The chemical class of TNFα-IP 8L3 activators encompasses a diverse range of compounds that can modulate the activity of the protein TNFα-IP 8L3 through their influence on various cellular signaling pathways. The primary mechanism by which these activators operate involves the modulation of the NF-κB pathway, a central regulator of inflammation and immune responses within the cell. By interacting with this pathway, these chemicals can induce changes in the expression levels of TNFα-IP 8L3, thereby affecting its activity. Although the exact mechanisms of action for each chemical may vary, the overall effect is to alter the regulatory functions of TNFα-IP 8L3, which include the control of apoptosis, inflammation, and immune cell function.
These activators are characterized by their ability to engage with intracellular processes that are upstream of TNFα-IP 8L3, thereby initiating a cascade of events that lead to changes in the protein's expression or activity. The modulation of NF-κB by these activators can result in an upregulation of TNFα-IP 8L3, which in turn can have various consequences on cellular behavior. This class of chemicals can include molecules that either inhibit or activate components of the NF-κB pathway, resulting in alterations in the transcriptional activity of genes under the control of this pathway, including those encoding TNFα-IP 8L3. The ability to modulate such a critical pathway illustrates the significant role these chemicals can play in the regulation of TNFα-IP 8L3 and its associated cellular functions.
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| Product Name | CAS # | Catalog # | QUANTITY | Price | Citations | RATING |
|---|---|---|---|---|---|---|
Sulfasalazine | 599-79-1 | sc-204312 sc-204312A sc-204312B sc-204312C | 1 g 2.5 g 5 g 10 g | $61.00 $77.00 $128.00 $209.00 | 8 | |
Inhibits NF-κB, which could possibly activate TNFAIP8L3 as a compensatory response in the inflammatory pathway. | ||||||
Parthenolide | 20554-84-1 | sc-3523 sc-3523A | 50 mg 250 mg | $81.00 $306.00 | 32 | |
Targets NF-κB signaling, which could influence TNFAIP8L3 expression due to its role in inflammation. | ||||||
Withaferin A | 5119-48-2 | sc-200381 sc-200381A sc-200381B sc-200381C | 1 mg 10 mg 100 mg 1 g | $130.00 $583.00 $4172.00 $20506.00 | 20 | |
Known to inhibit NF-κB activation, which could lead to alterations in TNFAIP8L3 levels as part of immune regulation. | ||||||
BAY 11-7082 | 19542-67-7 | sc-200615B sc-200615 sc-200615A | 5 mg 10 mg 50 mg | $62.00 $85.00 $356.00 | 155 | |
NF-κB inhibitor that could modulate TNFAIP8L3 expression through the inflammatory response pathway. | ||||||
Curcumin | 458-37-7 | sc-200509 sc-200509A sc-200509B sc-200509C sc-200509D sc-200509F sc-200509E | 1 g 5 g 25 g 100 g 250 g 1 kg 2.5 kg | $37.00 $69.00 $109.00 $218.00 $239.00 $879.00 $1968.00 | 47 | |
Modulates NF-κB activity, potentially influencing TNFAIP8L3 expression in the context of inflammation and apoptosis. | ||||||
Resveratrol | 501-36-0 | sc-200808 sc-200808A sc-200808B | 100 mg 500 mg 5 g | $80.00 $220.00 $460.00 | 64 | |
Affects NF-κB pathway, which could alter the expression of TNFAIP8L3 in immune and stress responses. | ||||||
Piperlongumine | 20069-09-4 | sc-364128 | 10 mg | $107.00 | ||
Interacts with NF-κB signaling, which could impact TNFAIP8L3's role in cell survival and apoptosis. | ||||||
Emodin | 518-82-1 | sc-202601 sc-202601A sc-202601B | 50 mg 250 mg 15 g | $105.00 $214.00 $6255.00 | 2 | |
Has been shown to inhibit NF-κB, which could contribute to the modulation of TNFAIP8L3 activity in inflammation and cancer. | ||||||
Quercetin | 117-39-5 | sc-206089 sc-206089A sc-206089E sc-206089C sc-206089D sc-206089B | 100 mg 500 mg 100 g 250 g 1 kg 25 g | $11.00 $17.00 $110.00 $250.00 $936.00 $50.00 | 33 | |
Influences NF-κB signaling, which could lead to an effect on TNFAIP8L3 expression in immune cells. | ||||||
(−)-Epigallocatechin Gallate | 989-51-5 | sc-200802 sc-200802A sc-200802B sc-200802C sc-200802D sc-200802E | 10 mg 50 mg 100 mg 500 mg 1 g 10 g | $43.00 $73.00 $126.00 $243.00 $530.00 $1259.00 | 11 | |
A green tea polyphenol that modulates NF-κB, possibly affecting TNFAIP8L3 expression as part of its anti-inflammatory effects. | ||||||