Calmidazolium chloride CAS: 57265-65-3
MF: C31H23Cl6N2O•Cl
MW: 687.69
A CaM and calcium channel protein inhbitor.

Calmidazolium chloride (CAS 57265-65-3)

Calmidazolium chloride | CAS 57265-65-3 is rated 5.0 out of 5 by 1.
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Alternate Names: 1-[Bis(4-chlorophenyl)methyl]-3-[2,4-dichloro-β-(2,4-dichlorobenzyloxy)phenethyl]imidazolium chloride;R 24571
Application: Calmidazolium chloride is a CaM and calcium channel protein inhbitor
CAS Number: 57265-65-3
Purity: ≥98%
Molecular Weight: 687.69
Molecular Formula: C31H23Cl6N2O•Cl
For Research Use Only. Not Intended for Diagnostic or Therapeutic Use.
* Refer to Certificate of Analysis for lot specific data (including water content).

Calmidazolium chloride is a small molecule CaM antagonist and calcium channel protein inhibitor. Calmidazolium chloride demonstrates noncompetitive inhibition of platelet and sarcoplasmic reticulum Ca2+-ATPase activity and shows inhibition of Ca2+ transport activity in platelet microsomes. In HeLa cells, calmidazolium chloride stimulates a mechanism of cellular Ca2+ influx distinct from store-operated Ca2+ entry and unaccompanied by Ca2+ store depletion, mobilizing stores and evoking a Ca2+ signal through activation of phospholipase C. Calmidazolium chloride is described to inhibit constitutive nitric oxide synthase (NOS) activity without affecting inducible NOS in rat aorta. The dependence upon calmodulin of neuronal NOS (nNOS) in neuroblastoma N1E-115 cells was probed with calmidazolium chloride, where it was demonstrated to increase cGMP levels indirectly indicating an increase in NO output by nNOS. Calmidazolium chloride is also described to inhibit the activity of calmodulin N-methyltransferase.


References

1. Fischer, T.H., et al. 1987. Biochemistry. 26: 8024-8030. PMID: 2962642
2. Schini, V.B., et al. 1992. J. Pharmacol. Exp. Ther. 261: 553-559. PMID: 1374468
3. Hu, J. and el-Fakahany, E.E. 1993. Neuroreport. 4: 198-200. PMID: 8384025
4. Harper, J.L., et al. 2000. Biochem. Pharmacol. 60: 317-324. PMID: 10856426
5. Peppiatt, C.M., et al. 2004. Biochem. J. 381: 929-939. PMID: 15130089

Appearance :
Powder
Physical State :
Solid
Solubility :
Soluble in 100% ethanol (>100 mg/ml), DMSO (>100 mg/ml), methanol, chloroform, and propylene glycol. Insoluble in water.
Storage :
Store at -20° C
IC50 :
Ca2+/calmodulin-induced activation of myosin light chain kinase: IC50 = 1 µM; Calmodulin-dependent phosphodiesterase: IC50 = 0.15 µM; Ca2+-transporting ATPase : IC50 = 0.35 µM; Ubiquitin-conjugating enzyme E2 N: IC50 = 5.60 µM (human); HEK293 (Embryonic kidney fibroblasts): IC50 = 2.01 µM (human); Bcl-2-related protein A1: IC50 = 6.23 µM (Mus musculus); Apoptotic protease-activating factor 1: IC50 = 12.7 µM (human); Mycobacterium smegmatis: IC50 = 7.02 µM; Insulin-degrading enzyme: EC5050 = >2.03 µM (human)
Ki Data :
calmodulin N-methyltransferase: Ki= 65 nM
For Research Use Only. Not Intended for Diagnostic or Therapeutic Use.
WGK Germany :
3
PubChem CID :
644274
MDL Number :
MFCD00077679
Beilstein Registry :
6470244
SMILES :
C1=CC(=CC=C1C(C2=CC=C(C=C2)Cl)N3C=C[N+](=C3)CC(C4=C(C=C(C=C4)Cl)Cl)OCC5=C(C=C(C=C5)Cl)Cl)Cl.[Cl-]

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Certificate of Analysis

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Calmidazolium chloride (CAS 57265-65-3)  Product Citations

See how others have used Calmidazolium chloride (CAS 57265-65-3). Click on the entry to view the PubMed entry .

Citations 1 to 10 of 23 total

PMID: # 28839011  Nogueira, RC. et al. 2017. J. Exp. Biol.

PMID: # 27045615  Smith, KP. et al. 2016. Assay Drug Dev Technol. 14: 194-206.

PMID: # 24224022  Chen, R. et al. 2013. PloS one. 8: e79930.

PMID: # 23108402  Can, G. et al. 2013. Oncogene. 32: 4529-38.

PMID: # 18508773  Kalman, K. et al. 2008. J. Biol. Chem. 283: 21278-21283.

PMID: # 16300634  Nachmany, A. et al. 2006. J. Neurochem. 96: 247-253.

PMID: # 14752100  Turner, JH. et al. 2004. J. Biol. Chem. 279: 17027-17037.

PMID: # 11329382  Mills, IG. et al. 2001. J. Cell. Sci. 114: 1959-1965.

PMID: # 11294857  Alvarez-Tejado, M. et al. 2001. J. Biol. Chem. 276: 22368-22374.

PMID: # 10067851  Tyson, DR. et al. 1999. Endocrinology. 140: 1255-1261.

Citations 1 to 10 of 23 total
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Rated 5 out of 5 by from Kalman et al Kalman et al. (PubMed ID 18508773) used Calmidazolium chloride, a Calmodulin inhibitor, while studying the effects of phosphorylation on calcium-regulated response and permeability of aquaporins present in Xenopus oocytes. -SCBT Publication Review
Date published: 2015-06-25
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