Date published: 2026-4-24

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TNFα-IP 8L3 Activators

The chemical class of TNFα-IP 8L3 activators encompasses a diverse range of compounds that can modulate the activity of the protein TNFα-IP 8L3 through their influence on various cellular signaling pathways. The primary mechanism by which these activators operate involves the modulation of the NF-κB pathway, a central regulator of inflammation and immune responses within the cell. By interacting with this pathway, these chemicals can induce changes in the expression levels of TNFα-IP 8L3, thereby affecting its activity. Although the exact mechanisms of action for each chemical may vary, the overall effect is to alter the regulatory functions of TNFα-IP 8L3, which include the control of apoptosis, inflammation, and immune cell function.

These activators are characterized by their ability to engage with intracellular processes that are upstream of TNFα-IP 8L3, thereby initiating a cascade of events that lead to changes in the protein's expression or activity. The modulation of NF-κB by these activators can result in an upregulation of TNFα-IP 8L3, which in turn can have various consequences on cellular behavior. This class of chemicals can include molecules that either inhibit or activate components of the NF-κB pathway, resulting in alterations in the transcriptional activity of genes under the control of this pathway, including those encoding TNFα-IP 8L3. The ability to modulate such a critical pathway illustrates the significant role these chemicals can play in the regulation of TNFα-IP 8L3 and its associated cellular functions.

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Items 1 to 10 of 12 total

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Product NameCAS #Catalog #QUANTITYPriceCitationsRATING

Sulfasalazine

599-79-1sc-204312
sc-204312A
sc-204312B
sc-204312C
1 g
2.5 g
5 g
10 g
$61.00
$77.00
$128.00
$209.00
8
(1)

Inhibits NF-κB, which could possibly activate TNFAIP8L3 as a compensatory response in the inflammatory pathway.

Parthenolide

20554-84-1sc-3523
sc-3523A
50 mg
250 mg
$81.00
$306.00
32
(2)

Targets NF-κB signaling, which could influence TNFAIP8L3 expression due to its role in inflammation.

Withaferin A

5119-48-2sc-200381
sc-200381A
sc-200381B
sc-200381C
1 mg
10 mg
100 mg
1 g
$130.00
$583.00
$4172.00
$20506.00
20
(1)

Known to inhibit NF-κB activation, which could lead to alterations in TNFAIP8L3 levels as part of immune regulation.

BAY 11-7082

19542-67-7sc-200615B
sc-200615
sc-200615A
5 mg
10 mg
50 mg
$62.00
$85.00
$356.00
155
(1)

NF-κB inhibitor that could modulate TNFAIP8L3 expression through the inflammatory response pathway.

Curcumin

458-37-7sc-200509
sc-200509A
sc-200509B
sc-200509C
sc-200509D
sc-200509F
sc-200509E
1 g
5 g
25 g
100 g
250 g
1 kg
2.5 kg
$37.00
$69.00
$109.00
$218.00
$239.00
$879.00
$1968.00
47
(1)

Modulates NF-κB activity, potentially influencing TNFAIP8L3 expression in the context of inflammation and apoptosis.

Resveratrol

501-36-0sc-200808
sc-200808A
sc-200808B
100 mg
500 mg
5 g
$80.00
$220.00
$460.00
64
(2)

Affects NF-κB pathway, which could alter the expression of TNFAIP8L3 in immune and stress responses.

Piperlongumine

20069-09-4sc-364128
10 mg
$107.00
(1)

Interacts with NF-κB signaling, which could impact TNFAIP8L3's role in cell survival and apoptosis.

Emodin

518-82-1sc-202601
sc-202601A
sc-202601B
50 mg
250 mg
15 g
$105.00
$214.00
$6255.00
2
(1)

Has been shown to inhibit NF-κB, which could contribute to the modulation of TNFAIP8L3 activity in inflammation and cancer.

Quercetin

117-39-5sc-206089
sc-206089A
sc-206089E
sc-206089C
sc-206089D
sc-206089B
100 mg
500 mg
100 g
250 g
1 kg
25 g
$11.00
$17.00
$110.00
$250.00
$936.00
$50.00
33
(2)

Influences NF-κB signaling, which could lead to an effect on TNFAIP8L3 expression in immune cells.

(−)-Epigallocatechin Gallate

989-51-5sc-200802
sc-200802A
sc-200802B
sc-200802C
sc-200802D
sc-200802E
10 mg
50 mg
100 mg
500 mg
1 g
10 g
$43.00
$73.00
$126.00
$243.00
$530.00
$1259.00
11
(1)

A green tea polyphenol that modulates NF-κB, possibly affecting TNFAIP8L3 expression as part of its anti-inflammatory effects.