Molecular structure of Calmidazolium chloride, CAS Number: 57265-65-3
Calmidazolium chloride (CAS 57265-65-3)
See product citations (27)
Alternate Names:
1-[Bis(4-chlorophenyl)methyl]-3-[2,4-dichloro-β-(2,4-dichlorobenzyloxy)phenethyl]imidazolium chloride;R 24571
Application:
Calmidazolium chloride is a CaM and calcium channel protein inhbitor
CAS Number:
57265-65-3
Purity:
≥98%
Molecular Weight:
687.69
Molecular Formula:
C31H23Cl6N2O•Cl
For Research Use Only. Not Intended for Diagnostic or Therapeutic Use.
* Refer to Certificate of Analysis for lot specific data.
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SDS & Certificate of Analysis
Calmidazolium chloride is a small molecule CaM antagonist and calcium channel protein inhibitor. Calmidazolium chloride demonstrates noncompetitive inhibition of platelet and sarcoplasmic reticulum Ca2+-ATPase activity and shows inhibition of Ca2+ transport activity in platelet microsomes. In HeLa cells, calmidazolium chloride stimulates a mechanism of cellular Ca2+ influx distinct from store-operated Ca2+ entry and unaccompanied by Ca2+ store depletion, mobilizing stores and evoking a Ca2+ signal through activation of phospholipase C. Calmidazolium chloride is described to inhibit constitutive nitric oxide synthase (NOS) activity without affecting inducible NOS in rat aorta. The dependence upon calmodulin of neuronal NOS (nNOS) in neuroblastoma N1E-115 cells was probed with calmidazolium chloride, where it was demonstrated to increase cGMP levels indirectly indicating an increase in NO output by nNOS. Calmidazolium chloride is also described to inhibit the activity of calmodulin N-methyltransferase.
Calmidazolium chloride (CAS 57265-65-3) References
- Effect of calmidazolium analogs on calcium influx in HL-60 cells. | Harper, JL. and Daly, JW. 2000. Biochem Pharmacol. 60: 317-24. PMID: 10856426
- Inhibitors of calmodulin impair the constitutive but not the inducible nitric oxide synthase activity in the rat aorta. | Schini, VB. and Vanhoutte, PM. 1992. J Pharmacol Exp Ther. 261: 553-9. PMID: 1374468
- Calmidazolium and arachidonate activate a calcium entry pathway that is distinct from store-operated calcium influx in HeLa cells. | Peppiatt, CM., et al. 2004. Biochem J. 381: 929-39. PMID: 15130089
- Effect of calmidazolium on [Ca2+]i and viability in human hepatoma cells. | Liao, WC., et al. 2009. Arch Toxicol. 83: 61-8. PMID: 18629476
- Cardiotoxicity of calmidazolium chloride is attributed to calcium aggravation, oxidative and nitrosative stress, and apoptosis. | Kumar, S., et al. 2009. Free Radic Biol Med. 47: 699-709. PMID: 19497364
- Calmidazolium evokes high calcium fluctuations in Plasmodium falciparum. | Budu, A., et al. 2016. Cell Signal. 28: 125-135. PMID: 26689736
- Calmidazolium chloride inhibits growth of murine embryonal carcinoma cells, a model of cancer stem-like cells. | Lee, J., et al. 2016. Toxicol In Vitro. 35: 86-92. PMID: 27247146
- An investigation of functional similarities between the sarcoplasmic reticulum and platelet calcium-dependent adenosinetriphosphatases with the inhibitors quercetin and calmidazolium. | Fischer, TH., et al. 1987. Biochemistry. 26: 8024-30. PMID: 2962642
- Calmidazolium Chloride and Its Complex with Serum Albumin Prevent Huntingtin Exon1 Aggregation. | Singh, V., et al. 2018. Mol Pharm. 15: 3356-3368. PMID: 29979597
- Calmidazolium induces a decrease in nicotine-induced currents and intracellular calcium levels after pulse application of nicotine onto insect neurosecretory cells. | Houchat, JN., et al. 2022. J Insect Physiol. 139: 104385. PMID: 35315336
- Dynamics and structural changes of calmodulin upon interaction with the antagonist calmidazolium. | Léger, C., et al. 2022. BMC Biol. 20: 176. PMID: 35945584
- The calmodulin antagonist calmidazolium stimulates release of nitric oxide in neuroblastoma N1E-115 cells. | Hu, J. and el-Fakahany, EE. 1993. Neuroreport. 4: 198-200. PMID: 8384025
- Injections of calmidazolium chloride into the ipsilateral medial vestibular nucleus or fourth ventricle reduce spontaneous ocular nystagmus following unilateral labyrinthectomy in guinea pigs. | Sansom, AJ., et al. 1993. Exp Brain Res. 93: 271-8. PMID: 8491266
Inhibitor of:
ACOT11, APBA2BP, ATP8A1, ATPase, C2CD4D, C8β, C8orf31, CAB39L, CaBP1, CaBP5, CABYR, Calcium Channel Protein, CALML3, CALML4, CALML5, CaM, CaM II, CaM III, CaMKIγ, CaMKIIδ, CaMKIIγ, CaMKIIN1, CaMKIIN2, CARD 11, CASKIN1, CHERP, CIB2, EDF1, hippocalcin, INPP5J, IP6K1, IP6K2, IP6K3, IQCC, KIAA1543, Kua, LAT, LIN-2, LOC642574, NOS, Olfr373, Olfr446, Olfr447, Olfr47, Olfr610, Olfr651, Olfr652, Olfr66, Olfr661, Olfr663, Olfr993, Olfr994, Olfr995, Olfr996, Olfr998, Otoconin 90, PCDHA6, PCDHA8, PCNXL3, phospholamban, PMCA1, PMCA3, PRAMEF8, PRRG1, PRRG2, Recoverin, S-100, SPSY, Troponin T-SS, and XKR5.Activator of:
μ-protocadherin, 1700106N22Rik, ATP13A1, cadherin-19, Calpactin, Calpain 14, Calpain 15_Solh, CaMKIIα, CaMKKα, CAPSL, copine 2, copine 8, EYA, HIPK4_Hipk4, HYDIN, IPPK, Junctophilin-3, MTMR7, Neurogranin, PCDH7, plexin-D1, PPEF-1, Rim1, S-100A10, SCFD2, Syntaxin 11, TMEM16J, Tropomyosin β, TTC38, Tuba, and ULBP3.Ordering Information
| Product Name | Catalog # | UNIT | Price | Qty | FAVORITES | |
Calmidazolium chloride, 10 mg | sc-201494 | 10 mg | $156.00 | |||
Calmidazolium chloride, 50 mg | sc-201494A | 50 mg | $612.00 |