Syntaxin 11 Antibody (A-4): sc-377121
- Syntaxin 11 Antibody (A-4) is a mouse monoclonal IgG2a κ Syntaxin 11 antibody, cited in 2 publications, provided at 200 µg/ml
- raised against amino acids 147-266 mapping near the C-terminus of Syntaxin 11 of human origin
- Syntaxin 11 Antibody (A-4) is recommended for detection of Syntaxin 11 of human origin by WB, IP, IF and ELISA
- Anti-Syntaxin 11 Antibody (A-4) is available conjugated to agarose for IP; HRP for WB, IHC(P) and ELISA; and to either phycoerythrin or FITC for IF, IHC(P) and FCM
- also available conjugated to Alexa Fluor® 488, Alexa Fluor® 546, Alexa Fluor® 594 or Alexa Fluor® 647 for WB (RGB), IF, IHC(P) and FCM, and for use with RGB fluorescent imaging systems, such as iBright™ FL1000, FluorChem™, Typhoon, Azure and other comparable systems
- also available conjugated to Alexa Fluor® 680 or Alexa Fluor® 790 for WB (NIR), IF and FCM; for use with Near-Infrared (NIR) detection systems, such as LI-COR®Odyssey®, iBright™ FL1000, FluorChem™, Typhoon, Azure and other comparable systems
- m-IgG Fc BP-HRP, m-IgG2a BP-HRP and m-IgGκ BP-HRP are the preferred secondary detection reagents for Syntaxin 11 Antibody (A-4) for WB applications. These reagents are now offered in bundles with Syntaxin 11 Antibody (A-4) (see ordering information below).
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Syntaxin 11 Antibody (A-4) is a mouse monoclonal IgG2a kappa light chain antibody that detects Syntaxin 11 of human origin by western blotting (WB), immunoprecipitation (IP), immunofluorescence (IF), and enzyme-linked immunosorbent assay (ELISA). anti-Syntaxin 11 antibody (A-4) is available in both non-conjugated and various conjugated forms, including agarose, horseradish peroxidase (HRP), phycoerythrin (PE), fluorescein isothiocyanate (FITC), and multiple Alexa Fluor® conjugates. Syntaxin 11, also known as STX11, FHL4, HLH4, or HPLH4, is a 287 amino acid protein that plays a crucial role in intracellular membrane fusion processes, particularly in the transport of proteins between the trans-Golgi network and late endosomes. Syntaxin 11 contains a t-SNARE coiled-coil homology domain, which is essential for mediating vesicle fusion. Proper localization of Syntaxin 11 to the membrane of the trans-Golgi network is vital for maintaining cellular homeostasis and ensuring efficient protein trafficking. Disruptions in Syntaxin 11 function can lead to severe consequences, such as familial hemophagocytic lymphohistiocytosis type 4 (FHL4), a genetic disorder characterized by a hyper-inflammatory response, which can result in symptoms like fever, hepatosplenomegaly, and neurological deficits. Syntaxin 11′s ability to interact with other proteins, such as SNAP-23 and VAMP, further underscores its importance in the regulation of vesicular transport and highlights the potential implications of its dysfunction in various diseases.
Alexa Fluor® is a trademark of Molecular Probes Inc., OR., USA
LI-COR® and Odyssey® are registered trademarks of LI-COR Biosciences
Syntaxin 11 Antibody (A-4) References:
- Syntaxin 11 is associated with SNAP-23 on late endosomes and the trans-Golgi network. | Valdez, AC., et al. 1999. J Cell Sci. 112 (Pt 6): 845-54. PMID: 10036234
- Linkage of familial hemophagocytic lymphohistiocytosis (FHL) type-4 to chromosome 6q24 and identification of mutations in syntaxin 11. | zur Stadt, U., et al. 2005. Hum Mol Genet. 14: 827-34. PMID: 15703195
- Mutations of syntaxin 11 and SNAP23 genes as causes of familial hemophagocytic lymphohistiocytosis were not found in Japanese people. | Yamamoto, K., et al. 2005. J Hum Genet. 50: 600-603. PMID: 16180048
- Mutation spectrum in children with primary hemophagocytic lymphohistiocytosis: molecular and functional analyses of PRF1, UNC13D, STX11, and RAB27A. | Zur Stadt, U., et al. 2006. Hum Mutat. 27: 62-8. PMID: 16278825
- Defective cytotoxic lymphocyte degranulation in syntaxin-11 deficient familial hemophagocytic lymphohistiocytosis 4 (FHL4) patients. | Bryceson, YT., et al. 2007. Blood. 110: 1906-15. PMID: 17525286
- Cutting edge: syntaxin 11 regulates lymphocyte-mediated secretion and cytotoxicity. | Arneson, LN., et al. 2007. J Immunol. 179: 3397-401. PMID: 17785771
- Characterization of PRF1, STX11 and UNC13D genotype-phenotype correlations in familial hemophagocytic lymphohistiocytosis. | Horne, A., et al. 2008. Br J Haematol. 143: 75-83. PMID: 18710388
- Syntaxin 11: a member of the syntaxin family without a carboxyl terminal transmembrane domain. | Tang, BL., et al. 1998. Biochem Biophys Res Commun. 245: 627-32. PMID: 9571206
Ordering Information
| Product Name | Catalog # | UNIT | Price | Qty | FAVORITES | |
Syntaxin 11 Antibody (A-4) | sc-377121 | 200 µg/ml | $322.00 | |||
Syntaxin 11 Antibody (A-4): m-IgG Fc BP-HRP Bundle | sc-529980 | 200 µg Ab; 10 µg BP | $361.00 | |||
Syntaxin 11 Antibody (A-4): m-IgGκ BP-HRP Bundle | sc-523198 | 200 µg Ab, 40 µg BP | $361.00 | |||
Syntaxin 11 Antibody (A-4): m-IgG2a BP-HRP Bundle | sc-551257 | 200 µg Ab; 10 µg BP | $361.00 | |||
Syntaxin 11 Antibody (A-4) AC | sc-377121 AC | 500 µg/ml, 25% agarose | $424.00 | |||
Syntaxin 11 Antibody (A-4) HRP | sc-377121 HRP | 200 µg/ml | $322.00 | |||
Syntaxin 11 Antibody (A-4) FITC | sc-377121 FITC | 200 µg/ml | $336.00 | |||
Syntaxin 11 Antibody (A-4) PE | sc-377121 PE | 200 µg/ml | $349.00 | |||
Syntaxin 11 Antibody (A-4) Alexa Fluor® 488 | sc-377121 AF488 | 200 µg/ml | $364.00 | |||
Syntaxin 11 Antibody (A-4) Alexa Fluor® 546 | sc-377121 AF546 | 200 µg/ml | $364.00 | |||
Syntaxin 11 Antibody (A-4) Alexa Fluor® 594 | sc-377121 AF594 | 200 µg/ml | $364.00 | |||
Syntaxin 11 Antibody (A-4) Alexa Fluor® 647 | sc-377121 AF647 | 200 µg/ml | $364.00 | |||
Syntaxin 11 Antibody (A-4) Alexa Fluor® 680 | sc-377121 AF680 | 200 µg/ml | $364.00 | |||
Syntaxin 11 Antibody (A-4) Alexa Fluor® 790 | sc-377121 AF790 | 200 µg/ml | $364.00 |