TEL Activators
The class of 'TEL (ETV6) Activators' includes compounds that may indirectly influence the function or expression of TEL/ETV6, a transcription factor involved in hematopoiesis and leukemogenesis. While direct chemical activators for TEL/ETV6 are not extensively documented, several compounds can modulate its activity by affecting related signaling pathways or cellular processes. All-trans Retinoic Acid (ATRA) is significant for its role in hematopoietic differentiation. Vitamin D derivatives like 1,25-Dihydroxyvitamin D3 are involved in hematopoietic regulation and could impact TEL/ETV6 function. Arsenic Trioxide may affect pathways involving TEL/ETV6.
Tyrosine kinase inhibitors such as Imatinib and Dasatinib, used in chronic myeloid leukemia, could indirectly influence TEL/ETV6 function through their effects on cellular signaling pathways. Forskolin, by elevating cAMP levels, can modulate various cellular processes including those relevant to hematopoiesis and TEL/ETV6 function. Curcumin, with its broad effects on signaling pathways, and Lithium Chloride, affecting the Wnt pathway, could have indirect effects on TEL/ETV6. Nicotinamide, as a modulator of cellular differentiation and survival, also presents capacity for influencing TEL/ETV6. Rapamycin, an mTOR inhibitor, influences cell growth and survival pathways and could indirectly affect TEL/ETV6. JQ1, a BET bromodomain inhibitor, has implications for transcriptional regulation and could impact TEL/ETV6. Lastly, Decitabine, a DNA methyltransferase inhibitor, may influence TEL/ETV6 expression by altering epigenetic regulation.
| Product Name | CAS # | Catalog # | QUANTITY | Price | Citations | RATING |
|---|---|---|---|---|---|---|
Retinoic Acid, all trans | 302-79-4 | sc-200898 sc-200898A sc-200898B sc-200898C | 500 mg 5 g 10 g 100 g | $66.00 $325.00 $587.00 $1018.00 | 28 | |
Known for its role in hematopoietic differentiation and as a treatment for acute promyelocytic leukemia; could indirectly affect TEL/ETV6 function. | ||||||
1α,25-Dihydroxyvitamin D3 | 32222-06-3 | sc-202877B sc-202877A sc-202877C sc-202877D sc-202877 | 50 µg 1 mg 5 mg 10 mg 100 µg | $220.00 $645.00 $1000.00 $1500.00 $440.00 | 32 | |
A form of Vitamin D that regulates hematopoietic processes, potentially influencing TEL/ETV6 expression or function. | ||||||
Arsenic(III) oxide | 1327-53-3 | sc-210837 sc-210837A | 250 g 1 kg | $89.00 $228.00 | ||
Used in the treatment of acute promyelocytic leukemia, which may influence pathways involving TEL/ETV6. | ||||||
Forskolin | 66575-29-9 | sc-3562 sc-3562A sc-3562B sc-3562C sc-3562D | 5 mg 50 mg 1 g 2 g 5 g | $78.00 $153.00 $740.00 $1413.00 $2091.00 | 73 | |
Increases cAMP levels, which can modulate various cellular processes including hematopoiesis, potentially impacting TEL/ETV6 function. | ||||||
Curcumin | 458-37-7 | sc-200509 sc-200509A sc-200509B sc-200509C sc-200509D sc-200509F sc-200509E | 1 g 5 g 25 g 100 g 250 g 1 kg 2.5 kg | $37.00 $69.00 $109.00 $218.00 $239.00 $879.00 $1968.00 | 47 | |
A natural compound known to modulate various signaling pathways, potentially affecting TEL/ETV6. | ||||||
Lithium | 7439-93-2 | sc-252954 | 50 g | $214.00 | ||
Influences the Wnt signaling pathway and other cellular processes, which could indirectly affect TEL/ETV6 function. | ||||||
Nicotinamide | 98-92-0 | sc-208096 sc-208096A sc-208096B sc-208096C | 100 g 250 g 1 kg 5 kg | $44.00 $66.00 $204.00 $831.00 | 6 | |
A form of vitamin B3 that influences cellular differentiation and survival, possibly affecting TEL/ETV6. | ||||||
Rapamycin | 53123-88-9 | sc-3504 sc-3504A sc-3504B | 1 mg 5 mg 25 mg | $63.00 $158.00 $326.00 | 233 | |
An mTOR inhibitor, could have indirect effects on TEL/ETV6 through its role in cell growth and survival pathways. | ||||||
(±)-JQ1 | 1268524-69-1 | sc-472932 sc-472932A | 5 mg 25 mg | $231.00 $863.00 | 1 | |
A BET bromodomain inhibitor, influences transcriptional regulation, potentially affecting TEL/ETV6 function or expression. | ||||||
5-Aza-2′-Deoxycytidine | 2353-33-5 | sc-202424 sc-202424A sc-202424B | 25 mg 100 mg 250 mg | $218.00 $322.00 $426.00 | 7 | |
A DNA methyltransferase inhibitor, studied in the research of myelodysplastic syndromes, could indirectly influence TEL/ETV6 expression by altering epigenetic regulation. | ||||||