TEL Antibody (E-1): sc-166835

TEL Antibody (E-1) is a mouse monoclonal IgG1 kappa light chain antibody that detects TEL protein of mouse, rat, and human origin by western blotting (WB), immunoprecipitation (IP), immunofluorescence (IF), and enzyme-linked immunosorbent assay (ELISA). Anti-TEL antibody (E-1) is available in both non-conjugated and various conjugated forms, including agarose, horseradish peroxidase (HRP), phycoerythrin (PE), fluorescein isothiocyanate (FITC), and multiple Alexa Fluor® conjugates. TEL protein, also known as ETV6, plays a crucial role in hematopoiesis and is involved in the regulation of gene expression during blood cell development. TEL protein′s importance is underscored by involvement in specific chromosomal translocations associated with human leukemias and sarcomas, which can lead to the disruption of normal cellular functions and contribute to oncogenesis. TEL protein′s ability to bind DNA is facilitated by a highly conserved carboxy terminal domain that contains a sequence related to the SV40 large T antigen nuclear localization signal, allowing TEL to interact with specific DNA motifs, including the 5′-GGAA-3′ element. This interaction is vital for the transcriptional regulation of target genes, making TEL protein a significant player in both normal cellular processes and disease states.

Alexa Fluor^® is a trademark of Molecular Probes Inc., OR., USA

LI-COR^® and Odyssey^® are registered trademarks of LI-COR Biosciences

TEL Antibody (E-1) References:

1. TEL is a sequence-specific transcriptional repressor.  |  Lopez, RG., et al. 1999. J Biol Chem. 274: 30132-8. PMID: 10514502
2. TEL-JAK2 transgenic mice develop T-cell leukemia.  |  Carron, C., et al. 2000. Blood. 95: 3891-9. PMID: 10845925
3. TEL-JAK2 constitutively activates the extracellular signal-regulated kinase (ERK), stress-activated protein/Jun kinase (SAPK/JNK), and p38 signaling pathways.  |  Ho, JM., et al. 2002. Blood. 100: 1438-48. PMID: 12149229
4. TEL-AML1 promotes development of specific hematopoietic lineages consistent with preleukemic activity.  |  Morrow, M., et al. 2004. Blood. 103: 3890-6. PMID: 14726384
5. The ets gene family.  |  Seth, A., et al. 1992. Cell Growth Differ. 3: 327-34. PMID: 1633115
6. TEL-AML1 preleukemic activity requires the DNA binding domain of AML1 and the dimerization and corepressor binding domains of TEL.  |  Morrow, M., et al. 2007. Oncogene. 26: 4404-14. PMID: 17237815
7. TEL/AML1-positive patients lacking TEL exon 5 resemble canonical TEL/AML1 cases.  |  Zaliova, M., et al. 2011. Pediatr Blood Cancer. 56: 217-25. PMID: 21157892
8. Identification and preferential expression in thymic and bursal lymphocytes of a c-ets oncogene-encoded Mr 54,000 cytoplasmic protein.  |  Ghysdael, J., et al. 1986. Proc Natl Acad Sci U S A. 83: 1714-8. PMID: 3006066
9. Fusion of PDGF receptor beta to a novel ets-like gene, tel, in chronic myelomonocytic leukemia with t(5;12) chromosomal translocation.  |  Golub, TR., et al. 1994. Cell. 77: 307-16. PMID: 8168137
10. Functional relationships among ETS gene family members.  |  Papas, TS., et al. 1997. Leukemia. 11 Suppl 3: 557-66. PMID: 9209455
11. A novel ETV6-NTRK3 gene fusion in congenital fibrosarcoma.  |  Knezevich, SR., et al. 1998. Nat Genet. 18: 184-7. PMID: 9462753
12. The ETS-domain transcription factor family.  |  Sharrocks, AD., et al. 1997. Int J Biochem Cell Biol. 29: 1371-87. PMID: 9570133

Monoclonal antibodies for mammalian and non-mammalian protein targets represent essentially all targets covered by polyclonal antibodies. Over 8,300 of our antibodies are offered as ImmunoCruz^® conjugates which eliminates the need for a secondary antibody.

Santa Cruz Biotechnology antibodies have over 360,000 research citations. Anti-TEL Antibody (E-1) has 6 citations in a variety of scientific publications.

Primary antibodies like Anti-TEL Antibody (E-1) for mammalian target proteins are recommended for the detection of a range of mammalian species, primarily of mouse, rat and human species. Many mammalian antibodies are also ideal for veterinary research and reactive with ovine, porcine, caprine, feline, canine, bovine and equine protein targets. Santa Cruz Biotechnology primary monoclonal antibodies are suitable for laboratory research applications and are not intended for diagnostic or therapeutic use.

TEL Antibody (E-1) Specifications

Alternate Product Name: TEL

Product Clone Name: E-1

Classification: Primary Antibody

Clonality: Monoclonal Antibody

Antibody Isotype: IgG₁ kappa light chain

Amino Acids: 119-332

Epitope Target: TEL

Epitope Species: human

Product Reactivity/Detection: TEL

Species Reactivity/Detection: mouse, rat, human

Additional Mammalian Reactivity: N/A

Additional Non-Mammalian Reactivity: N/A

Applications: WB, IP, IF, ELISA

Vialing Information: Each vial contains 200 µg IgG₁ kappa light chain in 1.0 ml of PBS with < 0.1% sodium azide and 0.1% gelatin

Research Citations: 6 citations in various scientific publications

Available Conjugates/Forms for TEL Antibody (E-1): AC: Agarose, AF488: Alexa Fluor^® 488, AF546: Alexa Fluor^® 546, AF594: Alexa Fluor^® 594, AF647: Alexa Fluor^® 647, AF680: Alexa Fluor^® 680, AF790: Alexa Fluor^® 790, FITC: Fluoroscein, HRP: Horseradish Peroxidase, PE: Phycoerythrin, X: TransCruz Reagent