Syntaxin 11 Activators
Syntaxin 11 activators largely function by modulating the intracellular signals and processes that influence the activity of Syntaxin 11. Many of these activators are involved in pathways that influence vesicle trafficking and fusion, a key role of Syntaxin 11.
For instance, Thapsigargin, Nifedipine, and BAPTA-AM all modulate calcium levels, which is known to influence Syntaxin 11's role in calcium-dependent exocytosis. Another common mechanism of these activators is through the modulation of kinase activity. Forskolin, PMA, Staurosporine, and the PI3K inhibitors Wortmannin and LY294002, all influence Syntaxin 11 activity through their effects on protein kinases. These kinases can phosphorylate Syntaxin 11 or other proteins involved in the exocytosis process, thereby influencing Syntaxin 11 activity. In addition, activators like 1-Butanol and Calmidazolium Chloride influence Syntaxin 11 activity by modulating lipid signaling and calmodulin activity, respectively, which are other key components of the exocytosis process.
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Items 1 to 10 of 11 total
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| Product Name | CAS # | Catalog # | QUANTITY | Price | Citations | RATING |
|---|---|---|---|---|---|---|
Thapsigargin | 67526-95-8 | sc-24017 sc-24017A | 1 mg 5 mg | $136.00 $446.00 | 114 | |
Thapsigargin is a potent inhibitor of sarco/endoplasmic reticulum Ca2+ ATPases (SERCAs). By inhibiting these ATPases, it causes an increase in intracellular calcium levels, which can activate Syntaxin 11 by facilitating its role in calcium-dependent exocytosis. | ||||||
Forskolin | 66575-29-9 | sc-3562 sc-3562A sc-3562B sc-3562C sc-3562D | 5 mg 50 mg 1 g 2 g 5 g | $78.00 $153.00 $740.00 $1413.00 $2091.00 | 73 | |
Forskolin is a potent activator of adenylyl cyclase, thus increasing levels of cyclic AMP (cAMP). Increased cAMP can stimulate Syntaxin 11 activity as it promotes vesicle fusion in exocytosis. | ||||||
PMA | 16561-29-8 | sc-3576 sc-3576A sc-3576B sc-3576C sc-3576D | 1 mg 5 mg 10 mg 25 mg 100 mg | $41.00 $132.00 $214.00 $500.00 $948.00 | 119 | |
PMA is a potent activator of Protein Kinase C (PKC). PKC has been implicated in regulating Syntaxin 11, especially in the process of vesicular trafficking and exocytosis. | ||||||
Nifedipine | 21829-25-4 | sc-3589 sc-3589A | 1 g 5 g | $59.00 $173.00 | 15 | |
Nifedipine is a calcium channel blocker. By altering calcium fluxes, it can indirectly affect Syntaxin 11 activity related to calcium-dependent exocytosis. | ||||||
Calmidazolium chloride | 57265-65-3 | sc-201494 sc-201494A | 10 mg 50 mg | $156.00 $612.00 | 27 | |
Calmidazolium Chloride is a calmodulin antagonist. Since calmodulin has a role in facilitating exocytosis, antagonizing it can indirectly influence Syntaxin 11 activity. | ||||||
8-Bromoadenosine 3′,5′-cyclic monophosphate | 23583-48-4 | sc-217493B sc-217493 sc-217493A sc-217493C sc-217493D | 25 mg 50 mg 100 mg 250 mg 500 mg | $108.00 $169.00 $295.00 $561.00 $835.00 | 2 | |
8-Bromoadenosine 3',5'-cyclic monophosphate is a cell-permeable cAMP analog. It can increase Syntaxin 11 activity by promoting vesicle fusion in exocytosis, similar to Forskolin. | ||||||
Wortmannin | 19545-26-7 | sc-3505 sc-3505A sc-3505B | 1 mg 5 mg 20 mg | $67.00 $223.00 $425.00 | 97 | |
Wortmannin is a potent inhibitor of phosphoinositide 3-kinases (PI3K). As PI3K is involved in vesicular trafficking, its inhibition can indirectly influence Syntaxin 11 activity. | ||||||
LY 294002 | 154447-36-6 | sc-201426 sc-201426A | 5 mg 25 mg | $123.00 $400.00 | 148 | |
LY294002 is another potent inhibitor of PI3K. Like Wortmannin, it can indirectly influence Syntaxin 11 activity by affecting vesicular trafficking. | ||||||
Okadaic Acid | 78111-17-8 | sc-3513 sc-3513A sc-3513B | 25 µg 100 µg 1 mg | $291.00 $530.00 $1800.00 | 78 | |
Okadaic Acid is a potent inhibitor of protein phosphatases 1 and 2A. By influencing protein phosphorylation status, it can indirectly affect Syntaxin 11 activity. | ||||||
BAPTA/AM | 126150-97-8 | sc-202488 sc-202488A | 25 mg 100 mg | $138.00 $458.00 | 61 | |
BAPTA/AM is a cell-permeable Ca2+ chelator. By altering intracellular calcium levels, it can indirectly influence Syntaxin 11 activity related to calcium-dependent exocytosis. | ||||||