3, expressed in pancreatic islets, kidney, gastrointestinal tract, and other tissues.  |  Blondel, O., et al. 1993. J Biol Chem. 268: 11356-63. PMID: 8388391
9. Calcineurin associated with the inositol 1,4,5-trisphosphate receptor-FKBP12 complex modulates Ca2+ flux.  |  Cameron, AM., et al. 1995. Cell. 83: 463-72. PMID: 8521476
10. Ataxia and epileptic seizures in mice lacking type 1 inositol 1,4,5-trisphosphate receptor.  |  Matsumoto, M., et al. 1996. Nature. 379: 168-71. PMID: 8538767
11. Regulation of the inositol 1,4,5-trisphosphate receptor by tyrosine phosphorylation.  |  Jayaraman, T., et al. 1996. Science. 272: 1492-4. PMID: 8633244
12. Lymphocyte apoptosis: mediation by increased type 3 inositol 1,4,5-trisphosphate receptor.  |  Khan, AA., et al. 1996. Science. 273: 503-7. PMID: 8662540

Monoclonal antibodies for mammalian and non-mammalian protein targets represent essentially all targets covered by polyclonal antibodies. Over 8,300 of our antibodies are offered as ImmunoCruz^® conjugates which eliminates the need for a secondary antibody.

Santa Cruz Biotechnology antibodies have over 360,000 research citations. Anti-IP3R-II Antibody (A-5) has 25 citations in a variety of scientific publications.

Primary antibodies like Anti-IP3R-II Antibody (A-5) for mammalian target proteins are recommended for the detection of a range of mammalian species, primarily of mouse, rat and human species. Many mammalian antibodies are also ideal for veterinary research and reactive with ovine, porcine, caprine, feline, canine, bovine and equine protein targets. Santa Cruz Biotechnology primary monoclonal antibodies are suitable for laboratory research applications and are not intended for diagnostic or therapeutic use.

IP3R-II Antibody (A-5) Specifications

Alternate Product Name: ITPR2

Product Clone Name: A-5

Classification: Primary Antibody

Clonality: Monoclonal Antibody

Antibody Isotype: IgG_2b kappa light chain

Amino Acids: 2666-2695

Epitope Target: IP3R-II

Epitope Species: human

Product Reactivity/Detection: IP3R-II

Species Reactivity/Detection: mouse, rat, human

Additional Mammalian Reactivity: equine, canine, bovine, porcine and avian

Additional Non-Mammalian Reactivity: N/A

Applications: WB, IP, IF, ELISA

Vialing Information: Each vial contains 200 µg IgG_2b kappa light chain in 1.0 ml of PBS with < 0.1% sodium azide and 0.1% gelatin

Research Citations: 25 citations in various scientific publications

Available Conjugates/Forms for IP3R-II Antibody (A-5): AC: Agarose, AF488: Alexa Fluor^® 488, AF546: Alexa Fluor^® 546, AF594: Alexa Fluor^® 594, AF647: Alexa Fluor^® 647, AF680: Alexa Fluor^® 680, AF790: Alexa Fluor^® 790, FITC: Fluoroscein, HRP: Horseradish Peroxidase, P: Blocking Peptide, PE: Phycoerythrin

The preferred IP3R-I/II/III antibody is IP3R-I/II/III Antibody (B-2): sc-377518.